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Traditional Chinese medicine composition for treating allergic rhinitis and application thereof

A technology of allergic rhinitis and composition, which is applied to the traditional Chinese medicine composition for the treatment of allergic rhinitis and its application field, which can solve the problems of unsatisfactory treatment effect and side effects of systemic hormones, so as to improve the pathology of rhinitis and reduce the secretion of nasal mucosa The effect of mucin

Active Publication Date: 2021-04-13
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the therapeutic effects of western medicine are not satisfactory in clinic. The local application of corticosteroids in the nasal cavity is used for anti-allergy, and the local application of ephedrine in the nasal cavity is mainly used to shrink blood vessels.
Topical application of corticosteroids in the nasal cavity will be absorbed into the blood for long-term application, causing side effects of systemic hormones

Method used

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  • Traditional Chinese medicine composition for treating allergic rhinitis and application thereof
  • Traditional Chinese medicine composition for treating allergic rhinitis and application thereof
  • Traditional Chinese medicine composition for treating allergic rhinitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057]Take 1000 kg of dust to add 6000 ml of water, water vapor distillation, and obtain extracts containing butovol (clove phenol purity), distilled 2 times, the volume is 10000ml, i.e., the lilac extract; concentration of luminous vacuum, The lilac extract (about 100 g), wherein the phenol purity is 80%.

[0058]Take 1000 grams of jaundice, add 5000 ml of 70% ethanol to extract 2 times, vice ethanol, add it to the D101 resin column, and then flush with a 5-fold amount of water, and then use 0.2% NaOH to wash the column, wash to neutrality, 20% ethanol puncturing column, wash the column with 70% ethanol and collected, and ethanol, 2000 ml of Astragalus extract solution (70% pure saponin) rich in astragalic saponin (70% pure saponin), and 0.3% sorbitate preparation. Among them, after the ethanol is lighted, dry, and a bruises extract (about 20 g), and the purity of Astragalus sum saponin is 70%.

[0059]The 1000 ml of the lilac extract solution and 1000 ml of Astragalus extract solution w...

Embodiment 2

[0063]Purchase 10 g of lilac phenol (90% purity) from the market, dissolved in Tween 80, diluted into 1000ml; 20g of Huang Xu total saponins (purity 90%), dissolved in Tween 80, diluted to 1000 mL; Press 1: 1 Mixed, dispensed into 200 bottles of 10 ml of nose.

Embodiment 3

[0065]Take 1000 cars, pulverized into coarse powder, placed in a supercritical extraction equipment, the pressure is 25 MPa, the temperature is 55 ° C, and the pressure is 6 MPa, the temperature is 40 ° C, resulting in a pale yellow translucent extract 100 Gram (phenol purity was 80%), and a solubilized Tween 80 was added and diluted to end volume of 10000 ml, i.e., a lilac extract solution.

[0066]Take 1000 grams of jaundice, add 5000 ml of water to extract 2 times, then extract the n-butanol extracted with water, take the n-butanol layer liquid, swine n-butanol, water absolute ethanol, dissolve with water, 2000ml rich bruises total saponins The extract solution (astragalus total saponin purity is 70%), and 0.3% sorbitate is prepared. Among them, after absolute ethanol is cleaned, dried, and the Astragalus extract (about 20 g) is obtained, and the purity of Astragalus sum Saponin is 70%.

[0067]The 1000 ml of the lilac extract solution and 1000 ml of Astragalus extract solution were mi...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis and application thereof. The traditional Chinese medicine composition is prepared from eugenol and total saponins of radix astragali seu hedysari. A nasal spray prepared from the traditional Chinese medicine composition can be used for treating allergic rhinitis through local nasal administration, has an experimental drug effect superior to that of a first-line treatment drug, takes effect quickly, can take effect after being sprayed for 1-3 minutes, reduces nasal obstruction, running nose and the like, has no side effect, and can achieve a radical treatment effect on part of people. After the nasal spray is administrated to rats, the results show that the nasal spray for the corydalis bungeana group is superior to triamcinolone acetonide (positive control group) in the aspects of reducing a main allergic medium IgE, reducing nasal mucous membrane secretory mucoprotein MUC5AC and improving rhinitis pathology, the eugenol and the total saponins of radix astragali seu hedysari are matched to play a synergistic effect, and the effect exceeds that of single eugenol and single total saponins of radix astragali seu hedysari.

Description

Technical field[0001]The present invention relates to a nasal, nose, nose, nose, and nose, which treat allergic rhinitis, in combination with traditional Chinese medicine, and particularly to a Chinese medicine composition for treating allergic rhinitis. The Chinese medicine composition consists of a lilac phenol, astragalus sum Saponin. The nasal agents made of the Chinese medicine composition according to the present invention can be used to treat allergic rhinitis, and the experiment is superior to the first-line therapeutic drug: corticosteroid preparation, and the advantages of side effects of hormones.Background technique[0002]Allergic rhinitis (allergic rhinitis) is an immunogenic allergy and chronic inflammatory disease in an immunogenic allergy and chronic inflammatory, which affects more than 20% of the population of more than 20% of the world in recent years. Come, including China's incidence, the incidence of countries has always been an upward.[0003]At present, the trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K36/61A61K9/12A61K9/06A61K9/08A61K47/10A61K47/32A61P11/02A61P37/08A61K31/085
CPCA61K31/085A61K36/481A61K36/61A61K9/0043A61K9/08A61K9/12A61K9/06A61K47/10A61K47/32A61P11/02A61P37/08A61K2236/331A61K2236/39A61K2236/333A61K2236/55A61K2236/35A61K2300/00
Inventor 王剑
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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