High-drug-loading degradable alginate sulfate vascular embolization microspheres and preparation method and application thereof

Abstract

The invention discloses a preparation method of high-drug-loading degradable alginate sulfate vascular embolization microspheres. The preparation method comprises the following steps of: S01, preparing an aqueous phase; S02, preparing an oil phase; S03, preparing alginate sulfate microspheres; and S04, preparing drug-loaded alginate sulfate embolization microspheres. The invention also discloses the high-drug-loading degradable alginate sulfate vascular embolization microspheres obtained by the preparation method of the high-drug-loading degradable alginate sulfate vascular embolization microspheres and application of the high-drug-loading degradable alginate sulfate vascular embolization microspheres in preparation of an embolization agent for transcatheter arterial chemoembolization treatment. The alginate sulfate vascular embolization microspheres disclosed by the invention have good biocompatibility and are biodegradable, and the degradation product is safe and non-toxic. The preparation method has the advantages of simplicity and convenience in operation, high repeatability, mild conditions and the like, the prepared microspheres are uniform and controllable in particle size, and the vascular embolization microspheres prepared by the invention have good application prospects in the field of tumor interventional therapy.

Description

technical field [0001] The invention relates to a highly drug-loaded degradable alginate sulfate vascular embolization microsphere, a preparation method and application thereof, and belongs to the technical field of biomedical materials. Background technique [0002] Transcatheter Arterial Chemoembolization (TACE) refers to the controlled injection of embolic materials into the supply vessels of diseased organs through intra-arterial catheters, causing occlusion and interruption of blood supply, in order to control bleeding and treat tumors. and vascular lesions and techniques for eliminating diseased organs. TACE is mostly used clinically in the treatment of malignant tumors that are difficult to interfere with conventional therapies (such as surgery and chemotherapy). Taking liver cancer as an example, its clinical treatment methods are very limited, as follows: ①Surgery is the first choice for liver cancer treatment, but due to the complex physiological structure of the ...

AI Technical Summary

Problems solved by technology

At present, the drug-loaded microsphere products on the market are all non-degradable microspheres, and there are two core problems: ①Due to the limitation of raw materials and process, the content of drug-loaded groups is very limited, and it is difficult to meet the actual needs of more complex interventional embolization therapy ;②The drug release mechanism is the elution effect of the surrounding solution (such as blood, interstitial fluid). Because the raw materials are not degradable and cannot be released, the release function of drug-loaded microspheres is jointly restricted. The development of new drug-loaded embolic microspheres with larger drug-loading space and degradable drug release is an inevitable trend in the development of TACE technology in the era of precision medicine.

However, a comprehensive analysis of existing degradable interventional biomedical materials found that degradable materials generally lack drug-loading groups to achieve drug-loading functions, or it is difficult to balance embolization / degradation functions, or there are safety hazards, such as: gelatin sponge (degradation speed Too fast embolization period is short, no drug-loaded groups), sodium alginate (no drug-loaded groups), polylactic acid (degradation products are highly irritating to tissues), chitosan (hemolysis risk), etc.

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