Ex vivo organ treatment with peg-phospholipid molecules
A PEG-, phospholipid technology, applied in application, preservation of human or animal body, urinary tract/kidney cells, etc., can solve problems such as hemodynamic instability, delayed graft function, impaired graft perfusion, etc.
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[0037] The present invention relates generally to isolated organ treatments, and in particular to such isolated organ treatments capable of treating, inhibiting or preventing thrombotic inflammation (which precedes activation of the adaptive immune system) and hypotension induced by organ reperfusion.
[0038] The ex vivo methods of the present invention result in significant improvements in organ transplantation and organ handling by protectively shielding or coating the endothelial intima or endothelium and parenchyma of the vasculature of such organs or parts of such organs. This protective coating helps effectively protect against thrombotic inflammation as well as the deleterious effects of ischemia-reperfusion (I / R) injury (IRI).
[0039] The glycocalyx is essential to ensure microvascular hemostasis and prevent thrombotic inflammation. However, this glycocalyx is very sensitive to oxidative stress and ischemia-induced damage. Thus, during ischemia that occurs in associ...
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