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A kind of oromucosal drug delivery system

A technology of drug delivery system and oral mucosa, applied in the field of medicine, can solve the problems of Parkinson's disease patients, sputum infection in the upper respiratory tract, impaired motor function, etc., and achieves the best therapeutic effect, constant blood drug concentration, and good curative effect.

Active Publication Date: 2021-08-31
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the "switch" fluctuations in the treatment of Parkinson's disease within 5 to 30 minutes, the marketed drugs include levodopa inhalation, subcutaneous injection of apomorphine and apomorphine sublingual film. Levodopa often causes side effects such as cough, nausea, upper respiratory tract infection, and sputum discoloration; clinical data on apomorphine sublingual film found that sublingual administration of apomorphine caused stomatitis, nausea, vomiting, etc.; and due to impaired motor function, Subcutaneous apomorphine is difficult for Parkinson's patients

Method used

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  • A kind of oromucosal drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A1

[0063] 0.25g of rotigotine is mixed with 0.53g of fused glyceryl monostearate as lipid and 0.23g of lecithin as emulsifier, melted at 80°C, and the melted mixture is made into colostrum through a high-pressure milk homogenizer, Homogenize 4 times under 120MPa high pressure, cool and dry to obtain coated particles with an average particle size of 578nm.

Embodiment A2

[0065] Mix 0.28g of rotigotine with 0.54g of molten diglyceride behenate as a lipid and 0.18g of sodium taurocholate as an emulsifier, melt at 75°C, and pass the molten mixture through a high-pressure homogenization mechanism into colostrum, homogenized 4 times under 110MPa high pressure, and cooled to obtain wrapped particles with an average particle size of 456nm.

Embodiment A3

[0067] Mix 0.2g of rotigotine with 0.64g of molten glyceryl citrate as lipid and 0.16g of sodium lauryl sulfate as emulsifier, melt at 85°C, and pass the molten mixture through a high-pressure homogenizer to prepare The colostrum is homogenized 4 times under 130MPa high pressure, cooled and dried to obtain coated particles with an average particle size of 632nm.

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Abstract

The invention relates to the field of medicine, in particular to an oral mucosa drug delivery system. The oromucosal drug delivery system comprises a matrix and inclusion particles dispersed in the matrix, the inclusion particles include drug A and an inclusion material encapsulating the drug A; the inclusion particles contain lipids, so The lipid accounts for 60-100 wt% of the weight of the inclusion material; the matrix optionally further contains drug B, which is the same as or different from the drug A. The drug release of the oral mucosa drug delivery system of the present invention can be more stable, avoid side effects caused by concentration fluctuations, and can last for a longer period of time.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an oral mucosa drug delivery system. Background technique [0002] Parkinson's disease (Parkinson's disease) is a common middle-aged and elderly nervous system degenerative disease, mainly characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and pathological changes in the formation of Lewy bodies, decreased dopamine transmitters in the striatum, Biochemical changes in the imbalance of dopamine and acetylcholine transmitters, tremors, muscle rigidity, slow movement, postural balance disturbance motor symptoms and hyposmia, constipation, sleep behavior abnormalities and depression and other non-motor symptoms are clinically significant features. [0003] The cause of Parkinson's disease is still unclear, but it is generally believed to be related to genetic and environmental factors. People with Parkinson's disease family members are more likely to get...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K45/06A61K47/14A61K47/24A61K47/28A61K47/22A61K47/34A61K47/38A61P25/16A61K9/08A61K9/20A61K9/50
CPCA61K9/0056A61K9/006A61K9/08A61K9/2054A61K9/5015A61K9/7007A61K45/06A61K47/34A61K47/38A61P25/16
Inventor 全丹毅徐文婷
Owner 江苏集萃新型药物制剂技术研究所有限公司
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