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Laxative tablet

A technology for tablets and laxatives, which is applied in the directions of pill delivery, medical preparations of inactive ingredients, and drug combinations, etc., can solve the problems of water suspension being difficult to pass through nutrition tubes, etc., and achieves the advantages of short disintegration time and reducing the burden of taking. Effect

Active Publication Date: 2021-06-22
SETOLAS HLDG INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aqueous suspension of magnesium oxide tablets manufactured by the previous formula is difficult to pass through the 3Fr tube nutrition tube smoothly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] According to the formulation in Table 1, tablets for laxatives were produced by the following production method. In addition, in Tables 1-6, "internal additive" means the reagent used at the time of producing a granule, and "external additive" means the reagent further mixed with the granule obtained beforehand. In Tables 1 to 6, the expression "mg" represents the relative amount of each component when magnesium oxide is 100.0 mg.

[0112] Magnesium oxide with a volume basis 50% particle diameter (D50) of 6.5 μm: 1500 g, crystalline cellulose: 168 g, croscarmellose sodium: 58.5 g, volume basis 50% particle diameter ( D50) is 5.4 μm insoluble polyvinylpyrrolidone 1:12g mixed, and then granulated by a roll-forming dry granulator at a roll pressure of 5 MPa. The granulated matter is pulverized by an oscillating pulverizer to produce granulated matter. Calcium stearate: 16 g, crystalline cellulose: 34.6 g, aspartame: 1.3 g, and sulfame potassium acetate: 2.7 g were added ...

Embodiment 2

[0114] According to the formula of Table 1, the laxative tablet is manufactured. In Example 1, the addition amount of croscarmellose sodium was changed to 52.5g, and the addition amount of insoluble polyvinylpyrrolidone 1 was changed to 18g, except that tablets were produced in the same way, and the weight per tablet was obtained. 120mg, 6mm in diameter, 3.4mm in thickness magnesium oxide tablet. Table 7 shows the volume-based 50% particle size (D50), volume-based 90% particle size (D90), disintegration time, and tube permeability test results of the obtained magnesium oxide tablet after suspension in water.

Embodiment 3

[0116] According to the formula of Table 1, the laxative tablet is manufactured. In Example 1, the addition amount of croscarmellose sodium was changed to 43.5g, and the addition amount of insoluble polyvinylpyrrolidone 1 was changed to 27g, except that tablets were produced in the same manner, and the weight per tablet was obtained. 120mg, 6mm in diameter, 3.4mm in thickness magnesium oxide tablet. Table 7 shows the volume-based 50% particle size (D50), volume-based 90% particle size (D90), disintegration time, and tube permeability test results of the obtained magnesium oxide tablet after suspension in water.

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Abstract

Provided is a laxative tablet which includes magnesium oxide as a main constituent, wherein (1) the particle size by volume of 50% (D50) of particles which emerge when the tablet is suspended in water is 70 mum or less as determined by laser diffractometry, (2) the particle size by volume of 90% (D90) of the particles which emerge when the tablet is suspended in water is 130 mum or less as determined by laser diffractometry, and (3) the dissolution time of the tablet when the tablet is suspended in water according to the Japanese Pharmacopoeia - general testing methods - dissolution testing methods is 10 seconds or less.

Description

technical field [0001] The present invention relates to a laxative tablet mainly composed of magnesium oxide. More specifically, it relates to a laxative tablet which has a fine particle size and which disintegrates in a short time when the tablet is suspended in water, and a method for producing the same. Background technique [0002] Conventionally, tablets containing magnesium oxide as a main component have been widely known as tablets for antacids and laxatives, and are now widely used. The magnesia-containing tablet is produced by blending additives such as a binder and a disintegrating agent with magnesia and performing tablet compression. [0003] The present applicant proposes an antacid / laxative tablet, which has a high magnesium oxide content, a short disintegration time, and basically no tableting failure, blackening, and tableting spots (Patent Document 1). The tablet described in Patent Document 1 is characterized in that the content ratio of magnesium oxide h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/10A61K9/20A61K47/32A61K47/38A61K33/08
CPCA61K33/08A61P1/10A61K9/2054A61K9/2027A61K9/0095A61K9/20A61K47/38A61K47/32A61K9/2077A61K9/2095
Inventor 服部笃之
Owner SETOLAS HLDG INC
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