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Tissue engineering hydrogel scaffold for promoting cell migration, preparation method of tissue engineering hydrogel scaffold, 3D printing slurry and preparation method of 3D printing slurry

A technology of tissue engineering and cell migration, applied in tissue regeneration, additive processing, medical science, etc., can solve the problems of lack of energy source, difficulty in tissue regeneration, and influence on physiological activity of cells inside the tissue, and improve poor mechanical properties , good mechanical properties, and high biological activity of the material

Inactive Publication Date: 2021-11-23
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as tissue engineering scaffolds become more and more complex, due to the lack of effective material exchange channels, the cells inside the tissue lack sufficient energy sources, the physiological activity is affected, the survival rate is low, and it is difficult to achieve the purpose of tissue regeneration

Method used

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  • Tissue engineering hydrogel scaffold for promoting cell migration, preparation method of tissue engineering hydrogel scaffold, 3D printing slurry and preparation method of 3D printing slurry
  • Tissue engineering hydrogel scaffold for promoting cell migration, preparation method of tissue engineering hydrogel scaffold, 3D printing slurry and preparation method of 3D printing slurry
  • Tissue engineering hydrogel scaffold for promoting cell migration, preparation method of tissue engineering hydrogel scaffold, 3D printing slurry and preparation method of 3D printing slurry

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Embodiment 1

[0060] The preparation method of the tissue engineering hydrogel scaffold promoting cell migration of the present embodiment is as follows:

[0061] (1) Add 2 g of polyethylene glycol (diol) diacrylate (PEGDA) into 30 ml of ultrapure water, stir for 30 minutes, and fully dissolve it to obtain a polyethylene glycol (diol) diacrylate solution;

[0062] (2) 32mg of photoinitiator I-2959 (2-hydroxyl-4'-(2-hydroxyethoxy)-2-methylpropiophenone) was added to polyethylene glycol (diol) diacrylate solution, Stir for 10 min until completely dissolved to obtain polyethylene glycol (diol) diacrylate / I-2959 solution;

[0063] (3) Slowly add 0.3 g of sodium polyphosphate into the solution of polyethylene glycol (diol) diacrylate / I-2959, stir for 30 minutes until completely dissolved, and obtain polyethylene glycol (diol) diacrylate / I-2959 -2959 / sodium polyphosphate solution;

[0064] (4) Add 3g of sodium alginate to polyethylene glycol (diol) diacrylate / I-2959 / sodium polyphosphate solutio...

Embodiment 2

[0071] (1) Add 2 g of polyethylene glycol (diol) diacrylate (PEGDA) into 30 ml of ultrapure water, stir for 30 minutes, and fully dissolve it to obtain a polyethylene glycol (diol) diacrylate solution;

[0072] (2) Add 16 mg of photoinitiator I-2959 to the polyethylene glycol (diol) diacrylate solution, stir for 10 minutes until completely dissolved, and obtain a polyethylene glycol (diol) diacrylate / I-2959 solution;

[0073] (3) Slowly add 0.9g sodium polyphosphate into polyethylene glycol (diol) diacrylate / I-2959 solution, stir for 30min until completely dissolved to obtain polyethylene glycol (diol) diacrylate / I-2959 solution -2959 / sodium polyphosphate solution;

[0074] (4) Add 1.5g of sodium alginate to polyethylene glycol (diol) diacrylate / I-2959 / sodium polyphosphate solution, stir for 2 hours until completely uniform, and obtain polyethylene glycol (diol) diacrylate Ester / I-2959 / sodium polyphosphate / sodium alginate composite paste, that is, 3D printing paste;

[0075]...

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Abstract

The invention discloses a tissue engineering hydrogel scaffold for promoting cell migration. The tissue engineering hydrogel scaffold is prepared from 1-2 parts of polyethylene glycol (glycol) diacrylate, 8-32 parts of a photoinitiator, 0.15-1.5 parts of polyphosphate and 1.5-3 parts of sodium alginate. The invention further discloses a preparation method of the tissue engineering hydrogel scaffold for promoting cell migration, 3D printing slurry for preparing the tissue engineering hydrogel scaffold for promoting cell migration and a preparation method of the 3D printing slurry. The tissue engineering hydrogel scaffold is good in safety and excellent in mechanical property, meanwhile, the extracellular ATP content can be increased, the physiological activity of cells is promoted, and cell migration is facilitated.

Description

technical field [0001] The invention relates to the field of tissue engineering, in particular to a tissue engineering hydrogel scaffold for promoting cell migration and a preparation method thereof, 3D printing slurry and a preparation method thereof. Background technique [0002] Many diseases and disasters can cause damage to some tissues and organs of the human body. At present, various diseases caused by damage or loss of tissues or organs are the main reasons for endangering human health. With the increase in clinical transplant operations, the demand for organs and tissues has also increased rapidly, but the amount of organ donations is far from meeting the demand. In the United States, 15% of patients waiting for liver and heart transplants die each year due to insufficient donor organs. Although autotransplantations and allotransplantations have achieved remarkable clinical results, this method is at the cost of damaging other healthy parts of the patient's body an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/02A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/18A61L27/20A61L27/025A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00A61L2430/02A61L2300/412C08L71/02C08L5/04
Inventor 杭飞张明豪钱天宝曹子琪王一凡徐扬
Owner SOUTH CHINA UNIV OF TECH
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