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Ferrocenyl metal organic framework nanoparticle and preparation method thereof

An organic framework and base metal technology, applied in the field of medicine, can solve the problems of unfavorable intravenous administration and large particle size, and achieve the effects of high photothermal conversion efficiency, small particle size and good stability.

Active Publication Date: 2021-09-10
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The currently reported ferrocene-based metal organic framework photothermal nanomaterials, such as Zr-Fc MOF nanosheets, have excellent photothermal conversion efficiency, but the particle size is large, which is not conducive to intravenous administration. Therefore, we use chloride Copper dihydrate and 1,1'-ferrocenedicarboxylic acid prepared ferrocene-based metal-organic framework nanoparticles with an average particle size of 100-260nm

Method used

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  • Ferrocenyl metal organic framework nanoparticle and preparation method thereof
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  • Ferrocenyl metal organic framework nanoparticle and preparation method thereof

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Embodiment 1

[0017] This embodiment is a preparation method of ferrocene-based metal-organic framework nanoparticles, including the following steps:

[0018] Dissolve 0.58g of polyvinylpyrrolidone in 4mL of N,N-dimethylformamide, then add 0.034g of copper chloride dihydrate and 0.055g of 1,1'-ferrocenedicarboxylic acid respectively, and dissolve the reaction solution Transfer to a reaction vessel, react at 120° C. for 10 h, centrifuge, and wash with N,N-dimethylformamide and water three times to obtain ferrocene-based metal-organic framework nanoparticles.

Embodiment 2

[0020] This embodiment is a preparation method of ferrocene-based metal-organic framework nanoparticles, including the following steps:

[0021] Dissolve 0.58g of polyvinylpyrrolidone in 4mL of N,N-dimethylformamide, then add 0.034g of copper chloride dihydrate and 0.055g of 1,1'-ferrocenedicarboxylic acid respectively, and dissolve the reaction solution Transfer to a reaction vessel, react at 125° C. for 5 h, centrifuge, and wash with N,N-dimethylformamide and water three times to obtain ferrocene-based metal-organic framework nanoparticles.

Embodiment 3

[0023] This embodiment is a preparation method of ferrocene-based metal-organic framework nanoparticles, including the following steps:

[0024] Dissolve 1.16g of polyvinylpyrrolidone in 9mL of N,N-dimethylformamide, then add 0.070g of copper chloride dihydrate and 0.110g of 1,1'-ferrocenedicarboxylic acid respectively, and dissolve the reaction solution Transfer to a reaction vessel, react at 120° C. for 5 h, centrifuge, and wash with N,N-dimethylformamide and water three times to obtain ferrocene-based metal-organic framework nanoparticles.

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Abstract

The invention discloses a ferrocenyl metal organic framework nanoparticle and a preparation method thereof. The ferrocenyl metal organic framework nanoparticle with the photo-thermal conversion effect and the Fenton effect is prepared from copper chloride dihydrate, 1,1'-ferrocenedicarboxylic acid and polyvinylpyrrolidone. The average particle size of the ferrocenyl metal organic framework nanoparticle is 100-260 nm; the preparation method is simple; and the ferrocenyl metal organic framework nanoparticle has good stability and biocompatibility. Under laser irradiation, the ferrocenyl metal organic framework nanoparticle has good photo-thermal conversion efficiency and photo-thermal stability; under a weak acidic condition, Fenton or Fenton-like reaction can be carried out to generate hydroxyl free radicals; and the ferrocenyl metal organic framework nanoparticle has a wide application prospect when being applied to photothermal therapy and chemokinetic therapy of tumours.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ferrocene-based metal-organic framework nanoparticle and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases threatening human life and health, and its morbidity and mortality have increased year by year in recent years. In recent years, photothermal therapy (PTT) based on near-infrared light (NIR) for tumor therapy has attracted much attention. Photothermal therapy is a new tumor treatment method that uses photothermal materials with photothermal conversion efficiency to generate high temperatures under near-infrared light irradiation to kill cancer cells. The current photothermal materials are mainly divided into four categories, the first category is metal-based nano-photothermal conversion materials; the second category is carbon-based photothermal conversion materials; the third category is organic polymer photother...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/34A61K33/26A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00C08G83/00
CPCA61K33/26A61K33/34A61K41/0052A61K9/0009A61P35/00B82Y5/00B82Y30/00B82Y20/00B82Y40/00A61K41/0042C08G83/008A61K2300/00
Inventor 张良珂杨嘉慧
Owner CHONGQING MEDICAL UNIVERSITY
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