Multi-component combined solution as well as preparation method and application thereof

A multi-component, solution technology, applied in the field of daily chemical skin care, can solve the problems of skin barrier repair, anti-allergy, anti-oxidation, etc., to increase skin anti-oxidation and anti-inflammatory effects, soothe and improve the state of sensitive skin, Promoting Tight Junction Effects

Pending Publication Date: 2021-05-04
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above-mentioned raw materials all have a single or similar single effect in each of the above-mentioned raw materials, they cannot have the effects of skin barrier repair, anti-allergic, anti-oxidation, etc.

Method used

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  • Multi-component combined solution as well as preparation method and application thereof
  • Multi-component combined solution as well as preparation method and application thereof
  • Multi-component combined solution as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Proportions are made according to the aforementioned Table 1, and the proportions of Combination 3 are used as an example, that is, 5% collagen, 5% thiotaurine, 50% hot spring water, and 40% deionized water by weight. The preparation process is as follows:

[0031] ·Filtrate the untreated hot spring water to remove impurities in the water (pass through 5 micron PP cotton, granular activated carbon and 1 micron PP cotton filter in turn), and test the conductivity, which is within the range of less than 500μS / cm.

[0032] ·Heat the deionized water to 80 degrees Celsius, keep it for 30 minutes, and cool down. Then get 50g hot spring water and add 40g deionized water.

[0033] ·Weigh 5g of thiotaurine and add it into the above aqueous solution, stir to disperse and dissolve.

[0034] Weigh 5g of collagen and add it to the above aqueous solution, use a glass rod to stir for preliminary dispersion, use a homogenizer to disperse and homogenize, adjust the rotation speed of t...

Embodiment 2

[0036] The following efficacy tests were carried out on the multi-component combination solution obtained by the above-mentioned preparation method. Among them, they are respectively called combination 1-combination 5 according to the ratio, and the single-component samples are respectively 0.05% concentration of collagen solution, 0.05% concentration of thiotaurine solution and 0.5% concentration of Riduo hot spring water solution:

[0037] 1. Efficacy test based on epidermal model

[0038] The purpose of the test is to compare the effects of the three components and their compositions on the epidermal model, and to evaluate their effects on skin barrier repair.

[0039] testing method:

[0040]Normal human keratinocytes in the logarithmic growth phase were digested and resuspended, and inoculated at 1.0Mcells / mL into the Millicell, a hanging culture chamber matching a 24-well plate, and the culture medium was added to the chamber and the receiving well, and the control grou...

Embodiment 3

[0049] Collagen-containing ingredient combination genetic testing

[0050] Skin aging is a complex physiological phenomenon affected by many factors. There are two main forms of aging, natural aging and photoaging. Natural aging is aging caused by genes or age, and photoaging is aging caused by ultraviolet radiation. The skin begins to age at the age of 25, and the aging of the skin is more obvious at the age of 40-50. Healthy skin has high water content, smooth and fine lines, and full of elasticity. With age, it is affected by external environmental factors such as ultraviolet rays, pollution, and chemicals. , the water-retaining components of the cells will gradually decrease. When the water content is lower than a certain level, the skin will be rough, and in severe cases, there will be external manifestations such as wrinkles. Therefore, it is of great significance to study how to increase the expression of moisturizing-related genes and anti-aging genes, maintain skin m...

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PUM

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Abstract

The invention relates to a multi-component combined solution. The multi-component combined solution is characterized by comprising the following components in percentage by weight of 1 to 10 percent of collagen, 1 to 10 percent of thiotaurine, 10 to 50 percent of thermal spring water and 30 to 88 percent of deionized water. Deionized water and thermal spring water are used as solvents, collagen and thiotaurine are added, and a multi-component combined solution is formed. Experimental results show that the composition has an obvious effect on tissue structure and loricrin / involucrin expression of an epidermis model, has a positive regulation effect on dermal capillary endothelial cells, and has a correct response to a capillary permeability control regulation factor; and meanwhile, the multi-component combined solution has obvious effects on resisting lipid peroxidation and inflammation of skin keratinocytes.

Description

technical field [0001] The invention relates to the field of daily chemical skin care, in particular to a multi-component combination solution and a preparation method thereof. Background technique [0002] In recent years, the occurrence of sensitive skin in my country has been increasing. A survey in 2011 showed that about 46% of Chinese women and 30% of Chinese men had skin sensitivity to varying degrees (Journal of Clinical Dermatology, 2011, 40(4): 261.). However, there is still no unified statement on the cause of sensitive skin. It may be related to factors such as skin barrier function damage, inflammatory response, increased nerve sensitivity, and abnormal changes in sebum. Due to the complexity of the causes and mechanisms of sensitive skin, there is currently no effective treatment. Studies have shown that the abuse of cosmetics may lead to sensitive skin, and the use of soothing cosmetics can help improve sensitive skin. Therefore, targeted daily skin care is v...

Claims

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Application Information

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IPC IPC(8): A61K8/96A61K8/65A61K8/46A61K8/04A61Q19/00A61Q19/08
CPCA61K8/65A61K8/466A61K8/965A61Q19/005A61K8/04A61Q19/08
Inventor 章漳蒋丹丹蒋耀权王风楼黄俊
Owner JALA GROUP CORPORATION
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