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Emulsion type organ preserving fluid and preparation method thereof

A technology of organ preservation liquid and emulsion, which is applied in the field of medical materials and can solve the problems of limiting the effective preservation time of organs

Active Publication Date: 2021-10-15
公卫复医(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is worth noting that none of the current organ preservation solutions have oxygen support function, which limits the effective preservation time of organs

Method used

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  • Emulsion type organ preserving fluid and preparation method thereof
  • Emulsion type organ preserving fluid and preparation method thereof
  • Emulsion type organ preserving fluid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In this example, an emulsion-type organ preservation solution is prepared, and the specific process is as follows:

[0039] (1) Prepare oil phase and water phase respectively:

[0040] The preparation method of the oil phase is: weigh 186g of perfluorooctyl bromide, 3.5g of perfluorodecyl bromide, 2g of lactic acid and 44g of lecithin, and make them fully mixed and dissolved by ultrasonic vibration.

[0041] The water phase preparation method is: use pure water as the solvent, the solute includes 0.02mol / L sodium bicarbonate, 0.009mol / L potassium chloride, 0.002mol / L magnesium chloride, 0.000008mol / L calcium chloride, 0.009mol / L hydrochloric acid Amino acid salt, 0.0022mol / L potassium hydrogen 2-ketoglutarate, 0.09mol / L histidine, 0.001mol / L tryptophan, 0.015mol / L mannitol and 0.14mol / L glycerol, fully dissolved.

[0042] (2) Preparation of fluorocarbon milk by microfluidic method: NanoAssemblr TM The platform controls the oil phase and the water phase to flow into th...

Embodiment 2

[0044] In this example, an emulsion-type organ preservation solution is prepared, and the specific process is as follows:

[0045] (1) Prepare oil phase and water phase respectively:

[0046] The preparation method of the oil phase is: weigh 186g of perfluorooctyl bromide, 3.5g of perfluorodecyl bromide, 2g of lactic acid and 44g of lecithin, and make them fully mixed and dissolved by ultrasonic vibration.

[0047] The water phase preparation method is: use pure water as the solvent, the solute includes 0.02mol / L sodium bicarbonate, 0.009mol / L potassium chloride, 0.002mol / L magnesium chloride, 0.000008mol / L calcium chloride, 0.009mol / L hydrochloric acid group Amino acid salt, 0.0022mol / L potassium hydrogen 2-ketoglutarate, 0.09mol / L histidine, 0.001mol / L tryptophan, 0.015mol / L mannitol, 0.14mol / L glycerin.

[0048] (2) Micro-jet high-pressure homogenization method to prepare fluorocarbon emulsion: mix the oil phase and water phase at a volume ratio of 1:10, cut at 10,000 rpm ...

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Abstract

The invention discloses an emulsion type organ preserving fluid and a preparation method thereof. The emulsion type organ preserving fluid comprises an oil phase component and a water phase component; the oil phase component comprises a fluorocarbon alkane oxygen carrying agent, an emulsifier and lactic acid; the water phase component comprises an osmotic pressure regulator, a buffer salt, an electrolyte and carbonate; and the volume ratio of the oil phase component to the water phase component is 1: (3-20). The oil phase and the water phase are mixed through a micro-fluidic method or a micro-jet high-pressure homogenization method, and the emulsion type organ preserving fluid which is appropriate in particle size, high in stability and high in oxygen carrying capacity is prepared. The emulsion type organ preserving liquid can prolong the organ preservation time and improve the organ preservation quality.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to an emulsion-type organ preservation solution and a preparation method thereof. Background technique [0002] With the development of organ transplantation technology, more and more attention is paid to organ preservation technology. High-quality donor organs are the prerequisite for successful organ transplantation, and organ preservation technology is the cornerstone of organ transplantation. Organ transplantation must transplant living organs, and the organs for transplantation need to maintain their complete anatomical structure and activity from the moment they are cut out of the donor until their main blood vessels are connected to the patient's blood vessels. However, once any organ loses blood supply, the cells cannot get the necessary oxygen and nutrients, and will die in a short period of time at room temperature. Therefore, it is necessary to find ways to m...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0226A01N1/0247
Inventor 巫国谊刘瑜朱同玉
Owner 公卫复医(上海)生物科技有限公司
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