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Respiratory syncytial virus recombinant f protein and vaccine composition containing same

A technology of syncytial virus and respiratory tract, applied in the field of fusion protein of recombinant respiratory syncytial virus and its immunogenic composition, which can solve the problems such as difficult to obtain, difficult to purify F protein, and unable to express in large quantities

Pending Publication Date: 2021-08-06
SK BIOSCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This insoluble form of F protein is difficult to purify, does not form the correct protein structure, therefore cannot be expressed in large quantities, and is difficult to act as an antigen capable of inducing an effective immune response in viral defense

Method used

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  • Respiratory syncytial virus recombinant f protein and vaccine composition containing same
  • Respiratory syncytial virus recombinant f protein and vaccine composition containing same
  • Respiratory syncytial virus recombinant f protein and vaccine composition containing same

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Embodiment Construction

[0136] Hereinafter, the embodiments or the like will be described in detail to help understand the invention. However, embodiments in accordance with the present invention may be deformed in various forms, and the scope of the invention should not be construed as limited to the following examples. Embodiments of the invention are provided to those of ordinary skill in the art to explain the present invention more fully.

[0137] 1. Preparation of RSV recombinant F protein

[0138] Preparation of sf protein

[0139] (1) In the present invention, a wild-type RSV was prepared in order to obtain a stable and soluble RSV recombinant F protein. It is well known to those skilled in the art that all of the following mutations are suitable for all RSV subtypes, including wild-type RSV-A2, RSVB and RSV-A long. Hereinafter, mutations were performed with the F protein of the wild-type RSV of the RSV-B gene NO.AEQ 63641.1.

[0140] (2) Remove the transmembrane domain of wild-type F proteins....

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Abstract

The present invention provides a respiratory syncytial virus (RSV) recombinant fusion protein (F protein) in which a polymerization domain derived from a foreign protein is bound to the C terminal of a fusion protein (F protein) lacking a transmembrane domain of a wild-type respiratory syncytial virus (RSV) fusion protein (F protein). The recombinant fusion protein of the present invention is soluble and can retain an F protein trimer. Excellent immune-inducing effects can be expected from the recombinant fusion protein of the present invention, and the vaccine composition containing the same.

Description

Technical field [0001] The present application advocates priority to Korea, filed on November 1, 2018, and all content disclosed in the specification of the application and the appended claims will be included in the present application. The present invention relates to a recombinant respiratory syphilic (RSV) fusion protein (F protein) and an immunogenic composition comprising thereof, in particular, aimed at providing a large number of RSV fusion proteins and inducing specific neutralizing antibodies A recombinant respiratory syncytial virus (RSV) fusion protein (F protein) and its immunogenic composition thereof. Background technique [0002] Respiratory Syncytial Virus, RSV is a very common infectious virus world, which can cause respiratory diseases. In particular, it is the main cause of infant death due to severe respiratory infection. Although infants are the main object of infection, it is well known that it can also cause fatal respiratory diseases by causing respirator...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/005A61K39/155A61P31/14A61K39/00
CPCC07K14/005A61P31/14C12N2760/18534C12N2760/18522C12N2795/10122C12N2710/14143A61K39/12A61K39/0275A61K2039/70A61K2039/6075A61K2039/55505Y02A50/30C07K2319/00C07K2319/70C07K14/255A61K39/155A61K2039/5256C12N2795/10111A61K39/00C07K2319/735C12N2760/18571
Inventor 金恩顺权泰佑徐基元洪承惠李受陈咸东洙金勋
Owner SK BIOSCI CO LTD
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