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Calcium silicate/magnesium silicate biological-bone porous implant as well as preparation method and application thereof

A technology of magnesium silicate and calcium silicate, which is applied in the field of biomedical materials, can solve the problems of limited development, uncontrollable, and non-through hole size, and achieve the goals of promoting bone healing, improving mechanical strength, and good biocompatibility Effect

Pending Publication Date: 2021-10-29
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although traditional manufacturing methods, such as gas foaming method, pore-forming agent method, and freezing, can also produce bone repair scaffolds with a porous structure, defects such as impermeable pores and uncontrollable pore size limit their application in the field of bone repair. development of

Method used

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  • Calcium silicate/magnesium silicate biological-bone porous implant as well as preparation method and application thereof
  • Calcium silicate/magnesium silicate biological-bone porous implant as well as preparation method and application thereof
  • Calcium silicate/magnesium silicate biological-bone porous implant as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0028] like figure 1 Shown, a kind of preparation method of calcium silicate / magnesium silicate biological bone porous implant comprises the following steps:

[0029] Step 1. Slurry preparation: Mix 80g of calcium silicate and 20g of magnesium silicate ceramic powder, add 70g of photosensitive resin and 4g of dispersant, add it to a vacuum mixer and work at a speed of 1200rpm for 20min to obtain a mixed ceramic slurry;

[0030] Step 2, green body preparation: use magics software to draw such as figure 2 The three-dimensional porous structure shown is saved in the format of .STL, and then the model is imported into the photocuring printer, the exposure time is set to 10 seconds, the printing layer thickness is 0.05mm, and then the slurry obtained in step 1 is added, and finally layer by layer Solidify to obtain a three-dimensional porous green body;

[0031] Step 3, degreasing and sintering: put the green body obtained in step 2 into a tubular degreasing furnace for degreasi...

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Abstract

The invention discloses a calcium silicate / magnesium silicate biological-bone porous implant as well as a preparation method and application thereof and belongs to the technical field of biomedical materials. According to the prepared porous implant, a porous matrix is obtained by taking calcium silicate and magnesium silicate as matrixes of the implant, drawing a three-dimensional model through calculation, implementing forming and high-temperature degreasing of a green body by using a digital light treatment technology, and carrying out sintering, a surface coating material is obtained through taking a polyvinyl alcohol solution as a binder and adding polycaprolactone (PCL) powder particles prepared in advance, and the porous implant is finally prepared through placing an implant into the coating material, carrying out sufficient stirring, then, carrying out drying, and then, carrying out heating in a water bath until the PCL is completely molten to the surface. The method can achieve the design of a porous structure, the porous implant has certain biological activity and degradability, can be applied to bone tissue engineering and can be used as a bone filler, a bone repair material or a scaffold for in-vitro cell culture.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a calcium silicate / magnesium silicate biological bone porous implant and a preparation method and application thereof. Background technique [0002] As one of the most important tissues in the human body, the importance of bone is self-evident. In recent years, under the influence of various factors, the number of bone defect cases has reached a new high, and it has become one of the most important diseases that endanger human health. Human bone tissue has a certain self-repair ability, but for bone defects exceeding the critical value, appropriate bone fillers must be used to cooperate with the treatment. Traditional bone repair methods include autologous bone grafting and allogeneic bone grafting, but autologous bone grafting has the problems of secondary injury and limited bone source, while allogeneic bone grafting has the risk of human rejection and disease trans...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/10A61L27/56A61L27/50B33Y70/10B33Y80/00
CPCA61L27/34A61L27/10A61L27/56A61L27/50B33Y70/10B33Y80/00A61L2430/02C08L29/04C08L67/04
Inventor 沈理达张寒旭梁绘昕焦晨何志静
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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