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Application of cinnamic acid derivative in preparation of medicine for treating non-alcoholic fatty liver disease

A phenylacrylic acid, non-alcoholic technology, used in the field of medicine, can solve problems such as increased intestinal energy absorption, and achieve the effect of reducing pressure and increasing quantity

Pending Publication Date: 2021-11-16
YUNNAN OPEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metagenomic analysis reveals an increase in genes encoding polysaccharide-decomposing polysaccharides, including glycogen hydrolases, in the gut microbiota of obese mice, leading to increased intestinal energy absorption

Method used

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  • Application of cinnamic acid derivative in preparation of medicine for treating non-alcoholic fatty liver disease
  • Application of cinnamic acid derivative in preparation of medicine for treating non-alcoholic fatty liver disease
  • Application of cinnamic acid derivative in preparation of medicine for treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example provides the application of a phenylacrylic acid derivative with the structural formula shown in Table 1 for the preparation of a drug for the treatment of non-alcoholic fatty liver;

[0029] Involved compound in the embodiment of table 1

[0030]

[0031] In order to further prove the therapeutic effect of the phenylacrylic acid derivatives described in this example on non-alcoholic fatty liver, the following series of verification tests were carried out:

[0032] 1. Effects of phenylacrylic acid derivatives shown in formula I on the blood lipid CHO and TG values ​​of non-alcoholic fatty liver rat model.

[0033] Experimental materials and methods:

[0034] 1. Animals and materials

[0035] 165 SD rats were provided by the Animal Center of Kunming Medical University, weighing 180±20g, free to eat and drink, and kept at 22±2°C. Phenylacrylic acid derivatives are self-made. Silybin capsules were purchased from Tianjin Tasly Pharmaceutical Co., Ltd.

...

Embodiment 2

[0059] The preparation of the phenylacrylic acid derivative tablet shown in formula I: take the phenylacrylic acid derivative shown in formula I and mix it with conventional auxiliary materials, and prepare the phenylacrylic acid derivative tablet shown in formula I according to the conventional method.

[0060]

[0061] Among them, R is H,

Embodiment 3

[0063] Preparation of the oral liquid of the phenylacrylic acid derivative shown in formula I: take the phenylacrylic acid derivative shown in the formula I and mix it with conventional auxiliary materials, and prepare the oral liquid of the phenylacrylic acid derivative shown in the formula I according to a conventional method.

[0064]

[0065] Among them, R is H,

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Abstract

The invention discloses application of a cinnamic acid derivative in preparation of a medicine for treating non-alcoholic fatty liver disease, and belongs to the technical field of medicines. Experiments prove that the cinnamic acid derivative can be used for regulating intestinal flora, increasing the number of Bacteroides bacteria and inhibiting abundance of alpha-proteobacteria; the medicine has a good effect on treating the non-alcoholic fatty liver disease by restoring intestinal micro-ecological balance, wherein the application is disclosed for the first time and has outstanding substantive features. The derivative is applied to preparation of medicines for treating non-alcoholic fatty liver diseases and has a good market application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of a phenylacrylic acid derivative in the preparation of a drug for treating non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) has become an important cause of chronic liver disease in many areas, among which nonalcoholic steatohepatitis (NASH) has the highest incidence. Non-alcoholic steatohepatitis is characterized by patients without a history of alcoholism, but histological changes are similar to alcoholic hepatitis with hepatomegaly and elevated serum transaminases. Severe cases can develop into liver fibrosis, cirrhosis, and even liver cancer. [0003] Studies have shown that the imbalance of intestinal flora structure can lead to the increase of endotoxin in the plasma of the host's circulatory system, induce continuous low-grade inflammation, block the intracellular signaling system of insulin, and lead to insulin resistance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/16A61P1/00
CPCA61K31/192A61P1/16A61P1/00
Inventor 陈晓春
Owner YUNNAN OPEN UNIV
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