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188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and preparation method thereof

A nanoprobe, 188re technology, applied in the field of tumor treatment, can solve the problem of not significantly prolonging the survival time of patients

Pending Publication Date: 2021-10-01
GENERAL HOSPITAL OF NUCLEAR IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have confirmed that excessive lymph node dissection does not significantly prolong the survival of patients

Method used

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  • 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and preparation method thereof
  • 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and preparation method thereof

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Experimental program
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Embodiment 1

[0025] 188 Re-labeled degradable nanoprobes for breast cancer diagnosis and treatment. The nanoprobes are composed of PLGA nanoparticles loaded with IDO inhibitors. The nanoprobes include the following components according to the molar mass: lactide 4mol, glycolide 1mol, octanoic acid stannous, surfactant PIC-PEO, IDO inhibitor and dispersant PEG, the nanoprobe is linked with folic acid for targeting 4T1 breast cancer, and linked with 188 Re is used for targeted tracking of breast cancer and lymph node metastasis, SPECT imaging and internal radiation sensitization therapy.

[0026] The preparation method is as follows: S1) mixing lactide and glycolide, adding an initiator, melting and ring-opening polymerization under vacuum conditions to obtain PLGA; S2) dissolving PLGA and surfactant in IDO inhibitor, adding Dispersant, by controlling the microfluidic extrusion speed to make nanoprobes; S3) connecting folic acid on the nanoprobes;

[0027] S4) connection on the nanoprobe ...

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Abstract

The invention discloses a 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment and a preparation method, the 188Re-labeled degradable nano-probe for breast cancer diagnosis and treatment comprises a nano-probe, and the nano-probe is formed by coating an IDO inhibitor with PLGA nano-particles, the nano-probe comprises the following components by molar mass: 4-6 mol of lactide, 1-2 mol of glycolide, an initiator, a surfactant, an IDO inhibitor and a dispersant, the nano-probe is connected with folic acid for targeting 4T1 breast cancer, and is connected with 188Re for targeted tracking of breast cancer and lymph node metastasis, SPECT imaging and internal irradiation sensitization treatment. The degradable nano-probe disclosed by the invention can realize targeted tracking, SPECT imaging and internal irradiation sensitization precise treatment of breast cancer and lymph node metastasis, and realizes diagnosis and treatment integration of breast cancer.

Description

technical field [0001] The invention relates to the technical field of tumor treatment, in particular to 188 Re-labeled degradable nano-probe for diagnosis and treatment of breast cancer and preparation method. Background technique [0002] Breast cancer is the female tumor with the first incidence rate and the second mortality rate, which seriously endangers women's life, health and quality of life. One of the main reasons for the high mortality rate of breast cancer is that the early detection rate is low, often diagnosed in the middle and late stages, and the best treatment opportunity is lost. Therefore, accurate early diagnosis of breast cancer is of great significance. [0003] X-ray mammography, breast ultrasound and breast magnetic resonance (MRI) examinations are the most commonly used methods for clinical diagnosis of breast cancer. However, these diagnostic methods have certain defects, such as: X-ray mammography examination is not easy to detect small tumors w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/06A61K51/04A61K51/12A61K41/00A61P35/00A61P15/14C08G63/08C08G63/85
CPCA61K51/06A61K51/0459A61K51/1244A61K41/0038A61P35/00A61P15/14C08G63/08C08G63/823
Inventor 孙兴伟
Owner GENERAL HOSPITAL OF NUCLEAR IND
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