Application of ervophenol in preparation of anti-candida albicans drugs

Abstract

The invention relates to an application of ervophenol in preparation of an anti-candida albicans drug. The invention particularly discloses the application of ervophenol in preparation of antifungal drugs, and fungi comprise candida albicans. Experiments prove that the ervophenol has a remarkable inhibition effect on the growth of the candida albicans, and also has a good inhibition effect on the adhesion, hypha formation, biofilm formation and toxicity of the candida albicans, so that the effect of the ervophenol on resisting candida albicans strains does not mainly depend on killing the candida albicans, and the infection ability and pathogenicity of the candida albicans are mainly inhibited by inhibiting the adhesion, hypha formation, biofilm formation and toxicity of the candida albicans. Therefore, when the ervophenol is used for treating infectious diseases caused by the candida albicans, drug resistance is not easy to generate. In conclusion, the ervophenol has a good application prospect in the development of novel antifungal drugs, especially in the preparation of drugs for preventing and / or treating Candida albicans infection.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of efferofol in the preparation of antifungal drugs, especially anti-Candida albicans drugs. Background technique [0002] Candida is the most common opportunistic pathogen in fungi, also known as Candida. It often parasitizes on human skin, oral cavity, vagina and intestinal mucosa, etc. When the body's immune function is low or the micro-ecological environment of the normal habitat is out of balance, it is easy to cause candida infectious diseases. Candida can cause superficial skin and mucous membrane or systemic infection, and different parts of the infection can cause different diseases, including skin candidiasis, candidal stomatitis, vaginitis, cystitis, pyelonephritis, meningitis, and bacteremia And biliary tract infection etc., in a word, candida infectious disease is very harmful to human life. [0003] Clinically common Candida mainly ...

AI Technical Summary

Problems solved by technology

However, fluconazole plays a bacteriostatic role mainly by inhibiting fungal replication. It is clinically found that in AIDS patients with oral candida infection, the fungus is not completely cleared and often recurs. Long-term repeated treatment is also due to resistance. Emergence of drug-resistant strain leads to increased clinical treatment failure in HIV

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