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Smartphone imaging analysis system based on finger-pressing type microfluidic platform and application of smartphone imaging analysis system

A smart phone and microfluidic technology, applied in the field of medical testing, to achieve the effect of precise cell identification

Active Publication Date: 2021-11-05
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, complex operating procedures and professional data analysis do not allow the detection of cell deformation to be widely used. High requirements for blood quality and disease prediction, and personalized cell morphology monitoring have become more urgent needs
Smart and popular detectors for cell morphology and structure monitoring remain a challenge

Method used

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  • Smartphone imaging analysis system based on finger-pressing type microfluidic platform and application of smartphone imaging analysis system

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Embodiment 1

[0031] Such as figure 1 As shown, the monitoring of blood cell morphology based on smart acupressure microfluidic / smart phone imaging system includes: inlet part 1 (blood flow inlet of the chip), outlet part 2 (blood flow outlet of the chip), chip chamber 3, micro Hydrogel column 4, circular button part 5, spring part 6, glass spacer 7, optical lens part 8, chip-type LED light source 9, power supply 10, optical lens nesting part 11, microfluidic chip fixed microcolumn Part 12, finger pressure channel part 13, microfluidic chip inlet part 14 (entrance of the 3d printed shell), microfluidic chip outlet part 15 (exit of the 3d printed shell). figure 2 Schematic of blood cell morphology monitoring is shown. The finger pressure is coupled with the red blood cells through the elastically deformable hydrogel, which makes the red blood cells deform regularly. Through the integration of optical lens and SMD LED, intelligently collect and analyze image pixels.

[0032] The microflui...

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Abstract

The invention discloses a smartphone imaging analysis system based on a finger-pressing type microfluidic platform and application of the smartphone imaging analysis system. The system is characterized by comprising a finger-pressing type microfluid based on hydrogel elastic deformation, wherein the finger-pressing type microfluid is used for monitoring the change of the structural strength of blood cells; and the finger-pressing type microfluid and smartphone imaging / analysis are integrated, and erythrocyte counting and roundness and deformability monitoring are achieved by means of smartphone and finger-pressing operation.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a smart phone imaging analysis system based on an acupressure microfluidic control platform and its application. Background technique [0002] Current clinical medicine has high requirements for blood, and the shortage of blood has brought serious challenges to blood supply and public health. Component transfusions are an effective way to address future blood shortages. The required blood components can be provided according to the patient's condition to avoid adverse reactions caused by blood transfusion and save blood resources. Red blood cells (RBCs) are the most widely used components in blood transfusions. However, changes in shape, structure, and function of red blood cells may occur during storage, which may cause clinical complications and adversely affect the mortality of patients. The deformability of erythrocytes is an important parameter to evaluate the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/00G01N15/10
CPCG01N15/00G01N15/10G01N2015/1006G01N2015/103G01N2015/1024G01N15/01
Inventor 杨奕陈龙飞刘彦彤
Owner WUHAN UNIV
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