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HNC (Head and Neck Cancer) prognosis biomarker based on lymph node microbial flora and application of HNC prognosis biomarker

A biomarker, head and neck cancer technology, applied in the field of disease prognosis and molecular biology, can solve the problem of lack of in-depth research on head and neck cancer-related bacteria, and achieve a good predictive effect

Pending Publication Date: 2021-11-23
SHANDONG UNIV +1
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Problems solved by technology

At present, the research on the mechanism of the occurrence and development of head and neck cancer mainly focuses on individual genetics, but there is no in-depth study on the related flora of head and neck cancer.

Method used

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  • HNC (Head and Neck Cancer) prognosis biomarker based on lymph node microbial flora and application of HNC prognosis biomarker
  • HNC (Head and Neck Cancer) prognosis biomarker based on lymph node microbial flora and application of HNC prognosis biomarker
  • HNC (Head and Neck Cancer) prognosis biomarker based on lymph node microbial flora and application of HNC prognosis biomarker

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Experimental program
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Embodiment

[0079] experimental method

[0080] 1. Clinical cohort

[0081] Patients with head and neck cancer who were admitted to Qilu Hospital of Shandong University from January 2006 to March 2015 were included in this study.

[0082] 1.1 Inclusion conditions:

[0083] Aged 20-76 years old, gender is not limited, tumor resection and pathologically confirmed as the primary case of head and neck cancer, the tumor site includes the oral cavity (tongue, floor of the mouth, gums, buccal mucosa, hard palate, retromolar area) and oral cavity Pharynx (soft palate, base of tongue and tonsils).

[0084] 1.2 Exclusions:

[0085] Those who have a history of head and neck cancer and other tumors in the past, and have undergone surgery, radiotherapy and chemotherapy.

[0086] 1.3 Experimental scheme:

[0087] All subjects were followed up until May 2019 or died.

[0088] 2. Sequencing

[0089] DNA was extracted from paraffin-embedded lymph node tissue, and 16s rRNA was amplified for the V4 v...

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Abstract

The invention provides an HNC (Head and Neck Cancer) prognosis biomarker based on a lymph node microbial flora and application of the HNC prognosis biomarker, and belongs to the technical field of disease prognosis and molecular biology. According to the invention, the 16S ribosomal RNA gene of the lymph node microbial flora of an HNC patient is subjected to high-throughput sequencing, so that it is proved that different species exist in flora species of metastatic lymph nodes and non-metastatic lymph nodes in the HNC patient; furthermore, through a microbial flora symbiotic relationship network, it is found that the flora interrelation between the species of the metastatic lymph node and the species of the non-metastatic lymph node of the HNC patient is also different at the genus level; the result discovers the characteristics of the microbiome of the metastatic lymph node and the non-metastatic lymph node of the HNC patient for the first time; and meanwhile, it is known by analysis that the flora difference characteristics (diversity index values and relative abundance of different species) have a good prediction effect on the lifetime (total lifetime and three-year lifetime) of the HNC patient, so that the invention has a good practical application value.

Description

technical field [0001] The invention belongs to the technical field of disease prognosis and molecular biology, and specifically relates to a head and neck cancer prognosis biomarker based on lymph node microbial flora and its application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Head and Neck Cancer (HNC) refers to malignant tumors that occur in the head and neck, including the oral cavity, oropharynx, nasopharynx, and larynx. There are about 650,000 new cases of head and neck cancer each year worldwide. One of the more common malignant tumors has seriously threatened human life and health. The scientific community is still not completely clear about the cause of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/06G16H50/30
CPCC12Q1/06G16H50/30G01N2800/7028G01N2800/52
Inventor 窦宇徐欣曲迅王克涛刘少华董召刚
Owner SHANDONG UNIV
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