A kind of cellulose graft copolymer and its preparation method and application in injectable hydrogel

A technology of cellulose graft and copolymer, applied in the field of cellulose graft copolymer and its preparation, to achieve the effects of strong operability, good slow-release effect and simple process

Active Publication Date: 2022-04-22
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And there are also a large number of researchers using ATRP technology to prepare cellulose self-assembled polymers, but no researchers have done systematic research on the preparation of responsive injectable drug-loaded hydrogels using ATRP technology as a raw material.

Method used

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  • A kind of cellulose graft copolymer and its preparation method and application in injectable hydrogel
  • A kind of cellulose graft copolymer and its preparation method and application in injectable hydrogel
  • A kind of cellulose graft copolymer and its preparation method and application in injectable hydrogel

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Embodiment 1

[0037] The preparation method of cellulose-based injectable hydrogel is as follows:

[0038] (1) Dissolution of cellulose: LiCl / DMAc system was used to dissolve cellulose. First, 6 g of cellulose and 18 g of LiCl were dried in a vacuum oven at 100 °C for 24 h, and then the dried cellulose was added to 176 g of N,N-di In methylacetamide (DMAc), the mixture was then activated at 160°C for 2 hours at high temperature, then LiCl was added and the temperature was lowered to 100°C, kept for several hours, then lowered to room temperature and stirred until completely dissolved.

[0039] (2) Formation of cellulose macromolecular initiator: get 54g of the above-mentioned solution in the Xinweier reaction flask that rotor is housed, then add 7.5ml 2-bromoisobutyryl bromide (BIBB) dropwise with constant pressure separatory funnel in Reaction at room temperature for 12h. After the reaction was completed, the mixture was poured into 100 ml of deionized water, followed by centrifugal washi...

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Abstract

The invention discloses a cellulose graft copolymer, its preparation method and its application in injectable hydrogel. Cellulose was dissolved using lithium chloride / N,N-dimethylacetamide (LiCl / DMAc) system, then the cellulose solution was transferred to a round-bottomed flask, and 2-bromoisobutyryl bromide (BIBB) was introduced to react Formation of cellulose macromolecular initiators. The cellulose macroinitiator uses N-isopropylacrylamide (NIPAAm) as the monomer, pentamethyldiethylenetriamine / cuprous bromide (PMDETA / CuBr) as the catalyst system, and N,N-dimethyl Dimethyl formamide (DMF) is a solvent-synthesized cellulose graft copolymer. The cellulose graft copolymer of the present invention is a flowable liquid at normal temperature when the concentration is higher than 5%, and forms a non-flowable hydrogel when it is above 37°C, so it has potential in the field of injectable drug-loaded hydrogels application.

Description

technical field [0001] The invention relates to the field of injectable hydrogels, in particular to a cellulose graft copolymer, a preparation method thereof and an application in injectable hydrogels. Background technique [0002] In recent years, injectable hydrogels have received extensive attention due to their advantages such as minimal surgical trauma. Among them, stimuli-responsive smart hydrogels can respond to self-assembly or disassembly under external stimuli (such as temperature, pH, and light, etc.), so such hydrogels have great application prospects in the field of drug release. However, the large-scale use of synthetic polymers is limited by high price and potential toxicity. Therefore, injectable stimuli-responsive hydrogels based on natural polysaccharides are widely available, low in price, safe, non-toxic, and biologically compatible. Advantages such as compatibility and biodegradability have received more and more attention. As one of the natural polysa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/02C08F220/54A61K9/00A61K9/06A61K9/107A61K31/704A61K47/38
CPCC08F251/02A61K9/06A61K9/1075A61K9/0024A61K47/38A61K31/704C08F220/54
Inventor 付时雨刘小红
Owner SOUTH CHINA UNIV OF TECH
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