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Application of nicotinic acid in preparation of medicine for treating and/or preventing fertility disorder of obese women

A technology of niacin and obesity, which is applied in the field of medicine to achieve the effect of reducing the abnormal rate

Pending Publication Date: 2021-09-21
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies of the prior art, the technical problem to be solved by the present invention is: aiming at female fertility problems such as the decline in the quality of eggs and early embryos caused by metabolic diseases such as obesity; providing a new use of niacin: niacin is effective in preventing and / or or in the treatment of decreased egg and embryo quality in obese women

Method used

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  • Application of nicotinic acid in preparation of medicine for treating and/or preventing fertility disorder of obese women
  • Application of nicotinic acid in preparation of medicine for treating and/or preventing fertility disorder of obese women
  • Application of nicotinic acid in preparation of medicine for treating and/or preventing fertility disorder of obese women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 constructs obese mouse model

[0043] Three-week-old female ICR mice were randomly divided into two groups, fed with high fat diet (HFD) and normal diet (ND), respectively, and had free access to food and water. After 16 weeks of feeding, the average body weight of HFD mice was significantly higher than that of ND mice (54.3±4.9g vs. 38.3±2.7g, P<0.05), and the fasting blood glucose level of HFD mice was significantly higher than that of ND mice (8.8 ±1.4mM vs.4.6±0.9mM, P<0.05), which indicated that the obese mice were successfully modeled. ND mice served as controls.

Embodiment 2

[0044] Embodiment 2 Configuration of oocyte maturation medium in vitro

[0045] The culture medium for in vitro maturation of obese mouse oocytes was based on the M16 medium (Sigma, Cat. No. M7292) with the addition of niacin (nicotinic acid, NA) at a concentration of 50 μM. M16 culture medium without niacin was used as a control.

Embodiment 3

[0046] Example 3 Obtaining and in vitro maturation culture of obese mouse oocytes

[0047] Obese mice were euthanized and ovaries were removed 48 hours after intraperitoneal injection of 5 IU of pregnant horse serum gonadotropin. The antral follicles on the surface of the ovary were punctured with a needle tip to obtain oocytes at the GV stage, which were cultured in the culture medium described in Example 2 for 14 hours.

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PUM

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Abstract

The invention discloses application of nicotinic acid in preparation of a medicine for treating and / or preventing fertility disorder of obese women, and belongs to the technical field of medicines. According to the invention, through in-vivo supplement or in-vitro addition of nicotinic acid, fertility of obese women can be effectively improved, abnormal assembly proportion and oxidative stress level of meiosis devices in mature ova are reduced, and early embryos after fertilization are promoted to develop to blastocyst stage; the method is of great significance to prevention and / or treatment of female infertility caused by obesity. Nicotinic acid is an important endogenous substance in an organism, is very stable in structure and property, low in price and easy to obtain, and can play a role when being supplemented in vivo or added in vitro, so that the nicotinic acid is very high in practicability when being used as a medicine or a biological preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of nicotinic acid in preventing and / or treating the decline of egg and embryo quality in obese women. Background technique [0002] Statistics from the World Health Organization show that as of 2016, about 13% of adults worldwide (15% of the female population) suffer from obesity. The number of obese people in China has reached more than 250 million in 2019. This chronic metabolic disease caused by multiple factors has become a major health problem in today's society. Moreover, a large number of studies have shown that obese women in the childbearing age group are prone to reproductive problems such as pregnancy failure, miscarriage, premature birth and fetal birth defects. Among them, the decline in the quality of oocytes and early embryos is an important reason. Obesity can lead to a variety of abnormal phenotypes in eggs and early embryos after f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4406A61P15/00A61P3/04A61P15/08C12N5/073C12N5/075
CPCA61K31/4406A61P15/00A61P3/04A61P15/08C12N5/0609C12N5/0604C12N2500/30
Inventor 王强祝帅葛娟
Owner NANJING MEDICAL UNIV
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