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Pharmaceutical composition for rapid healing of osteoporosis fracture

A technology for osteoporosis and composition, applied in the field of western medicine, can solve the problems of insufficient bone fusion and slow osteogenesis

Active Publication Date: 2021-11-30
AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In view of the fact that when osteoporotic fractures are treated with simple surgical fixation and implants, there are often clinical problems such as insufficient bone fusion and slow osteogenesis, the purpose of the present invention is to provide a rapid A medicinal composition for healing to solve the above technical problems

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  • Pharmaceutical composition for rapid healing of osteoporosis fracture
  • Pharmaceutical composition for rapid healing of osteoporosis fracture

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Embodiment Construction

[0017] The present invention will be further described in detail according to specific test examples below, and the advantages and characteristics of the present invention will become clearer along with the description. Those skilled in the art should understand that the details and forms of the technical solution can be modified or replaced without departing from the spirit of the present invention, but these modifications or replacements all fall within the protection scope of the present invention.

[0018] 48 SD male rats, weighing 260-300g, were divided into blank control group, model control group, trimebutine group, alendronate sodium group, trimebutine-alendronate sodium group according to random number table method Low-dose group and trimebutine-alendronate high-dose group, 8 rats in each group.

[0019] Except for the blank control group, rats in other groups were intragastrically administered retinoic acid 70mg / kg, once a day, and rats were osteoporosis after 2 week...

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Abstract

The invention belongs to the technical field of western medicines, and discloses a pharmaceutical composition for rapid healing of osteoporosis fracture. The pharmaceutical composition is an oral preparation, and the oral preparation is prepared from trimebutine maleate, bisphosphonates and pharmaceutically acceptable auxiliary materials. According to the pharmaceutical composition, the biological activity of bisphosphonates for promoting bone formation is improved in vivo through trimebutine maleate, meanwhile, the functional activity of osteoclast is reduced, and the bone absorption activity is inhibited, so that the bone density is synergistically improved, and rapid healing of osteoporosis fracture is promoted.

Description

technical field [0001] The invention belongs to the technical field of western medicine, relates to a medicine for bone wound healing, in particular to a medicine composition for rapid healing of osteoporotic fractures. Background technique [0002] Osteoporosis is a systemic bone disease in which bone density and bone quality decrease and bone microstructure is destroyed due to various reasons, resulting in increased bone fragility and prone to fracture [CHEUNG WH, MICLAU T, CHOW SKH, et al. Fracture healing in osteoporotic bone. Injury. 2016; 47(Suppl 2): ​​S21-S26.]. According to physiological and anatomical standards, bone tissue is composed of cells, fibers, and matrix. It is a connective tissue with high density and high hardness. Its elastic properties allow bone tissue to deform to a certain extent under load. The biomechanical properties of bone tissue depend on bone density and trabecular distribution and are also affected by osteoporosis. Bone tissue can be divi...

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Application Information

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IPC IPC(8): A61K31/24A61K31/663A61K31/675A61K9/20A61P19/08A61P19/10
CPCA61K31/24A61K31/675A61K31/663A61K9/0053A61K9/2059A61K9/2018A61K9/2054A61K9/2013A61K9/2009A61P19/08A61P19/10A61K2300/00
Inventor 孙鹏韩亮邢春叶
Owner AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
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