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Application of Fascaplysin compound

A compound and drug technology, applied in the field of medicine, to achieve the effect of promoting cell death and increasing the concentration of iron ions

Inactive Publication Date: 2021-09-03
GUANGDONG ZHANJIANG PROVINCIAL LAB OF SOUTHERN MARINE SCI & ENG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the role of marine natural products in ferroptosis

Method used

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  • Application of Fascaplysin compound
  • Application of Fascaplysin compound
  • Application of Fascaplysin compound

Examples

Experimental program
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Embodiment Construction

[0026] The technical solutions of the present invention will be further described below in conjunction with specific examples. The raw materials used in the following examples, unless otherwise specified, can be obtained from conventional commercial channels; the processes used, unless otherwise specified, are conventional processes in the art.

[0027] Taking a Fascaplysin compound Mar-03 as an example, the study of its induction effect on cell ferroptosis includes the following steps:

[0028] (1) Culture and passage of A549 cells

[0029] 10% (v / v) fetal calf serum and 1% (v / v) double antibody were added to the H1640 medium to serve as a complete culture medium for non-small cell lung cancer cell A549. Resuspend and mix with complete culture solution, place in a sterile culture bottle at 37°C, 5% CO 2 Cultured in an incubator, and subcultured when the cells adhered to the wall and almost covered the bottom of the culture flask. When subculture, first suck out the old med...

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Abstract

The invention discloses application of a Fascaplysin compound, and particularly relates to application of the Fascaplysin compound in preparation of a ferroptosis inducer, a medicine for improving the concentration of iron ions in cells and an anti-tumor medicine. The Fascaplysin compound can induce the occurrence of ferroptosis, regulates the death of non-small cell lung cancer cells in a novel mode of promoting cell death, can improve the concentration of the iron ions in the cells, is an effective ferroptosis inducer, and can be used for preparing and developing the anti-lung cancer medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a Fascaplysin compound. Background technique [0002] Ferroptosis is a new type of cell death whose mechanism is independent of apoptosis and other methods. It was discovered in 2003 by Dolma and other high-throughput screening of the lethal effects of more than 20,000 compounds. The targeted killing HRas induced by Erastin A new iron-dependent cell death mode of overexpressed tumor cells is quite different from classic cell death modes such as apoptosis, necrosis and autophagy in terms of morphology and biochemistry. In 2012, Dixon named this method of cell death ferroptosis. When ferroptosis occurs in cells, the mitochondria in the cytoplasm will condense, the inner membrane cristae will decrease or even disappear, the outer membrane will increase in density and rupture, and the active ferrous ions in the cell will increase. Finally, fatal lipid peroxides w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P35/00A61P29/00A61P25/28A61P9/00A61P3/10A61P11/00A61K35/655
CPCA61K35/655A61K31/437A61P35/00A61P29/00A61P25/28A61P9/00A61P3/10A61P11/00
Inventor 罗连响罗辉许广香黄芳芳李晓玲
Owner GUANGDONG ZHANJIANG PROVINCIAL LAB OF SOUTHERN MARINE SCI & ENG
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