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Application of compound in preparation of medicine with function of improving collateral plexus

A technology of choroid plexus and compounds, which is applied in the fields of health food, food, and medicine, can solve the problems of undiscovered compound applications, achieve the effects of restoring tissue structure and physiological functions, inhibiting proliferation, and treating dementia

Inactive Publication Date: 2021-10-19
CHENGDU FIRST PHARMACEDTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application of the compounds of the present invention in improving the structure of the choroid plexus has not been found so far

Method used

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  • Application of compound in preparation of medicine with function of improving collateral plexus
  • Application of compound in preparation of medicine with function of improving collateral plexus
  • Application of compound in preparation of medicine with function of improving collateral plexus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1. The protective effect of the experimental compound formula 1 on the choroid plexus of a rat model of ischemia-reperfusion injury.

[0069] 1.1 Replication of ischemia-reperfusion model rats

[0070] A. Drugs and reagents

[0071] Experimental compound formula 1 (from Chengdu First Pharmaceutical Co., Ltd.). Chloral Hydrate, Saline

[0072] B. Animals

[0073] Thirty clean-grade healthy Wistar rats, half male and half male, weighing (200±20) g, were provided by the Experimental Animal Center of Shanxi Provincial Hospital of Traditional Chinese Medicine.

[0074] C. Model preparation and processing

[0075] Preparation of the MCAO model group: adopt the suture method to prepare the rat middle cerebral artery embolism model preparation (hereinafter referred to as the MCAO model group), get 24 male and female rats, and use 10% chloral hydrate (35mg / kg) respectively After injecting anesthetized rats, the supine position was fixed, the neck was prepared, the d...

Embodiment 2

[0086] Embodiment 2, experimental compound formula 1 to C 9 h 15 AlO 9 Effects of Inducing Proliferation of Choroid Plexus Epithelial Cells

[0087] Experimental operation method:

[0088] 2.1. Experimental animals

[0089] Twenty-eight 16-day-old clean-grade healthy Wistar rats, half male and half male, weighing (200±20) g, were provided by the Experimental Animal Center of Shanxi Provincial Hospital of Traditional Chinese Medicine.

[0090] 2.2. Experimental materials

[0091] Ultra-clean bench (Suzhou Purification Equipment Co., Ltd.), CO 2 Incubator (Thermo Electron Corporation, USA), IX71 inverted microscope (Olympus Corporation, Japan), confocal laser microscope (Olympus Corporation, Japan), microplate reader (MD Corporation, USA), and flow cytometer (Millipore Corporation, USA). DMEM medium (Wuhan Boster Biological Engineering Co., Ltd.), D-hanks buffer (Wuhan Boster Biological Engineering Co., Ltd.), C 9 h 15 AlO 9 (US Sigma Corporation) and so on.

[0092] 2...

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Abstract

The invention relates to the fields of medicines, health-care foods and foods, and concretely relates to application of a compound in the preparation of a medicine with the function of improving collateral plexus. The compound is shown as a formula (I), can recover normal tissue structures and physiological functions of venation plexus, can also regulate secretion of cerebrospinal fluid, and has a better application effect in the aspect of preparing medicines with the effect of improving the venation plexus.

Description

technical field [0001] The invention relates to the fields of medicine, health food and food, and in particular relates to the application of a compound in the preparation of medicine with the effect of improving the choroid plexus. Background technique [0002] The outermost layer of the choroid plexus of the ventricular system is covered by a layer of ependymal epithelium, which is called the choroid plexus epithelium, which has the functions of material transport and secretion. The central part is a group of capillary network tissue structures surrounded by loose connective surrounded by organizations. The choroid plexus of the lateral ventricle is the main place for the production of cerebrospinal fluid, accounting for about 80%-85% of the total; the choroid plexus is also the main part of the blood-cerebrospinal fluid barrier; Important ventricular structures for transport. The choroid plexus can secrete a variety of growth factors, neurotrophic factors and enzymes, e...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P25/28A61P9/10A61P7/10A61P25/00
CPCA61K31/439A61P25/28A61P9/10A61P7/10A61P25/00
Inventor 刘昭华吴庆江马建强宋艳艳王恒岳永花
Owner CHENGDU FIRST PHARMACEDTICAL CO LTD
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