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Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof

A nano-composite, mitochondrial technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of uncertain plant extract components and their contents, poor stability of plant extract components, single anti-aging active components, etc. It can restore mitochondrial energy, increase ATP production, and prolong cell life.

Active Publication Date: 2021-06-04
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many types of anti-aging cosmetics on the market, there are still the following problems: (1) plant extracts are often added in anti-aging cosmetics, but it is difficult to ensure stability and effectiveness. First, the plant extracts themselves have poor stability and are easy to decompose ; The second is that the effective substances and contents of plant extracts are not certain, and the mechanism of action is unknown; (2) The anti-aging active ingredients of anti-aging cosmetics are single or the target is single, which greatly reduces the anti-aging effect; (3) Anti-aging active substances Most of them have poor stability and are sensitive to light and heat. They are easily inactivated or oxidatively degraded after being directly added to skin care products for a period of time, which not only reduces the efficacy of skin care products but also causes skin irritation; (4) due to the skin's own barrier function , it is difficult for anti-aging active substances to penetrate the stratum corneum to reach the deep structure of the skin to play a role, and the bioavailability is low, resulting in poor anti-aging effect

Method used

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  • Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof
  • Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof
  • Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof

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preparation example Construction

[0082] The present invention also provides a preparation method of the mitochondria-targeted skin anti-aging nano composition described in the above technical solution, comprising the following steps:

[0083] Mixing liquid lipids, cell penetration enhancers, emulsifiers, co-emulsifiers and other water-insoluble anti-aging active ingredients to obtain an oil phase;

[0084] mixing NMN and other water-soluble anti-aging active ingredients with water to obtain an aqueous phase;

[0085] Mixing the oil phase and the water phase to emulsify and then micronize to obtain a micron-sized dispersion;

[0086] The micron-scale dispersion is subjected to nano-processing to obtain the anti-aging nano composition targeting mitochondria.

[0087] The preparation method provided by the present invention is divided into water-soluble anti-aging active ingredients and water-insoluble anti-aging active ingredients according to the water solubility of other anti-aging active ingredients, and di...

Embodiment 1

[0101] 5% isopropyl myristate, 0.1% retinol, 6% adenosine, 0.5% polyquaternium-51, 3% macrogol caprylate, 3% soybean lecithin, 5% Diethylene glycol monoethyl ether is mixed, heated and dissolved in a water bath at 35°C to obtain an oil phase;

[0102]Add 10% NMN, 0.1% vitamin P, 0.05% copper peptide, 0.05% palmitoyl hexapeptide-12, and 10% trehalose into 57.2% purified water, heat and dissolve in a water bath at 35°C to obtain an aqueous phase;

[0103] After the oil phase and the water phase are obtained, add the water phase to the oil phase dropwise at a rate of 4 drops / second under the condition of heating in a water bath at 35°C. During the dropping process, the stirring rate is controlled at 500rpm. Under high-speed shear emulsification for 8 minutes under high-speed conditions, a micron-sized dispersion was obtained;

[0104] The micron-scale dispersion was subjected to high-pressure homogenization treatment at a temperature of 35° C. and a pressure of 500 bar, circulat...

Embodiment 2

[0107] 1% squalene, 5% hydroxypinacolone retinoate, 3% fatty acid, 0.1% dipalmitoylphosphatidylcholine, 1% polyglycerol-10 laurate, 0.5% hydroxylated lecithin, 1 Mix %PPG-26-butanol-26, heat and dissolve in a water bath at 55°C to obtain an oil phase;

[0108] Add 0.1% NMN, 5% tea polyphenols, 5% carnosine, 0.5% acetyl tetrapeptide-9, 0.5% palmitoyl pentapeptide-4, 5% ectoine, 5% β-glucan to 67.3 % in purified water, heated and dissolved in a water bath at 55°C to obtain an aqueous phase;

[0109] After the oil phase and the water phase are obtained, add the water phase to the oil phase dropwise at a rate of 2 drops / second under the condition of heating in a water bath at 55°C. During the dropping process, the stirring rate is controlled at 600rpm. Under high-speed shear emulsification for 7 minutes under high-speed conditions, a micron-sized dispersion was obtained;

[0110] The micron-sized dispersion was subjected to high-pressure homogenization treatment at a temperature...

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Abstract

The invention relates to the field of cosmetics, in particular to a targeted mitochondrial skin anti-aging nano composition. The nano composition comprises beta-nicotinamide mononucleotide NMN, other anti-aging active ingredients and a nano drug carrier; the NMN accounts for 0.1-10% of the total mass of the nano composition; the other anti-aging active ingredients comprise at least one of an antioxidant, a protein synthesis accelerant, an anti-photoaging agent and a humectant; and the nano drug carrier comprises the following raw materials: a cell penetration promoting agent, an emulsifier, a co-emulsifier, liquid lipid and water. The anti-aging active ingredients of different mechanisms are reasonably matched and have a synergistic effect; the anti-aging active ingredients are wrapped by the nano drug carrier, so that the stability of the anti-aging ingredients is improved; and the active ingredients efficiently enter deep skin tissues and anti-aging target cells and mitochondria, so that tissue and cell dual targeting is realized, the bioavailability is improved, the anti-aging effect is improved, and the composition is mild and non-irritant to skin and can be widely applied to cosmetics.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a mitochondrial-targeted skin anti-aging nano composition and its preparation method and application. Background technique [0002] Skin aging refers to the decline of the skin's ability to protect and regulate the body, the skin cannot adapt to changes in the internal and external environment, and there are changes in the overall appearance of the skin, such as color, luster, shape, and texture. Skin aging is a natural phenomenon in the process of life. Although it is unstoppable, some methods can be used to slow down the pace of aging. Anti-aging cosmetics are such a class of cosmetics aimed at delaying skin aging. [0003] Although there are many types of anti-aging cosmetics on the market, there are still the following problems: (1) plant extracts are often added in anti-aging cosmetics, but it is difficult to ensure stability and effectiveness. First, the plant extracts t...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/06A61Q19/08A61Q19/00
CPCA61K8/606A61K8/068A61Q19/08A61Q19/00A61K2800/21
Inventor 刘卫陈家玲王曦沈慧慧吴雨桐吕赛龙
Owner WUHAN BEST CARRIER NANO TECH
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