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Graphdiyne-heme nano-composite as well as preparation method and application thereof

A nanocomposite and graphyne technology, applied in the field of biomedicine, can solve the problems of reduced catalytic activity and limited applications

Inactive Publication Date: 2021-09-10
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the heme molecule has high hydrophobicity, and it is easy to agglomerate in aqueous solution, which greatly reduces its catalytic activity, thus limiting its application in biomedicine.

Method used

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  • Graphdiyne-heme nano-composite as well as preparation method and application thereof
  • Graphdiyne-heme nano-composite as well as preparation method and application thereof
  • Graphdiyne-heme nano-composite as well as preparation method and application thereof

Examples

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Effect test

preparation example 1

[0051] This preparation example provides a kind of graphyne-heme nanocomposite, and its preparation method is as follows:

[0052] (1) Dissolve 5mg of graphyne (GDY) powder in 10mL of ultrapure water, 500W ultrasonic treatment for 4h, to obtain graphyne dispersion; dissolve 5mg of heme (Hemin) in 10mL of ammonia solution (25%), add 20mg NaOH powder was magnetically stirred at a speed of 500 rpm for 10 min at 25°C to obtain a heme solution;

[0053] (2) Add the heme solution to the graphdiyne dispersion, and magnetically stir at a speed of 500 rpm at 25°C for 20 minutes to obtain the dispersion I;

[0054] (3) Transfer the dispersion I in step (2) to an oil bath, magnetically stir at 500 rpm at 80°C for 5 minutes, add 15 μL of hydrazine hydrate, and continue stirring for 4 hours to obtain dispersion II;

[0055] (4) Collect the dispersion II into a centrifuge tube, centrifuge at 16000 g for 10 min, discard the supernatant, add ultrapure water to wash, a total of 3 times;

[0...

Embodiment 1

[0058] The graphdiyne-heme nanocomposite (GDY-Hemin) that preparation example 1 makes is carried out transmission electron microscope observation, the result is as follows figure 1 shown by figure 1 It can be seen that the prepared GDY-Hemin has a two-dimensional sheet structure.

Embodiment 2

[0060] The graphdiyne-heme nanocomposite (GDY-Hemin) that preparation example 1 makes utilizes dynamic light scattering instrument to measure its hydrated particle diameter, and the result is as follows figure 2 shown by figure 2 It can be seen that the peak of the hydrated particle size is 160 nm.

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Abstract

The invention relates to a graphdiyne-heme nano-composite as well as a preparation method and application thereof. The graphdiyne-heme nano-composite comprises graphdiyne nanosheets and heme loaded through hydrophobic interaction and pi-pi conjugation. According to the graphdiyne-heme nano-composite disclosed by the invention, the graphdiyne nanosheets with good water solubility are creatively used for loading heme molecules through hydrophobic interaction and pi-pi conjugation, so that the water solubility and dispersity of the heme are improved. The graphdiyne-heme nano-composite retains the efficient catalytic performance of heme, has high peroxidase activity, can catalyze hydrogen peroxide to generate a large number of hydroxyl radicals under a weak acid condition, has an efficient killing effect on gram-positive bacteria and gram-negative bacteria, can treat bacterial infection of wounds, and can accelerate the wound healing. Meanwhile, the graphdiyne-heme nano-composite also has good biocompatibility and is easy to apply in biomedicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a graphyne-heme nanocomposite and a preparation method and application thereof. Background technique [0002] Bacterial infection has been one of the major diseases threatening human health for thousands of years. Since the discovery of penicillin in 1929, antibiotics have become the most important means for humans to fight against bacterial infections, and are widely used in modern medicine. However, with the large-scale use of antibiotics, bacterial resistance to antibiotics is also rising sharply, posing a great threat to global public health security. Therefore, human beings began to work hard to find and develop alternatives to antibiotic treatment. [0003] In recent years, nano-antibacterial treatment has attracted people's attention due to its excellent antibacterial properties and good biological safety, including the use of the physical properties of nanomaterials t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/42A61K47/52A61P17/02A61P31/04B82Y5/00B82Y30/00B82Y40/00
CPCA61K38/42A61K47/52A61P31/04A61P17/02B82Y5/00B82Y30/00B82Y40/00
Inventor 陈春英阿巴卜·阿立刘佳明周会鸽刘涛
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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