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Detection method related to human papilloma virus infection immune response and application

A technology of human papillomavirus and immune response, which is applied in the field of biomedicine to achieve the effect of assisting clinical detection and testing, with simple methods and clear results

Pending Publication Date: 2021-10-12
新疆自治区人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no detailed comparison of HPV single-time and persistent infection has been reported

Method used

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  • Detection method related to human papilloma virus infection immune response and application
  • Detection method related to human papilloma virus infection immune response and application
  • Detection method related to human papilloma virus infection immune response and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 The risk of persistent HPV16 infection is lower in Uighur women than in Han women

[0034] 210 samples were collected, including 90 cases of transient infection and 120 cases of persistent infection. Among the patients with transient infection, there were 75 cases of Han nationality, of which 76% (57 / 75) were infected with HPV16 type; 15 cases of Uyghur nationality, of which 73.3% (11 / 15) were infected with HPV16 type; among the patients with persistent infection, 95 cases were of Han nationality , of which 77.9% (74 / 95) were HPV16 infection; 25 Uighur cases, of which 64% (16 / 25) were HPV16 infection. Persistent HPV16 infection, the proportion of Han women is higher than that of Uyghur women.

[0035] Table 1 Collection of samples meeting the screening criteria in 2017-2018 (example)

[0036]

Embodiment 2

[0037] Example 2 Uyghur women are more likely to cause cervical cancer and the degree is more serious than Han women when the viral load is significantly lower than that of Han women

[0038] In patients with transient and persistent infection, the viral load of HPV positive patients in Han nationality (682.8.3±231.6; 488.4.3±289.6) was significantly higher than that in Uygur nationality (228.3±174.7; 287.2±189.7) (P<0.05) . Combined analysis with my team's research data on cervical cancer of Uyghur women in Xinjiang in the past 10 years, it is found that Uyghur women are more likely to cause cervical cancer and the degree is more serious than Han women when the viral load is significantly lower than that of Han women.

Embodiment 3

[0039] Example 3 CD86 expression in Uygur women is significantly lower than that in Han women in transient infection

[0040] In peripheral blood DC cell surface markers, there was no significant difference in the expression of CD11c in Han nationality (13.2±3.942; 7.999±3.266)% and Uygur nationality (7.46±0.17; 11.83±2.012)% in transient and persistent infection ( P>0.05); CD86 expression was significantly higher in Han nationality (16.84±3.871)% than in Uygur nationality (2.40±1.380)% in transient infection (P0.05) . There was no significant difference in HLA-DR expression in Han (21.45±4.645; 22.25±4.190)% and Uygur (17.37±3.926; 27.37±6.436)% (P>0.05).

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PUM

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Abstract

The invention belongs to the technical field of biomedicine, and relates to a detection method related to human papilloma virus infection immune response and application. The invention provides a novel method for detecting HPV (human papillomavirus) infection. The novel method comprises the step of detecting virus load, DC (dendritic cell) mature state in peripheral blood or T lymphocyte subpopulation and NK (natural killer) cell surface markers. A combined detection technology of DC cells, T lymphocytes and NK cells is adopted for detecting the immune response state of a host after HPV infection, and the invention further provides the application of the detection method. The detection method disclosed by the invention is simple and convenient in detection and clear in result, and can be applied to the clinical auxiliary detection and inspection of the HPV and even the cervical cancer and to screen the HPV and even the cervical cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a detection method for HPV-infected host non-specific immune response and immunosuppression, in particular to a detection method and application related to human papillomavirus infection immune response. Background technique [0002] The prior art discloses that cervical cancer is one of the most common gynecological malignancies in women all over the world. According to statistics, there are about 530,000 new cases of cervical cancer every year in the world, and about 270,000 deaths every year. At present, 85% of cervical cancer cases occur in developing countries. Among them, China has more than 137,000 new cases every year, accounting for 28.8% of the world's total. Xinjiang is one of the high-incidence areas of cervical cancer in my country. Uighur women in southern Xinjiang have a high incidence and mortality rate of cervical cancer, and the mortality rate ranks first among...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/569
CPCG01N33/6872G01N33/56972G01N33/56977G01N33/56983
Inventor 玛依努尔·尼牙孜朱开春伊力努尔·哈力甫韩莉莉阿依米热·艾山江马春华陈红香祖木热来提·艾尼瓦尔
Owner 新疆自治区人民医院
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