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Preparation method of PEG/PEI-modified magnetic nanoparticles

A magnetic nanoparticle and iron particle technology, applied in the field of biomedicine, can solve the problems of endoplasmic reticulum phagocytosis, insufficient active targeting of the carrier system, and difficult tumor tissue localization and retention.

Pending Publication Date: 2021-05-14
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1. The active targeting of the carrier system is insufficient, and the movement of magnetic nanoparticles in the blood will be affected by both the blood flow velocity and the magnetic field strength, which means that a sufficiently large magnetic field strength needs to be established against the linear flow velocity of blood in the tissue to make the drug The carrier arrives and remains in the treatment area
[0009] 2. Superparamagnetic particles are too small in size, easy to be swallowed by endoplasmic reticulum and difficult to locate and stay in tumor tissue
[0010] 3. Superparamagnetic particles are prone to agglomeration

Method used

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  • Preparation method of PEG/PEI-modified magnetic nanoparticles
  • Preparation method of PEG/PEI-modified magnetic nanoparticles
  • Preparation method of PEG/PEI-modified magnetic nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1. Preparation of Vortex Iron Particles:

Embodiment 1-1

[0082] Embodiment 1-1 Preparation of annular vortex iron particles:

[0083] Synthesis of α-Fe by Hydrothermal Method 2 o 3 nanorings, the reactant is FeCl 3 ·6H 2 O, the introduced surfactant is NH 4 h 2 PO 4 and Na 2 SO 4 . Weigh 0.43g of FeCl 3 ·6H 2 O, 0.00092 g NH 4 h 2 PO 4 and 0.00625g of Na 2 SO 4 , Dissolve it in distilled water, stir the mixture vigorously on a magnetic stirrer until evenly mixed, then transfer it to a stainless steel autoclave, put it in an oven at 220°C, and react at a constant temperature for 48 hours. After cooling to room temperature, wash, Centrifuge to obtain the desired precipitate. Finally dry to obtain the desired α-Fe 2 o 3 nanoring particles. Then the prepared α-Fe 2 o 3 As raw material, Fe was obtained by hydrogen reduction method 3 o 4 Nano rings, the final product ring Fe 3 o 4 nanoparticles. TEM as Figure 1a shown.

Embodiment 1-2

[0084] Embodiment 1-2 Preparation of rod-shaped vortex iron particles:

[0085] Weigh 0.432g of FeCl 3 ·6H 2 O and 0.0046gNH 4 h 2 PO 4 , add a small amount of distilled water to dissolve and stir vigorously. When the solute is completely dissolved, the mixture is transferred to a stainless steel autoclave, hydrothermally treated at 205°C for 48 hours, cooled to room temperature, washed, and dried at 60°C for 24 hours to obtain rod-like α-Fe 2 o 3 nanoparticles. Then use the prepared α-Fe 2 o 3 As a raw material, Fe was prepared by the hydrogen reduction method 3 o 4 Nano stave. The dried α-Fe 2 o 3 The powder was annealed at 500 °C in a continuous hydrogen / argon flow, and then cooled to room temperature while maintaining a continuous hydrogen flow to obtain the final product rod-shaped Fe 3 o 4 nanoparticles. TEM such as Figure 1b shown.

[0086] Examples 1-3 Spherical Vortex Iron Particles.

[0087] Such as Figure 1c As shown, the test results of magnet...

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Abstract

The invention provides a preparation method of magnetic nanoparticles. The preparation method is characterized by comprising the following steps: S1, adding alcohol into vortex iron particles, and dispersing the vortex iron particles via ultrasonic treatment; S2, carrying out magnetic adsorption separation to remove alcohol; S3, adding PEG and / or PEI and water, and performing ultrasonic emulsification; and S4, discarding a supernatant, conducting washing with water and alcohol respectively, collecting a precipitate, and drying the precipitate to obtain the PEG and / or PEI modified magnetic nanoparticles. The obtained nano-carrier is low in toxicity and good in effect.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a nanocarrier, and more specifically to a preparation method and application of PEG / PEI-modified magnetic nanoparticles. Background technique [0002] Magnetic nanoparticles, due to the nano-size effect, exhibit physical and chemical properties that are completely different from those of macroscopic magnetic materials, such as: large specific surface area, superparamagnetic properties, and diverse topological magnetic structures, etc. It can be assembled and positioned under a constant magnetic field, making it widely used in biomedical fields such as targeted drug carriers and magnetically controlled drug release, absorbing electromagnetic waves under an alternating magnetic field to generate heat for tumor hyperthermia. [0003] In the prior art, liver cancer-specific therapeutic genes are constructed by using liver cancer-specific promoters and hypoxia-responsive sequences to guide ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/59A61K47/60A61K9/50A61K47/46A61K41/00A61K31/704B82Y5/00B82Y25/00B82Y30/00B82Y40/00A61P35/00
CPCA61K47/60A61K47/59A61K47/6923A61K41/00A61K9/0009B82Y5/00B82Y25/00B82Y30/00B82Y40/00A61K9/5068A61K31/704A61P35/00
Inventor 刘艳李翔陆云姝顾芬芬李若男达先鸿
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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