Application of ferulic acid derivative in preparation of medicine for convalescent care of ischemic stroke

A technology of ischemic stroke and ferulic acid, which is applied in the field of medicine, can solve the problems of ferulic acid and its sodium salt being weak in activity, difficult to penetrate, and restricting the clinical application of drugs

Inactive Publication Date: 2021-05-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because ferulic acid and its sodium salt have problems such as weak activity and difficulty passing through the blood-brain barrier, these problems restrict its clinical application as a drug in the recovery period of ischemic stroke.

Method used

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  • Application of ferulic acid derivative in preparation of medicine for convalescent care of ischemic stroke
  • Application of ferulic acid derivative in preparation of medicine for convalescent care of ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Therapeutic Effects of Ferulic Acid Derivatives on Mouse Ischemic Stroke (Recovery Period) Model Caused by Thrombosis

[0020] Animal selection and behavioral testing: SPF grade male C57BL / 6 mice, 20-22 g, were fed for 1 week after adaptive feeding, and the behavioral testing was completed by mNSS score and cylinder test, and normal animals were included in the follow-up experiments.

[0021] Determination of cerebral blood flow: The moorFLPI-2 laser speckle blood flow imaging instrument (Moor instruments company, England) was used to measure the basal cerebral blood flow of mice under anesthesia.

[0022] The pMCAO mouse model was established by the thrombus method: the arterial blood of allogeneic mice was taken, and the original thrombus was routinely prepared through a PE catheter (ID = 0.2 mm, OD = 0.38 mm), and stored at 4 °C for future use. After anesthesia, the mice were fixed in the supine position under the operating microscope, and the right common ...

Embodiment 2

[0025] Example 2 Prevention and treatment effect of ferulic acid derivatives on rat ischemic stroke (recovery period) model established by suture embolization method

[0026] Animal selection and behavioral testing: SPF grade male SD rats, 320-340 g, were fed adaptively for 1 week, and the behavioral testing was completed using the optimized neurological function scoring standard (modified neurological severity scores, mNSS) and the cylinder test. Normal animals were included in subsequent experiments.

[0027] mNSS score: The neurological function of rats was detected by mNSS score.

[0028] Cylinder test: place rats in a transparent cylinder (diameter 10 cm, height 15 cm), record the use of the forelimbs of the rats in the exploration activities within 2 minutes, and calculate the use rate of the relative contralateral forelimbs of the rats = (vs. Side forelimb usage ratio / total forelimb usage ratio)×100, so as to evaluate the asymmetry of limb usage.

[0029] The tMCAO ra...

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Abstract

The invention relates to application of a ferulic acid derivative in preparation of a medicine for convalescent care of ischemic stroke. The ferulic acid derivative is characterized in that the ferulic acid derivative is selected from 4-hydroxymethylphenol ferulic acid ester, 4-hydroxybenzylalcohol ferulic acid ester and 4-formylphenol ferulic acid ester.

Description

technical field [0001] The invention relates to the use of a ferulic acid derivative as a medicine for the treatment of ischemic apoplexy in the recovery period, and belongs to the field of medicine. Background technique [0002] Stroke has the characteristics of high morbidity, disability and mortality. It is the second leading cause of death and the first cause of permanent disability in the world. Ischemic stroke is the necrosis of brain tissue caused by insufficient blood supply to the brain, resulting in neurological function, especially motor and sensory dysfunction. Stroke is divided into ischemic and hemorrhagic according to its etiology, of which ischemic stroke accounts for about 80%. According to clinical staging standards, ischemic stroke is usually divided into three pathological stages: acute phase (within 2 weeks of onset), recovery phase (between 2 weeks and 6 months after onset) and sequelae phase (after 6 months of onset). Thrombolytic therapy is mainly u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P9/10
CPCA61K31/216A61P9/10
Inventor 杜俊蓉陈雏吴梅岭郑紫星
Owner SICHUAN UNIV
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