Application of AR inhibitor and/or HIF-1[alpha] inhibitor in preparation of medicine
A technology of HIF-1 and α inhibitors, applied in drug combination, compound screening, antipyretic drugs, etc., can solve the problems of not improving the outcome of critically ill patients, and achieve the goal of improving clinical curative effect, significant curative effect, and maintaining lung function Effect
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Embodiment 1
[0053] Using bioinformatics Seurat 3.0 and Single R software to analyze the single-cell transcriptome sequencing data of patients with severe COVID-19 and uninfected patients, it was found that the expression level of HIF-1α in lung fibroblasts of infected patients was much higher than that of uninfected patients Expression levels of HIF-1α in lung fibroblasts.
[0054] Single-cell transcriptome sequencing data of patients with novel coronavirus pneumonia: GSM4516279, GSM4516280, GSM4516281, GSM4516282 Data website: https: / / www.ncbi.nlm.nih.gov / geo.
[0055] Single-cell transcriptome sequencing data of uninfected patients with novel coronavirus pneumonia: E-MTAB-6149, E-MTAB-6653 data website: https: / / www.ebi.ac.uk / arrayexpress.
[0056] Analysis results such as figure 1 As shown, it shows that HIF-1α is highly expressed in lung fibroblasts of patients with severe new coronary pneumonia.
Embodiment 2
[0058] The combination of HIF-1α and AR in the promoter regions of related genes (IL6, MMP2, MMP13, ADAMTS4, ELN, VCAN, COL3A1, VEGFA) was analyzed by TFmapper and UCSC Genome Browser bioinformatics analysis website tools. The results of bioinformatics analysis showed that HIF-1α and AR could bind to the promoter regions of related genes (IL6, MMP2, MMP13, ADAMTS4, ELN, VCAN, COL3A1, VEGFA), thereby affecting the transcription of related genes.
Embodiment 3
[0060] Figure 3A The expression levels of ACE2 and TMPRSS2 genes were analyzed by bioinformatics Seurat 3.0 and Single R software to analyze the single-cell transcriptome sequencing data of severe patients with new coronary pneumonia and the single-cell transcriptome sequencing data of uninfected patients with new coronary pneumonia.
[0061] Single-cell transcriptome sequencing data of patients with novel coronavirus pneumonia: GSM4516279, GSM4516280, GSM4516281, GSM4516282 Data website: https: / / www.ncbi.nlm.nih.gov / geo.
[0062] Single-cell transcriptome sequencing data of uninfected patients with novel coronavirus pneumonia: E-MTAB-6149, E-MTAB-6653 data website: https: / / www.ebi.ac.uk / arrayexpress.
[0063] Analysis results such as Figure 3A As shown, the experimental results showed that the expression levels of ACE2 and TMPRSS2 genes in lung fibroblasts of patients with severe new coronary pneumonia and those without new coronary pneumonia were low and there was no sign...
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