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Method for detecting content of bromodiphenyl methane in ebastine medicine

A technology of diphenylbromethane and ebastine, which is applied in the field of analysis and detection of ebastine drugs, can solve the problems of residual diphenylbromethane, etc., and achieve the effects of good specificity, high sensitivity and good repeatability

Pending Publication Date: 2021-10-01
杭州微源检测技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the method for synthesizing ebastine usually uses diphenylbromomethane as a raw material, which may cause a certain amount of diphenylbromethane to remain in the obtained ebastine

Method used

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  • Method for detecting content of bromodiphenyl methane in ebastine medicine
  • Method for detecting content of bromodiphenyl methane in ebastine medicine
  • Method for detecting content of bromodiphenyl methane in ebastine medicine

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Embodiment Construction

[0022] A method for detecting diphenylbromethane content in ebastine medicine, comprising the following steps:

[0023] Solution preparation:

[0024] Reference substance stock solution: Weigh about 37.5mg of diphenylbromomethane reference substance, put it in a 100mL measuring bottle, dilute to the mark with n-hexane, and shake well;

[0025] Reference substance solution (STD): Accurately measure 2mL of the reference substance stock solution, put it in a 25mL measuring bottle, add n-hexane to dilute to the mark, and shake well to obtain (300ng / mL);

[0026] 200% linear solution: Accurately measure 4mL of the reference substance stock solution, put it in a 25mL measuring bottle, add n-hexane to dilute to the mark, and shake well;

[0027] 150% linear solution: Accurately measure 3mL of the reference substance stock solution, put it in a 25mL measuring bottle, add n-hexane to dilute to the mark, and shake well;

[0028] 100% linear solution: Accurately measure 2mL of the refe...

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Abstract

The invention relates to a method for detecting the content of bromodiphenyl methane in an ebastine medicine, which comprises the following steps of: 1, preparing a test solution by taking an ebastine raw material medicine and taking n-hexane as a solvent, and dissolving and diluting bromodiphenyl methane with n-hexane to prepare a reference solution; and 2, carrying out gas chromatographic analysis by taking a dimethyl polysiloxane column as a chromatographic column. According to the method for detecting the content of the bromodiphenyl methane in the ebastine medicine, gas chromatography is used for detection, and the method has the advantages of being good in specificity, high in sensitivity, good in repeatability and the like and can be widely used for detecting the content of the bromodiphenyl methane in the ebastine medicine.

Description

technical field [0001] The embodiments of the present invention belong to the technical field of analysis and detection of ebastine, and specifically relate to a method for detecting the content of diphenylbromethane in ebastine. Background technique [0002] Ebastine is a potent, long-acting and highly selective histamine H1 receptor blocker, which has a rapid and long-lasting histamine inhibitory effect, and has a strong affinity for histamine H1 receptors, It is a very commonly used antihistamine in clinical practice. It has a good effect on some allergic diseases. It is also used clinically for allergic rhinitis, seasonal rhinitis, urticaria, etc. [0003] At present, the method for synthesizing ebastine usually uses diphenylbromomethane as a raw material, which may cause a certain amount of diphenylbromethane to remain in the obtained ebastine. [0004] In order to ensure the purity and effect of ebastine, it is of great significance to analyze and control the content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/70
CPCG01N30/06G01N30/70G01N2030/025
Inventor 文杨明潜晓龙毛赟杰
Owner 杭州微源检测技术有限公司
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