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Green process for extracting high-purity bakuchiol

A bakuchiol, green technology technology, applied in the field of green technology, can solve the problems of large solvent consumption, cumbersome process steps, low yield and the like

Active Publication Date: 2021-04-30
AKTIN CHEM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The above-mentioned preparation method of bakuchiol has cumbersome process steps, large solvent consumption, uneconomical, environmental protection, and low yield

Method used

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  • Green process for extracting high-purity bakuchiol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 bakuchiol

[0039] Proceed as follows:

[0040](1) Supercritical extraction: 5 kg of dried psoraleae, crushed to 80 mesh, put into an extraction kettle, and extracted with supercritical carbon dioxide; the extraction temperature is 40°C, the extraction pressure is 30Mpa, and the flow rate of carbon dioxide is 20L / h, After equilibrating for 20 minutes, flow extraction; extraction for 2 hours; the pressures of the analysis kettles A and B were 8Mpa and 6Mpa, and the temperatures were 45°C and 40°C, respectively, and analyzed to obtain 780mL of yellow oily liquid containing bakuchiol.

[0041] (2) Preliminary separation: the oily liquid was dissolved with 8000 mL of petroleum ether, filtered to remove highly polar insoluble matter, and the filtrate was concentrated under reduced pressure to obtain 418 g of bakuchiol crude extract.

[0042] (3) Purification by column chromatography: load the crude bakuchiol extract onto a silica gel chromato...

Embodiment 2

[0043] The preparation of embodiment 2 bakuchiol

[0044] Proceed as follows:

[0045] (1) Supercritical extraction: 5 kg of dried psoraleae, crushed to 100 mesh, put into an extraction kettle, and extracted with supercritical carbon dioxide; the extraction temperature is 45°C, the extraction pressure is 30Mpa, and the flow rate of carbon dioxide is 20L / h, After equilibrating for 20 minutes, flow extraction; extraction for 3 hours; the pressures of the analysis kettles A and B were 10Mpa and 8Mpa, respectively, and the temperatures were 30°C and 25°C respectively, and the analysis was carried out to obtain 760mL of oily liquid containing bakuchiol.

[0046] (2) Preliminary separation: the oily liquid was dissolved with 5000 mL of petroleum ether, filtered to remove large polar insoluble matter, and the filtrate was concentrated under reduced pressure to obtain 433 g of bakuchiol crude extract.

[0047] (3) Purification by column chromatography: load the crude bakuchiol extrac...

Embodiment 3

[0048] The preparation of embodiment 3 bakuchiol

[0049] Proceed as follows:

[0050] (1) Supercritical extraction: dry 5 kg of psoraleae, crush it to 40 mesh, put it in an extraction kettle, and extract with supercritical carbon dioxide; extraction temperature is 45°C, extraction pressure is 30Mpa, flow rate of carbon dioxide is 25L / h, and balance for 20 minutes After flow extraction; extraction for 2 hours; the pressures of the analysis kettles A and B were 15Mpa and 10Mpa respectively, and the temperatures were 50°C and 30°C respectively, and the analysis was carried out to obtain 740mL of oily liquid containing bakuchiol.

[0051] (2) Preliminary separation: the oily liquid was dissolved with 9000 mL of n-hexane, filtered to remove the large polar insoluble matter, and the filtrate was concentrated under reduced pressure to obtain 420 g of bakuchiol crude extract.

[0052] (3) Purification by column chromatography: load the bakuchiol crude extract on an alumina chromatog...

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Abstract

The invention discloses a green process for extracting and purifying bakuchiol from fructus psoraleae, and belongs to the technical field of preparation of plant extracts. According to the process, the bakuchiol in the fructus psoraleae is extracted by adopting a carbon dioxide supercritical extraction technology, the bakuchiol with the purity of more than 98% is obtained by applying a column chromatography technology after primary separation of removing high-polarity insoluble substances by dissolving treatment of a low-polarity organic solvent, and the yield is more than 5.0%. The process is an efficient environment-friendly process, and a sample is high in yield and purity. The process is simple in process, safe, good in controllability, low in cost, short in production period and suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a green process for extracting and purifying bakuchiol from psoraleae, belonging to the technical field of preparation of plant extracts. Background technique [0002] Psoraleae Fructus, a traditional Chinese medicine, is the dry and mature fruit of Psoralea corylifolia L., a leguminous plant. Harvest the infructome when the fruit is ripe in autumn, dry it in the sun, rub out the fruit, and remove impurities. [0003] There are about 120 species of Psoralea Linn. in the world, mainly distributed in southern Africa, North and South America and Australia, a few in Asia and temperate Europe, and only one species in China. Psoraleae was originally an imported medicinal material, and later it was widely cultivated in my country. It is mainly produced in Yunnan, Sichuan, Henan and other places in my country, and it is cultivated in other places. [0004] Psoraleae is pungent, bitter and warm in nature, returns to the kidney and spl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/82C07C37/72C07C39/19
CPCC07C37/82C07C37/72C07C39/19Y02P20/54
Inventor 付书清张林徐敏曹怀塘
Owner AKTIN CHEM INC
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