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Anti-infection coating capable of realizing immediate construction in operation as well as preparation method and application of anti-infection coating

An anti-infection and coating technology, which is applied in coatings, pharmaceutical formulations, medical science, etc., can solve problems such as adjusting the content of anti-infection functional components, and achieve improved biocompatibility, wide application prospects, and good biocompatibility Effect

Active Publication Date: 2021-07-20
中国人民解放军总医院第八医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, many antibacterial bone tissue implants disclosed in the prior art need to be prepared in advance before the operation, and the content of the anti-infective functional components in the implant cannot be adjusted according to the degree of infection at the lesion during the operation

Method used

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  • Anti-infection coating capable of realizing immediate construction in operation as well as preparation method and application of anti-infection coating
  • Anti-infection coating capable of realizing immediate construction in operation as well as preparation method and application of anti-infection coating
  • Anti-infection coating capable of realizing immediate construction in operation as well as preparation method and application of anti-infection coating

Examples

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Effect test

Embodiment 1

[0063] This embodiment provides a bone tissue implant, including a TCP porous artificial bone matrix structure (average pore size 100 μm, porosity 68%) and an anti-infection coating covering its surface that can realize immediate construction during surgery; The anti-infection coating includes an anti-infection drug coating (isoniazid, rifampicin, osteogenic growth peptide) on the surface of the matrix structure and a polymer material coating (chitosan) on the surface of the anti-infection drug coating. sugar (number average molecular weight 300kDa) and β-sodium glycerophosphate). Its preparation method is as follows:

[0064] (1) Place the TCP porous artificial bone matrix structure in an aqueous solution containing isoniazid (8%), rifampicin (4%), and osteogenic growth peptide (0.07%), and carry out vacuum adsorption under a negative pressure of 0.1MPa , until no air bubbles are generated around the artificial bone, and the surface of the TCP porous artificial bone matrix s...

Embodiment 2

[0067] This embodiment provides a bone tissue implant, comprising a TCP porous artificial bone matrix structure (average pore diameter 120 μm, porosity 75%) and an anti-infection coating covering its surface that can realize immediate construction during surgery; The anti-infection coating comprises an anti-infection drug coating (levofloxacin, osteogenic growth peptide) coated on the surface of the matrix structure and a polymer material coating (chitosan (number-average molecular weight 400kDa) coated on the surface of the anti-infection drug coating ) and β-sodium glycerophosphate). Its preparation method is as follows:

[0068] (1) Place the TCP porous artificial bone matrix structure in an aqueous solution containing levofloxacin (10%) and osteogenic growth peptide (0.07%), and carry out vacuum adsorption under a negative pressure of 0.2 MPa until no bubbles are generated around the artificial bone, and the TCP The surface of the porous artificial bone matrix structure i...

Embodiment 3

[0071] This embodiment provides a bone tissue implant, including New Zealand rabbit autologous ilium bone matrix structure (average pore diameter 80 μm, porosity 65%) and an anti-infection coating covering its surface that can realize immediate construction during surgery; The anti-infection coating includes an anti-infection drug coating (isoniazid, rifampicin, osteogenic growth peptide) coated on the surface of the matrix structure and a polymer material coating ( Chitosan (number average molecular weight 300kDa) and β-sodium glycerophosphate). Its preparation method is as follows:

[0072] (1) The New Zealand rabbit autologous ilium bone matrix structure was placed in an aqueous solution containing isoniazid (8%), rifampicin (4%), and osteogenic growth peptide (0.07%), under a negative pressure of 0.1MPa. Vacuum adsorption until no air bubbles are generated around the matrix structure, and anti-infective drug coating is obtained on the surface of the autologous ilium bone ...

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Abstract

The invention relates to an anti-infection coating capable of realizing immediate construction in an operation as well as a preparation method and application of the anti-infection coating. The anti-infection coating comprises an anti-infection drug coating covering the surface of a main body structure and a high polymer material coating covering the surface of the anti-infection drug coating, and the high polymer material comprises chitosan and beta-sodium glycerophosphate. The temperature-sensitive phase-change high polymer material coating can be subjected to rapid phase change under a heating condition, and the surface of the main body structure is covered with an anti-infection drug, so that immediate construction in an operation is realized, the defect that in the prior art, an antibacterial coating needs to be prepared before the operation, and then the storage problem needs to be considered is overcome. Meanwhile, the content of the anti-infection drug can be adjusted according to the infection degree of the focus in the operation, and personalized treatment is achieved. Meanwhile, the biocompatibility of the anti-infection coating is good, the local slow release behavior of the anti-infection drug can be achieved, and the action time of the drug is remarkably prolonged.

Description

technical field [0001] The invention belongs to the technical field of bone implant materials, and in particular relates to an anti-infection coating which can realize immediate construction during operation and its preparation method and application, especially relates to an anti-infection coating capable of preventing and / or treating tuberculosis infection or postoperative non-specific An anti-infection coating that can be immediately constructed during an infection operation and a preparation method and application thereof. Background technique [0002] The treatment of bone infectious diseases is a major clinical challenge, especially the infection caused by Mycobacterium tuberculosis. Because its treatment requires the continuous use of antibiotics, it may even require debridement and reconstructive surgery. Biofilm around implants, immune evasion of pathogenic bacteria, and drug resistance are all factors that lead to failure of bone tissue infection treatment. In re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/12A61L27/22
CPCA61L27/34A61L27/54A61L27/227A61L27/12A61L2300/404A61L2300/602A61L2300/252A61L2430/02A61L2420/08A61L2400/18C08L5/08
Inventor 崔旭李渊李力韬
Owner 中国人民解放军总医院第八医学中心
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