Bioactive degradable magnesium alloy guided bone regeneration membrane and processing method of dense holes of bioactive degradable magnesium alloy guided bone regeneration membrane

Abstract

The invention relates to a bioactive degradable magnesium alloy guided bone regeneration membrane and a processing method of dense holes of the bioactive degradable magnesium alloy guided bone regeneration membrane. The bioactive degradable magnesium alloy guided bone regeneration membrane comprises a barrier membrane, the shape of the barrier membrane is attached to bone tissue around a defect area, the barrier membrane is divided into an upper part and a lower part, a skeleton structure area and through hole areas arranged regularly are designed on the barrier membrane, and the arrangement rule of the through holes is that the through holes are distributed alternately in a sparse and dense mode; and the framework structure is not provided with through holes, the through hole area comprises a plurality of circular areas of 0.5-5 mm, a plurality of dense holes smaller than or equal to 0.2 mm are evenly distributed in the circular areas, and the distance between the dense holes is adjusted according to the corrosion rate of actually used materials and the required corrosion effect. The barrier membrane further comprises blind holes with the depth ranging from 0.05 mm to 0.25 mm, and medicine is loaded at the blind holes. According to the invention, the through holes can achieve the effects of discharging degraded gas, penetrating body fluid, nutrient substances and red blood cells and hindering soft tissue cells from penetrating through the holes; dense holes in the through hole area mainly play a role in preventing early-stage soft tissue from growing in, and can be degraded and release magnesium ions to play a role in osteogenesis while being implanted; and a skeleton structure is designed on the barrier membrane, no through hole is arranged in the skeleton structure, surface modification and slow degradation can be achieved, the mechanical supporting effect of the barrier membrane in the bone repairing process is maintained, and the technical problems that materials between through holes of an existing barrier membrane are rapidly degraded, the whole barrier membrane loses mechanical supporting too early after the through holes are connected, and bone defect area repairing is not facilitated can be solved.

Description

technical field [0001] The invention belongs to the technical field of oral medical devices, and in particular relates to a bioactive degradable magnesium alloy guiding bone regeneration film and a processing method for dense pores thereof. Background technique [0002] Periodontal disease is currently one of the most common oral diseases, and the number of patients continues to grow. Periodontal disease can lead to damage to periodontal ligament and gingival tissue, and in severe cases, it may lead to tooth loss and alveolar bone resorption in patients, especially elderly patients. If the amount of alveolar bone is insufficient, operations such as oral implants cannot be performed. Therefore, in this case, the alveolar bone defect area needs to be reconstructed first. With the development of degradable medical metal materials and medical technology, guided bone regeneration (GBR) and guided tissue regeneration (GTR) technologies have become the hotspots of bone augmentatio...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a bioactive degradable magnesium alloy guided bone regeneration membrane, which overcomes the design of the barrier membrane in the prior art because the size of the through hole will affect the migration of soft tissue cells and the degradation rate of the barrier membrane. Too large pore size will cause soft tissue cells to grow into the bone defect area, hindering bone tissue repair; too small pore size will cause the gas generated by the degradation of the barrier membrane to be unable to be discharged smoothly, and the processing difficulty will increase; and the designed through holes are basically arranged in the entire barrier membrane In general, there is no rule of density distribution, which leads to rapid degradation of the material between the through holes of the barrier membrane, and the interconnection of the through holes makes the entire barrier membrane lose its mechanical support prematurely, which is not conducive to the repair of bone defect areas and other technical problems

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