Preparation equipment for preparing diclofenac sodium sustained-release composition through melting and preparation process of diclofenac sodium sustained-release composition

Abstract

The invention relates to the technical field of preparation of diclofenac sodium sustained-release compositions and particularly relates to preparation equipment for preparing a diclofenac sodium sustained-release composition through melting and a preparation process of the diclofenac sodium sustained-release composition. The preparation equipment comprises a melter body, wherein a crushing mechanism is mounted on the melter body, a conveying mechanism is mounted in the crushing mechanism, a cooling mechanism is arranged in the crushing mechanism, two locking mechanisms are mounted in the crushing mechanism, a protection mechanism is connected into the crushing mechanism, and a discharging mechanism is connected to the melter body. The melting efficiency of a wax material is increased through the action of the crushing mechanism, material conveying is facilitated through the conveying mechanism, blockage is prevented, heat dissipation and cooling of the crushing mechanism are facilitated under the action of the cooling mechanism, the working life is prolonged, the crushing mechanism is stably mounted under the action of the locking mechanisms, follow-up maintenance and cleaning are facilitated, materials can be conveniently, rapidly and smoothly discharged through the discharging mechanism, and the blockage is prevented.

Description

technical field [0001] The invention relates to a preparation equipment for a diclofenac sodium sustained-release composition, in particular to a preparation equipment and a preparation process for melting a diclofenac sodium sustained-release composition, and belongs to the technical field of diclofenac sodium sustained-release composition preparation. Background technique [0002] Diclofenac sodium is a second-generation powerful non-steroidal anti-inflammatory drug, which has obvious analgesic, anti-inflammatory and antipyretic effects. Diclofenac sodium inhibits the synthesis of arachidonic acid by inhibiting cyclooxygenase in the body, reducing the synthesis of prostaglandins , so as to play anti-rheumatic, anti-inflammatory, analgesic and antipyretic effects. [0003] Patent No.: 201810835414.4 A diclofenac sodium sustained-release composition and its preparation method can efficiently prepare diclofenac sodium sustained-release compositions. However, in the preparatio...

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Problems solved by technology

[0003] Patent No.: 201810835414.4 A diclofenac sodium sustained-release composition and its preparation method can efficiently prepare diclofenac sodium sustained-release compositions. However, in the preparation of diclofenac sodium sustained-release compositions, waxy materials are directly put into a melting furnace. Melting, due to the large volume of waxy materials, the speed is slow when melting large pieces, which reduces the overall preparation efficiency. At the same time, waxy materials have a certain viscosity, and the resistance of the equipment is large when it is broken, which will generate a lot of heat. Sufficient heat dissipation can ensure the service life of the equipment. At the same time, the flow rate is slow when the material is conveyed, which may easily cause internal pipeline blockage, and it is inconvenient to dredge after the discharge port is blocked, which will affect the subsequent conveying work.

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