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Acrylate polymer microsphere aggregate and preparation method thereof

An acrylate and polymer technology, applied in the field of acrylate polymer microsphere aggregate powder dressing, can solve the problems of low absorption capacity, high product cost, allergy to ingredients, etc.

Active Publication Date: 2021-04-13
陈忠 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its absorption capacity is not very strong, so for highly exudative wounds, it is often necessary to use other auxiliary dressings to enhance absorption performance; the product cost is high; individual patients may have shortcomings such as allergies to ingredients

Method used

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  • Acrylate polymer microsphere aggregate and preparation method thereof
  • Acrylate polymer microsphere aggregate and preparation method thereof
  • Acrylate polymer microsphere aggregate and preparation method thereof

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preparation example Construction

[0074] The present invention introduces new technical means in the preparation process of acrylate polymer microspheres so that the inside of the synthesized polymer microspheres has microporous channels, and new capillary channels are formed when the polymer microspheres aggregate during the drying process. The interaction of the pores makes the acrylate polymer powder fuse together quickly to form a polymer film with good water-permeable and air-permeable properties when encountering moisture-containing substances, thereby promoting the wet healing of wounds.

[0075] The present invention adopts core-shell emulsion polymerization to prepare microphase-separated polymer microspheres, first synthesizing a polymer core containing more hydrophilic monomers, and then adopting a continuous dropping process to prepare polymers containing more lipophilic monomers The shell controls the cross-linking density and ionization degree of the core and the shell, so that in the post-process...

Embodiment 1

[0137] A kind of acrylate polymer microsphere aggregate is prepared by the following steps:

[0138] (1) The preparation process of the core: Weigh 1.0 g of emulsifier sodium dodecyl sulfate (SDS) and 380 g of deionized water into a 500 mL four-neck flask, and then install a stirrer, nitrogen conduit, thermometer and condenser tube, The temperature of the water bath is maintained at 73°C, and the nitrogen gas is continuously introduced and the stirring is started. When the emulsifier is completely dissolved and the internal temperature reaches 70±1°C, add the pre-weighed monomer mixture, which contains 12g of hydroxyethyl methacrylate (HEMA), 8g hydroxypropyl methacrylate (HPMA), 1g methacrylic acid (MAA) and 0.4g diacetone acrylamide (DAAM), after the temperature stabilizes, add pre-dissolved potassium persulfate (KPS) The solution, which contained 0.1 g KPS and 20 g deionized water, was started. After about 5 minutes, the reactants showed blue light, and the monomers began ...

Embodiment 2

[0148] A kind of acrylate polymer microsphere aggregate is prepared by the following steps:

[0149] (1) The preparation process of the nucleus: Weigh 1.5g of emulsifier SDS and 380g of deionized water into a 500mL four-neck flask, and then install a stirrer, nitrogen conduit, thermometer and condenser. The temperature of the water bath is maintained at 73°C, and the Introduce nitrogen and start stirring. When the emulsifier is completely dissolved and the internal temperature reaches 70±1°C, add the pre-weighed monomer mixture, which contains 16g HEMA, 4g HPMA, 1.5g MAA and 0.2g DAAM. After stabilization, add the pre-dissolved KPS solution, which contains 0.15g KPS and 20g deionized water, and start the timer. After about 5 minutes, the reactants showed blue light, and the monomers began to polymerize to form polymer particles. After about 6 hours, the nucleus preparation reaction was completed.

[0150] (2) Weigh 200g of nuclear emulsion and 190g of deionized water into a 5...

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Abstract

The invention provides an acrylate polymer microsphere with a capillary function. The acrylate polymer microsphere has a core-shell structure, and the hydrophilicity of the core layer is stronger than that of the shell layer. The invention further provides a method for preparing the acrylate polymer microsphere, and the acrylate polymer microsphere has different hydrophilic properties by adjusting the monomer composition and proportion of the core layer and the shell layer. By adjusting the pH value, the core-layer linear polymer is unfolded and forms an interpenetrating network structure with the shell-layer cross-linked polymer. A cross-linking agent is added to react with the core-layer linear polymer so that the core-layer linear polymer is cross-linked to form a stable polymer interpenetrating network structure. After drying, micropore channels left after water in the microspheres is lost are supported and stabilized due to the existence of a cross-linked network. The acrylate polymer microsphere aggregate disclosed by the invention can be used as a dressing.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to an acrylate polymer microsphere aggregate powder dressing with capillary action. Background technique [0002] Medical dressings are medical materials used to cover sores, wounds or other damage. With the in-depth study of the pathophysiology of the wound healing process, people's understanding of the wound healing process has become more and more profound, which has led to the continuous improvement and development of medical wound dressings. [0003] Natural gauze is the earliest and most widely used type of dressing. However, it has too high permeability, which is easy to dehydrate the wound surface; it adheres to the wound surface, and it will cause mechanical damage again when it is replaced; it is easy for microorganisms in the external environment to pass through, and the chance of cross-infection is high; the dosage is large, the replacement is frequent, time-consuming, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F265/06C08F220/20C08F220/14C08F222/14C08J9/28C08L51/00A61L26/00
CPCC08F265/06C08J9/28A61L26/0014A61L26/0061A61L26/0085C08J2351/00C08L33/08C08F220/20C08F220/14Y02E60/10
Inventor 陈忠项炜
Owner 陈忠
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