Essence emulsion composition containing lipid nanoparticles with wrinkle-removing and tightening effects and preparation method thereof
A lipid nanoparticle and composition technology, applied in the field of daily chemicals, can solve problems such as unsatisfactory effects, and achieve the effects of improving skin residue and transdermal absorption efficiency, slowing skin aging, and strengthening dermal collagen.
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[0086] An essence milk composition containing lipid nanoparticles with anti-wrinkle and firming effect is made into anti-wrinkle and firming essence milk, and the proportion and content of raw material components are shown in Table 1 below.
[0087] The raw material component distribution ratio (unit: mass %) of table 1 embodiment 1-3
[0088]
[0089] The preparation process of the anti-wrinkle and firming essence milk composition of the above-mentioned embodiment 1 comprises the following steps:
[0090] 1) Preparation of lipid nanoparticle a with anti-wrinkle and firming effect:
[0091] 500mg glyceryl tristearate was fully dissolved in 20mL of dichloromethane containing 1% Span 80 to obtain an oil phase; 36mg acetyl tetrapeptide-5, 45mg palmitoyl tripeptide-1 and palmitoyl tetrapeptide 7. Fully dissolve 45 mg of Ascophyllum nodosum extract in 5 mL of water to obtain water phase 1; after adding water phase 1 to the oil phase, use a cell pulverizer to ultrasonically emul...
Embodiment 1
[0109] Test sample: embodiment 1;
[0110] Test method: Use a third-party testing agency to test the safety. Select an area not exceeding 50mm 2 , with a suitable patch device with a depth of about 1mm, add about 0.02-0.025ml (g) of the test substance to the patch test device in a closed patch test method. Stick the spot tester on the curved side of the forearm of the subject, remove the test substance after 24 hours, observe the skin reaction at 0.5h, 24h, and 48h after removal, and record the results according to the skin reaction classification standard in "Cosmetic Safety Technical Regulations 2015" .
[0111] Table 2 Patch test results
[0112]
[0113]
[0114] Remarks: Skin reaction grading standard;
[0115] Level 0: Negative reaction;
[0116] Grade 1: Suspicious reaction; only faint erythema;
[0117] Grade 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, papules may be present;
[0118] Grade 3: strong positive reaction (her...
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