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Local skin external preparation containing arctiin compounds based on solid particle emulsification technology and its preparation method and application

An external preparation, the technology of arctiin, applied in the field of preparations, can solve the problems of weak stable emulsion system, skin safety problems, high equipment requirements, etc., to enhance skin permeability and retention, improve stability, and process easy-to-use effects

Active Publication Date: 2022-03-04
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More and more studies have shown that the application of surfactants will lead to skin safety problems, and at the same time, its effect on stabilizing the emulsion system is not strong and the cost is high
[0003] In addition, the traditional emulsion process is relatively complicated, and usually needs to be heated to above 70°C for emulsification, which is more risky when applied to thermally unstable drugs
At the same time, it may be strictly controlled during the process of cooling down, which requires high equipment, and there are many problems in industrial production.

Method used

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  • Local skin external preparation containing arctiin compounds based on solid particle emulsification technology and its preparation method and application
  • Local skin external preparation containing arctiin compounds based on solid particle emulsification technology and its preparation method and application
  • Local skin external preparation containing arctiin compounds based on solid particle emulsification technology and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] 1. an external preparation matrix of an arctiside compound, comprising:

[0084] 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0085] The preparation method of above-mentioned external preparation matrix comprises the following steps:

[0086] Water and hydroxypropyl cellulose are added to diethylene glycol monoethyl ether to fully swell to obtain an aqueous phase; 244FP is dispersed in light liquid paraffin to obtain an oil phase; the oil phase is added to the water phase and homogenized at a speed of 15,000 rpm for 5 minutes.

[0087] 2. An external preparation of an arctiside compound, comprising:

[0088] Arctium aglycone 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0089] The preparation method of above-mentioned external preparation comprises the following steps:

[0090] Dissolving arctigenin in the re...

Embodiment 2

[0092] An external preparation of an arctiside compound, comprising:

[0093] Arctigoside 5g, 244FP 1.5g, diethylene glycol monoethyl ether 11.5g, hydroxypropyl cellulose 2g, light liquid paraffin 25g, water 60g.

[0094] The preparation method of above-mentioned external preparation comprises the following steps:

[0095] Disperse the arctiside in the recipe quantity in diethylene glycol monoethyl ether, add water and hydroxypropyl cellulose, fully swell to obtain a water phase; 244FP is dispersed in light liquid paraffin to obtain an oil phase; the oil phase is added to the water phase and homogenized at a speed of 15,000 rpm for 5 minutes.

Embodiment 3

[0097] An external preparation of an arctiside compound, comprising:

[0098] Arctium aglycone 2.5g, MCG 591P 5g, propylene glycol 20g, povidone K30 5g, dimethicone 10g, water 57.5g.

[0099] The preparation method of above-mentioned external preparation comprises the following steps:

[0100] Dissolve the prescribed amount of arctigenin in propylene glycol, add water and povidone K30, dissolve fully, and then add MCG 591P, disperse uniformly to obtain the water phase; add dimethicone as the oil phase to the water phase, and homogenize at a speed of 7000 rpm for 20 minutes.

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Abstract

The embodiments of the present invention relate to the field of preparations, and in particular to local external skin preparations loaded with arctiin compounds based on solid particle emulsification technology, its preparation method and application. The external preparation of arctiin compounds provided in the embodiments of the present invention includes the following components in parts by weight: 1-15 parts of arctiin or arctigenin, 0.5-10 parts of solid particle emulsifier, and 10-40 parts of oil phase part, 5-30 parts of solubilizer, and 1-10 parts of thickener; the particle diameter of described solid particle emulsifier is nanometer or micron order. In the external preparations of arctiin compounds provided in the examples of the present invention, the arctiin compounds are passed through a solid particle emulsifier to form a stable and efficient system, which can release drugs stably during the administration process. In addition, compared with the traditional emulsion, the external preparation of the present invention also enhances the skin permeability and retention of the arctium glycerin compounds, showing better pharmacological activity and curative effect.

Description

technical field [0001] The invention relates to the field of formulations, in particular to a topical skin external preparation containing arctiside compounds based on solid particle emulsification technology and a preparation method and application thereof. Background technique [0002] Emulsion is one of the main dosage forms of topical therapy, and its advantages are to protect the encapsulated drug while increasing its solubility and improving the skin penetration behavior of the drug. Since emulsions are thermodynamically unstable systems, stabilizers are needed to form a stable system and ensure its long-term stability. To date, most emulsions have been stabilized by synthetic surfactants. More and more studies have shown that the use of surfactants will lead to skin safety issues, while their role in stabilizing emulsion systems is not strong and the cost is high. [0003] In addition, the traditional emulsion process is relatively complicated, and usually needs to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/365A61K31/7048A61K47/02A61K47/04A61K47/32A61K47/36A61K47/38A61P17/00A61P17/06
CPCA61K31/365A61K31/7048A61K47/38A61K47/32A61K47/36A61K47/02A61K9/0014A61K9/107A61P17/00A61P17/06
Inventor 许叶春唐炜罗华菲林国钡
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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