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Application of flos daturae in cooperation with pentobarbital sodium in preparation of medicine for improving sleep

A technique for pentobarbital sodium and sleep improvement, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as difficulty in drug withdrawal, obvious side effects, and dependence on sleeping pills, so as to improve sleep rate, prolong sleep time, The effect of shortening sleep latency

Inactive Publication Date: 2021-06-11
JIANGHAN UNIVERSITY
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Problems solved by technology

[0002] Long-term insomnia has a significant impact on the quality of life, functional ability and health status of patients. At present, the most widely used drugs for the treatment of insomnia are benzodiazepines, which are clinically proven to be effective, but they also have obvious side effects. Long-term use Sleeping pills may cause some dependence and make withdrawal difficult

Method used

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  • Application of flos daturae in cooperation with pentobarbital sodium in preparation of medicine for improving sleep
  • Application of flos daturae in cooperation with pentobarbital sodium in preparation of medicine for improving sleep
  • Application of flos daturae in cooperation with pentobarbital sodium in preparation of medicine for improving sleep

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Embodiment 1

[0019] The present embodiment verifies the synergistic effect of Dajinhua and pentobarbital sodium by mouse experiments, specifically as follows:

[0020] 1. Materials and methods

[0021] (1) Experimental animals

[0022] Adult male Kunming mice, weighing 20±3g, were provided by the Animal Experiment Center of China Three Gorges University, certificate number: SYXK(E)2017-0061. The mice were kept in a well-ventilated animal laboratory with 12h / 12h alternation of light and dark, an ambient temperature of (22±2)°C, and a relative humidity of (55±5)%. The mice had free access to food and water, and were acclimated to the environment for at least 7 days before the experiment.

[0023] (2) Drugs: Yangjinhua was purchased from Wuhan Traditional Chinese Medicine Store; Pentobarbital Sodium was purchased from Jingdu Biomedical Technology Co., Ltd. (Shanghai); Estazolam Tablets were purchased from Shandong Xinyi Pharmaceutical Co., Ltd. H37023047, specification: 1mg / tablet.

[002...

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Abstract

The invention discloses application of flos daturae in cooperation with pentobarbital sodium in preparation of a medicine for improving sleep, and belongs to the technical field of medicine products, and the mass ratio of flos daturae to pentobarbital sodium is 1: 1 or 1: 16.5-32.5. Mouse experiment research finds that the flos daturae has an effect of inhibiting autonomous activity of mice but does not have a direct sleep effect when being independently used, but synergistic effects of the flos daturae and the pentobarbital sodium of the subthreshold dosage and the pentobarbital sodium of the suprathreshold dosage find that the flos daturae and the pentobarbital sodium of the subthreshold dosage can significantly improve the sleep rate of the mice; meanwhile, the flos daturae and the pentobarbital sodium in a suprathreshold dose can remarkably shorten the sleep latency period of the mouse and prolong the sleep time, namely, the flos daturae and the pentobarbital sodium generate a synergistic effect, can inhibit a central nervous system and have sedative and hypnotic effects, so that the flos daturae and the pentobarbital sodium can be used for preparing the medicine for improving the sleep, have no obvious side effects and are suitable for clinical application. Wide application prospects are realized.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical products, and in particular relates to the application of Yangjinhua and pentobarbital sodium in the preparation of sleep-improving medicines. Background technique [0002] Long-term insomnia has a significant impact on the quality of life, functional ability and health status of patients. At present, the most widely used drugs for the treatment of insomnia are benzodiazepines, which are clinically proven to be effective, but they also have obvious side effects. Long-term use Sleeping pills may create a certain degree of dependence, making withdrawal difficult. Therefore, finding new sedative-hypnotic drugs with less side effects and better curative effect is the focus and difficulty of research. [0003] Daturae Flos (Daturae Flos) belongs to the genus Daturae metel L. of the family Solanaceae. According to modern pharmacological studies, scopolamine and atropine contained in Dajinhua ha...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P25/20A61K31/515
CPCA61K36/81A61K31/515A61P25/20
Inventor 李长雷马宝苗易卉玲陈晓青熊哲
Owner JIANGHAN UNIVERSITY
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