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Purpose of fructus bruceae oil emulsion in medicine preparation

A javanica javanica oil and a technology for preparing medicines, which are applied in the field of medicine and can solve the problems of no specific medicines for oral ulcers

Active Publication Date: 2021-06-08
沈阳药大雷允上药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, there is currently no specific drug that can completely eradicate oral ulcers.

Method used

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  • Purpose of fructus bruceae oil emulsion in medicine preparation
  • Purpose of fructus bruceae oil emulsion in medicine preparation
  • Purpose of fructus bruceae oil emulsion in medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription and preparation technology of javanica javanica oil oral emulsion

[0028] prescription

[0029] Brucea javanica oil 100mL

[0030] Soy Lecithin 15g

[0031] Glycerin 25mL

[0032] Add water for injection to 1000mL

[0033] Preparation Process

[0034] Preparation of javanica oil:

[0035] After pulverizing 800g of Brucea javanica medicinal material with a pulverizer, soak 200kg of petroleum ether in the extraction tank at 25°C for 24 hours; the soaking liquid flows into the distillation tank, and the petroleum ether is distilled at 60°C; the distilled petroleum ether is condensed by the condenser and returned to the extraction tank. Soak the pulverized medicinal materials in the distillation tank, and extract them repeatedly 4 times. The time for each distilled petroleum ether to return to the extraction tank to soak the medicinal materials is 30 minutes; -0.01MPa, recovered by distillation under reduced pressure at 80°C. When there is no distillate,...

Embodiment 2

[0039] The effect of the javanica javanica oil oral emulsion obtained in embodiment 1 on the ulcer number and area of ​​recurrent oral ulcer rats.

[0040] Material

[0041] SPF grade male SD rats, 32, body weight 220 ~ 300g, purchased from Changchun Changsheng Biotechnology Co., Ltd.; oral emulsion of javanica javanica oil obtained in Example 1.

[0042] method

[0043]32 SD rats were randomly divided into 4 experimental groups, namely: model group, low dose group, middle dose group and high dose group, with 8 rats in each group. Both sides of the spine of all rats were shaved and disinfected, and 0.1 mL of complete Freund's adjuvant was injected intradermally on both sides, once a week, for a total of three injections. After the injection, the incidence of oral ulcers in the rats was observed, and it was found that on the 7th day after the injection, all the rats had symptoms of oral ulcers. Then on the 8th day, except the model group, other groups were all given oral emu...

Embodiment 3

[0052] The prophylactic effect of the javanica javanica oil oral emulsion obtained in Example 1 on ulcers in recurrent oral ulcer rats.

[0053] Material

[0054] SPF grade male SD rats, 32, weighing 220-300 g, provided by Changchun Changsheng Biotechnology Co., Ltd., oral emulsion of javanica javanica oil obtained in Example 1.

[0055] method

[0056] 32 SD rats were randomly divided into 4 experimental groups, namely: model group, low dose group, middle dose group and high dose group, with 8 rats in each group. Both sides of the spine of all rats were shaved and disinfected, and 0.1 mL of complete Freund's adjuvant was injected intradermally on both sides, once a week, for a total of three injections. On the first day of injection of complete Freund's adjuvant, except the model group, other groups were given oral emulsion of javanica javanica oil for intragastric administration, respectively according to 50mg / kg, 100mg / kg, 200mg / kg of three doses of javanica javanica. Or...

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Abstract

The invention puts forwards a purpose of a fructus bruceae oil emulsion in medicine preparation. The medicine is used for treating or preventing dental ulcers, and especially has an obvious effect in treatment or prevention of recurrent oral ulcers.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to the application of javanica javanica oil emulsion in the preparation of medicine. Background technique [0002] Brucea javanica is the dry mature fruit of Brucea javanica (L.) Merr, a plant of the genus Brucea javanica in the family Bitterwoodaceae. Harvest when the fruit is ripe in autumn, remove impurities and dry in the sun. Brucea javanica was first recorded in "Supplements to Compendium of Materia Medica" written by Zhao Xuemin in the Qing Dynasty. The efficacy recorded in the Pharmacopoeia of the People's Republic of China is clearing away heat and detoxifying, cutting off malaria, stopping diarrhea, and corroding superfluous skin. For diseases, malaria; external treatment of superfluous, corns. As early as the 1950s, it was reported that javanica javanica oil had certain curative effect on papilloma of external auditory canal and laryngeal papilloma. In t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/107A61P1/02
CPCA61K36/185A61K9/107A61P1/02Y02A50/30
Inventor 李薇周浩罗岩纪圣君
Owner 沈阳药大雷允上药业有限责任公司
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