Liquid storage and controlled release assembly and microfluidic detection chip

A liquid storage and detection chip technology, used in semiconductor/solid-state device parts, optical components, engine components, etc., can solve the problems of inability to release multiple reagents separately, single sample processing, and instability.

Pending Publication Date: 2021-07-23
NANJING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is unstable, and it is impossible to release multiple reagents at different times
These shortcomings prevent the chip from integrating more reaction processes and simplifying sample processing.
This is not conducive to the development of microfluidic detection chip technology products in the direction of miniaturization, functional integration, and easy operation.
Moreover, the storage of liquid reagents cannot guarantee the release of all liquids, and there are liquid residues
Driven by centrifugal force, various reagents in the microfluidic detection chip are released, and the remaining reagents may flow out in subsequent centrifugation, thus affecting the accuracy of subsequent detection

Method used

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  • Liquid storage and controlled release assembly and microfluidic detection chip
  • Liquid storage and controlled release assembly and microfluidic detection chip
  • Liquid storage and controlled release assembly and microfluidic detection chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Figure 10 It is a cross-sectional view when the liquid storage and controlled release assembly is installed in the "liquid storage and controlled release assembly installation chamber". At this time, the metal ring and the heat-conducting metal block in the metal ring paraffin valve are not integral structures. The substrate structure under the metal ring paraffin valve is a porous structure, and a heating device is connected to the structure for heating and melting the paraffin. The reagents are pre-packaged in the bottle structure, and the middle of the metal ring is sealed with paraffin. Below the metal ring is a plane heating device. The metal ring is closely connected with the mouth of the liquid flow pipeline of the substrate. After heating by the heating device, the solid paraffin melts, and the reagent is separated from the bottle structure by centrifugal force, and enters the liquid flow pipeline through the metal ring paraffin valve.

[0035] Figure 11 It...

Embodiment 2

[0037] Figure 12It is a sectional view when the liquid storage and controlled release component is installed in the "liquid storage and controlled release component installation cavity" (the metal ring and the heat-conducting metal block are not set as an integral structure, and the circuit board is set below), at this time the metal ring is paraffin The metal ring in the valve is not integrated with the heat-conducting metal block. The substrate structure under the metal ring paraffin valve is a porous structure, and a heating device is connected to the structure for heating and melting the paraffin. The heating device is connected to the lower circuit board, and the heating device is controlled to start through the circuit system. The passive board is essentially a circuit board, and through reasonable wiring, heating devices are welded at the hole-like or hole-like structures below the installation cavities of the substrate liquid storage and controlled release components....

Embodiment 3

[0039] Figure 14 It is a cross-sectional view of the metal ring paraffin valve after the overall package (the metal ring and the heat conduction metal block are set as an integrated structure). At this time, the metal ring and the heat conduction metal block in the metal ring paraffin valve are set as an integral structure. At this time, the heat-conducting raised part of the metal ring can be stuck at the lower structure to play a role of positioning and fixing. And the raised part of the metal ring is close to the lower structure. The substrate structure under the metal ring paraffin valve is a hole-like or hole-like structure, and a heating device is connected to the structure for heating and melting the paraffin. The heating unit is connected to the passive plate below. The heating device is set as a heating resistor. In order to further improve the heating effect, a heat-conducting metal sheet is added above the heating resistor. The heat-conducting metal sheet and th...

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Abstract

The invention provides a liquid reagent storage and controlled release device. The liquid reagent storage and controlled release device is used for realizing timed and controllable release after liquid storage, has no liquid residue and reduces the influence of the residual reagents on the subsequent detection accuracy. In order to achieve the purpose, the disclosed liquid storage and controlled release assembly comprises a liquid storage device and a metal ring paraffin valve, wherein the metal ring paraffin valve is composed of a metal ring and paraffin filled in the metal ring, an opening of the liquid storage device matches with the outer diameter of the metal ring, the opening of the liquid storage device is blocked by the metal ring paraffin valve, the liquid storage device is of a bottle-shaped structure, and the metal ring is of a cylindrical hollow annular structure.

Description

technical field [0001] The invention relates to the field of microfluidic detection chips, in particular to liquid storage and controlled release devices in the microfluidic detection chip, and related microfluidic detection chips. Background technique [0002] With the improvement of medical technology, the demand for medical equipment has become more and more diverse. Under such conditions, medical equipment based on microfluidic technology is also continuously developed and put into use, among which timely diagnostic equipment (POCT) is particularly prominent. Centrifugal force microfluidics plays an important role in POCT, and its main advantages are the modular setup of the system and disposable, easily replaceable microfluidic detection chips, as well as many existing unit operations, which make liquid handling very accurate. The reaction process of the sample is realized in the chip, which makes the pre-storage of reagents a key factor in the use of the chip. [00...

Claims

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Application Information

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IPC IPC(8): F16K99/00B81B7/02
CPCF16K99/003F16K99/0032F16K99/0044F16K99/0063F16K2099/0084
Inventor 王光辉刘国桢张畅斌张雅
Owner NANJING UNIV
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