Preparation method and application of high-adhesion composite functional hydrogel

A technology with multiple functions and high adhesion, which is applied in the fields of pharmaceutical formula, medical science, bandages, etc., can solve the problems of single function and insufficient mechanical properties, and achieve the effect of simple preparation process, good anti-oxidation, and promotion of wound healing

Pending Publication Date: 2021-09-10
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the above-mentioned problems existing in the prior art, the present invention provides a preparation method and its application of a highly adhesive composite functional hydrogel, which overcomes the single function and insufficient mechanical properties of the existing hydrogel. Defects, with suitable gelling time, ultra-high water content, swelling rate, good antioxidant, antibacterial, hemostatic, self-healing ability, can significantly promote wound healing

Method used

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  • Preparation method and application of high-adhesion composite functional hydrogel
  • Preparation method and application of high-adhesion composite functional hydrogel
  • Preparation method and application of high-adhesion composite functional hydrogel

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Embodiment 1

[0047] see image 3 , Figure 8 , Figure 9 , Figure 10 as well as Figure 12, the first embodiment of the present invention is based on acute skin injuries, such as mechanical injuries such as sharp and blunt injuries and surgical bleeding wounds, as well as bleeding wounds that damage active joints. First, use hyaluronic acid grafted dopamine and chitosan quaternary ammonium salt to mix evenly in proportion, then add hydrogen peroxide and horseradish peroxidase to each tube, stir evenly, let it stand for gelation, and apply it on the the wound. The specific steps are:

[0048] 1. Oxidized hyaluronic acid (OHA): First, weigh 1g of HA on the balance and add it to the conical flask; add 100mL of deionized water, put it into the rotor, and stir it on a magnetic stirrer for 3 hours, showing an obvious transparent gel. Then, take 0.54g of sodium periodate and dissolve it in 5ml of deionized water, add it dropwise to the HA solution, stir in the dark, and after stirring for ...

Embodiment 2

[0054] see image 3 , Figure 8 , Figure 9 and Figure 10 , The second embodiment of the present invention is applied to bioadhesives, such as fixing electronic products such as wearing medical devices and sensors to the skin, so as to observe and treat acute skin damage. The hydrogel prepared by this method shows long-term and reproducible adhesion properties to the skin, and compared with the conventional organic elastomer matrix, this hydrogel has similar physiological and mechanical properties to human skin. Especially this hydrogel can be tightly adhered and easily peeled off without residue on the skin surface. The method of use is that after the hydrogel is formed into a gel, the related products can be adhered to the skin. The specific steps are:

[0055] 1. Oxidized hyaluronic acid (OHA): First, weigh 1g of HA on the balance and add it into the conical flask; add 100mL of deionized water, put it into the rotor, and stir on the magnetic stirrer for 3 hours; It c...

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Abstract

The invention discloses a preparation method and application of high-adhesion composite functional hydrogel, and the method comprises the following steps: modifying hyaluronic acid grafted dopamine, uniformly mixing with quaternary ammonium salt chitosan according to a volume ratio of 1: 1, and carrying out catalytic crosslinking by using hydrogen peroxide and horse radish peroxidase to form gel. The hydrogel can be used for constructing a multifunctional hydrogel dressing at an acute skin injury focus, and can also be applied to a biological adhesive. The hydrogel not only has adhesion performance, but also has appropriate gelling time, ultrahigh water content and swelling rate, good antioxidant, antibacterial, hemostatic and self-healing capabilities, and can remarkably promote wound healing.

Description

technical field [0001] The invention relates to the preparation technology of skin wound dressing, in particular to a preparation method and application of a high-adhesive composite functional hydrogel. Background technique [0002] Poor healing of acute skin injuries is a serious healthcare problem, and hydrogels have emerged in recent years with many advantages as novel wound dressings. There are many researches and products on the application of hydrogel dressings to wound healing, and some hydrogels have been applied to clinical or commercial production. However, the hydrogel dressings currently prepared to promote wound healing either have relatively simple functions, or the mechanical properties of the hydrogel itself are insufficient, which cannot meet the requirements of an ideal hydrogel wound dressing. This is mainly due to the single function of the hydrogel material itself and the crosslinking method of the hydrogel. It is a simple and effective method to obtai...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08A61L26/00
CPCC08J3/075A61L26/008A61L26/0066A61L26/0061A61L26/0023A61L2400/04A61L2300/404A61L2300/418A61L2300/208A61L2300/232C08J2305/08C08J2405/08C08L5/08
Inventor 张琨李建康崔龙龙李敬安
Owner ZHENGZHOU UNIV
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