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Houttuynia cordata volatile oil heart-protecting capsule for reducing toxicity and enhancing efficacy in chemotherapy and preparation method thereof

A technology of Houttuynia cordata and volatile oil, applied in the directions of capsule delivery, medical preparations containing active ingredients, applications, etc., can solve problems such as restricted use, toxic reactions, serious heart problems, etc., achieve myocardial damage prevention and repair, improve appetite, improve The effect of immunity

Inactive Publication Date: 2021-06-01
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anthracycline antibiotics (such as doxorubicin) are typical representatives of these drugs. As a highly effective broad-spectrum anti-tumor antibiotic, the curative effect is confirmed, but severe cardiotoxicity in clinical chemotherapy presents a significant dose- The effect is linear, which greatly limits its use

Method used

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  • Houttuynia cordata volatile oil heart-protecting capsule for reducing toxicity and enhancing efficacy in chemotherapy and preparation method thereof
  • Houttuynia cordata volatile oil heart-protecting capsule for reducing toxicity and enhancing efficacy in chemotherapy and preparation method thereof
  • Houttuynia cordata volatile oil heart-protecting capsule for reducing toxicity and enhancing efficacy in chemotherapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Myocardial protective effect of Houttuynia cordata volatile oil

[0023] 1. Experimental materials

[0024] 1.1 Materials and reagents

[0025] The volatile oil of Houttuynia cordata was obtained by the following method: referring to the 2010 edition of Chinese Pharmacopoeia, Appendix I, XD volatile oil determination method (method A) to extract the volatile oil: Houttuynia cordata was crushed into coarse powder by a pulverizer, soaked in distilled water for 10 h at room temperature, and the ratio of solid to liquid 1:10, heated to reflux for 10 h to obtain the Houttuynia volatile oil. The main components of the volatile oil identified by GC-MS chemical composition were capric acid (35.63%), palmitic acid (22.64%), methyl nonanone (10.42%) and bornyl acetate (9.95%) and other 28 chemical components.

[0026] Doxorubicin (DOX: commonly used chemotherapeutic drugs of anthracyclines, used to establish animal models of myocardial toxicity), Shenzhen Wanle Ph...

Embodiment 2

[0047] Example 2: Preparation method of Houttuynia volatile oil Huxin Capsules for chemotherapy attenuation and efficiency enhancement

[0048] The health food of Houttuynia cordata volatile oil heart-protecting capsules used for reducing toxicity and enhancing efficacy of chemotherapy comprises two parts: soft capsule content and capsule shell. The content of the soft capsule is by weight 30 parts of Houttuynia volatile oil, 15 parts of hawthorn extract, 8 parts of Ganoderma lucidum extract and 50 parts of soybean oil; the capsule shell is made of 100 parts of gelatin, 40 parts of glycerin, 90 parts of water, 5 parts of sorbitol, 0.5 parts of brown iron oxide. The concrete operation steps of preparation method are:

[0049] (1) Dried houttuynia cordata, hawthorn, and ganoderma lucidum are pulverized by a grinder and passed through a 8-10 mesh sieve to obtain houttuynia cordata powder, hawthorn powder, and ganoderma lucidum powder;

[0050] (2) Weigh the dried Houttuynia cor...

Embodiment 3

[0058] Example 3: Anti-chemotherapy-induced cardiotoxicity attenuation and synergism of Houttuynia volatile oil Huxin Capsules

[0059] 1. Experimental materials

[0060] 1.1 Materials and reagents

[0061] Doxorubicin (DOX: commonly used chemotherapeutic drugs of anthracyclines, used to establish animal models of myocardial toxicity) Shenzhen Wanle Pharmaceutical Co., Ltd.; analytically pure ethanol, Xilong Chemical Co., Ltd., Sigma, USA; IL-1β kit Wuhan Boster Company.

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Abstract

The invention relates to a houttuynia cordata volatile oil heart-protecting capsule for reducing toxicity and enhancing efficacy in chemotherapy and a preparation method thereof. Houttuynia cordata is used as a raw material, the volatile oil of the houttuynia cordata is extracted through a steam distillation method, the volatile oil of the houttuynia cordata is about 20-40 parts by weight, and the auxiliary materials comprise 10-20 parts by weight of hawthorn extract, 5-10 parts by weight of lucid ganoderma extract and 40-60 parts by weight of soybean oil. The product is high in activity and titer, has a myocardial protection effect, and is suitable for tumor patients with cardiotoxicity caused by chemotherapy. The houttuynia cordata volatile oil is derived from natural food materials, is good in safety and clear in chemical components, and has a very good myocardial protection effect; hawthorn in the auxiliary materials of the product can help digestion, invigorate stomach and increase appetite; ganoderma lucidum strengthens the healthy energy and is suitable for crowds suffering from myocardial insufficiency, especially for tumor patients suffering from cardiotoxicity caused by chemotherapy. The product can be used as a chemotherapy partner, is suitable for being used before and after chemotherapy, has a very good protection effect on myocardium, can improve prognosis of tumor patients, and has a relatively good market prospect.

Description

technical field [0001] The invention belongs to the technical field of health food, relates to the technical field of food processing, and in particular relates to the invention of Houttuynia cordata volatile oil heart-protecting capsules with attenuation and efficiency enhancement for myocardial toxicity caused by chemotherapy and a preparation method thereof. Background technique [0002] In the 21st century, due to the surplus of food supply, the disease pattern has changed, and tumor has become an important killer that endangers global health. With the development of treatment technology and the deepening of research fields, tumor treatment has achieved rapid development. Today's cancer treatment combines surgery, chemotherapy, radiotherapy and other methods, which has significantly improved the 5-year survival rate of cancer patients. However, with the use of a large number of chemotherapy drugs, the adverse reactions of drugs, especially cardiovascular adverse reactio...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23L33/115A23L33/10A23L29/281A23L29/30A23L5/42A23P10/30A61K36/78A61K9/48A61P9/00A61P1/14A61P37/04
CPCA23L33/105A23L33/115A23L33/10A23L29/284A23L29/30A23L5/42A23P10/30A61K36/78A61K36/734A61K36/074A61K36/48A61K9/4825A61P9/00A61P1/14A61P37/04A23V2002/00A61K2236/331A61K2236/39A61K2236/51A23V2200/326A23V2250/18A23V2250/21A23V2250/208A23V2250/5432A23V2250/6406A23V2250/642A23V2200/042A61K2300/00
Inventor 李文娟吴文英付王威姚于飞吴伟游慧婷陈晓华吴琼
Owner NANCHANG UNIV
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