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Cosmetic or dermatological composition as well as preparation method and application thereof

A dermatology and composition technology, applied in the direction of cosmetic preparations, cosmetics, skin diseases, etc., can solve the problems of low bioavailability, poor skin absorption, low solubility, etc., to expand the gap between keratinocytes and distribute evenly , good compatibility effect

Active Publication Date: 2021-08-10
泉州达浔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, triterpene acids belong to drugs with low solubility and low permeability. For example, asiatic acid and ursolic acid belong to the fourth class of drugs according to the biopharmaceutics classification system BCS (biopharmaceutics classification system). They are insoluble in water and can be used in most solvents. Exhibits low solubility, making it low in cosmetic or dermatological preparations and has poor skin absorption and low bioavailability

Method used

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  • Cosmetic or dermatological composition as well as preparation method and application thereof
  • Cosmetic or dermatological composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Compositions in the form of O / W nanoemulsions, comprising the following raw material components in weight percent,

[0079] Asiatic acid 0.5%

[0080] Madecassic acid 0.5%

[0081] Asiaticosides 2%

[0082] Retinol 0.2%

[0083] Eucalyptus essential oil 2%

[0084] Tea Tree Essential Oil 2%

[0085] Rosemary essential oil 1.2%

[0086] Diethylene glycol monoethyl ether (Transcutol) 8%

[0087] 1,2-Pentanediol 2%

[0088] Tween 20 16%

[0089] Polyoxyl 35 castor oil 12%

[0090] The balance is distilled water

[0091] Preparation:

[0092] ① Weigh the eucalyptus essential oil, tea tree oil, rosemary essential oil, diethylene glycol monoethyl ether (Transcutol) and 1,2-pentanediol into container A and mix well.

[0093] ② Take the formulated amount of asiatic acid, madecassic acid, asiaticoside, and retinol, and add them to the mixture in container A and stir until completely dissolved.

[0094] ③ Add distilled water to container B, then add Tween 20 and polyo...

Embodiment 2

[0098] Be the composition of O / W nanoemulsion form, comprise each raw material component of following percentage by weight:

[0099] Ursolic Acid 1%

[0100] Centella Asiatica Extract 1%

[0101] Ginsenosides 1%

[0102] Retinol 0.1%

[0103] Eucalyptus essential oil 2%

[0104] Lemon Essential Oil 1.2%

[0105] Diethylene glycol monoethyl ether (Transcutol) 6%

[0106] 1,2 Pentanediol 2%

[0107] Phenoxyethanol 0.3%

[0108] EDTA-2Na 0.2%

[0109] Sodium Lactate 1%

[0110] Ceramide 0.2%

[0111] Dipotassium Glycyrrhizinate 0.5%

[0112] Poloxamer 188 0.6%

[0113] PEG-8 Caprylic / Capric Glycerides 10%

[0114] Polyoxyl 40 Hydrogenated Castor Oil 12%

[0115] Hydrogenated Lecithin 0.5%

[0116] The balance is distilled water

[0117] Preparation:

[0118] ①Weigh the eucalyptus essential oil, lemon essential oil, diethylene glycol monoethyl ether (Transcutol), and 1,2-pentanediol into container A and mix well.

[0119] ②Take the formulated amount of ursolic acid,...

Embodiment 3

[0124] Be the composition of O / W nanoemulsion form, comprise each raw material component of following percentage by weight:

[0125] Asiatic acid 0.6

[0126] Centella asiaticosides 1.5%

[0127] Oleuropein 1%

[0128] Ginsenosides 2%

[0129] Retinol 0.2%

[0130] Ursolic acid 0.1%

[0131] Eucalyptus Essential Oil 1.2%

[0132] Tea Tree Oil 1.2%

[0133] Lemon essential oil 0.6%

[0134] Dipropylene Glycol 5%

[0135] 1,2 Pentanediol 5%

[0136] Ascorbyl Glucoside 5%

[0137] Phenoxyethanol 0.2%

[0138] EDTA-4Na 0.2%

[0139] Sodium Hyaluronate 1%

[0140] Dipotassium Glycyrrhizinate 0.3%

[0141] Hexapeptide 0.5%

[0142] Sodium Alginate 0.6%

[0143] PEG-6 Caprylic / Capric Glycerides 10%

[0144] Polyoxyl 40 Hydrogenated Castor Oil 8%

[0145] The balance is distilled water

[0146] Preparation:

[0147] ① Weigh the eucalyptus essential oil, tea tree essential oil, lemon essential oil, dipropylene glycol, and 1,2-pentanediol into container A and mix well...

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Abstract

The invention discloses a cosmetic or dermatological composition as well as a preparation method and application thereof, and belongs to medicines and cosmetics. The composition comprises 0.001%-10% of triterpene acid, 0%-10% of triterpenoid saponin, 0%-10% of vitamin A or vitamin A derivatives, 0.1%-20% of terpene-containing essential oil, 1%-40% of an emulsifier, 1%-40% of a co-emulsifier and a proper amount of water and additives. The preparation method comprises the following steps: dissolving the triterpenic acid, the triterpenoid saponin and the vitamin A or the derivatives thereof in the emulsifier, the co-emulsifier and the terpene-containing plant essential oil, performing dispersing in a water phase while stirring, and carrying out high-pressure homogenization. The prepared nano-emulsion is in an oil-in-water type, is excellent in water solubility, clear, transparent, good in stability and high in absorption efficiency, the effects of resisting aging, reducing wrinkles, whitening, inhibiting acnes, inhibiting sebum overflow, inhibiting scar formation, promoting skin wound repair and the like are greatly improved, the preparation method is simple, and the application value of the composition in the fields of medicines and cosmetics is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine and cosmetics, and in particular relates to a cosmetic or dermatological composition and its preparation method and application. Background technique [0002] With age, the activity of skin cell proliferation, collagen synthesis and skin hydration decreases. As a result, the skin looks dull, dry and saggy. With the acceleration of the pace of modern life and the increasing pressure of work, overtime and staying up late, the interference of physical factors and environmental factors, accelerate skin aging and relaxation. [0003] Terpenoids are olefinic compounds whose molecular formula is an integral multiple of isoprene (C5H8), which belong to lipids and are insoluble in water. Terpenes can be classified into monoterpenes, sesquiterpenes, diterpenes, triterpenes, etc. according to the number of isoprene units contained in the molecule. [0004] Triterpenoids are substances composed of several...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/06A61K8/63A61K8/67A61K8/92A61K9/107A61K31/56A61K31/704A61K36/23A61K45/06A61P17/00A61Q19/00A61Q19/02A61Q19/08A61K31/07
CPCA61K8/63A61K8/922A61K8/671A61K8/9789A61K8/068A61Q19/00A61Q19/02A61Q19/08A61K45/06A61K31/56A61K31/704A61K31/07A61K36/23A61K9/1075A61P17/00A61K2800/5922A61K2800/82A61K2800/30A61K2800/782A61K2300/00
Inventor 林振放
Owner 泉州达浔生物科技有限公司
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