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Famciclovir tablet composition

A technology of famciclovir and composition, which is applied in the field of famciclovir tablet composition, can solve problems such as difficult storage, high proportion, and increased dosage units for patients, and achieve the effects of improved moisture resistance, good fluidity, and uniform particles

Active Publication Date: 2021-04-02
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main drug amount of famciclovir accounts for a high proportion of the prescription volume, and it is not easy to store it in the outsourcing method. In order to achieve a better moisture-proof effect, it is necessary to reduce the proportion of the main drug amount of famciclovir in the prescription volume by adding hydrophobic auxiliary materials or crystal water auxiliary materials. ratio, resulting in patients taking more units

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. Prescription:

[0025] .

[0026] Step 1. Weigh the famciclovir and lactose monohydrate of the prescribed amount and mix them evenly to obtain mixture A;

[0027] Step 2. Dissolve hydroxypropyl cellulose L, D-glucosamine hydrochloride in 50% ethanol solution under stirring, and stir until completely dissolved to form a uniform transparent liquid to obtain mixture B;

[0028] Step 3. Add the mixed material A into the fluidized bed granulator, turn on the granulator, spray the mixture B into the fluidized bed for granulation and drying, and obtain the granule I;

[0029] Step 4. The granule I is granulated, and then mixed evenly with the prescribed amount of carboxymethyl starch sodium and magnesium stearate to obtain the granule II;

[0030] Step 5. The granule II is compressed into tablets to obtain 1000 famciclovir tablets.

Embodiment 2

[0031] Example 2. Prescription

[0032] .

[0033] Step 1. Weigh the famciclovir and lactose monohydrate of the prescribed amount and mix them evenly to obtain mixture A;

[0034] Step 2. Dissolve hydroxypropyl cellulose L, D-glucosamine hydrochloride in 50% ethanol solution under stirring, and stir until completely dissolved to form a uniform transparent liquid to obtain mixture B;

[0035] Step 3. Add the mixed material A into the fluidized bed granulator, turn on the granulator, spray the mixture B into the fluidized bed for granulation and drying, and obtain the granule I;

[0036] Step 4. The granule I is granulated, and then mixed evenly with the prescribed amount of carboxymethyl starch sodium and magnesium stearate to obtain the granule II;

[0037] Step 5. The granule II is compressed into tablets to obtain 1000 famciclovir tablets.

Embodiment 3

[0038] Example 3. Prescription

[0039] .

[0040] Step 1. Weigh the famciclovir and lactose monohydrate of the prescribed amount and mix them evenly to obtain mixture A;

[0041] Step 2. Dissolve hydroxypropyl cellulose L, D-glucosamine hydrochloride in 50% ethanol solution under stirring, and stir until completely dissolved to form a uniform transparent liquid to obtain mixture B;

[0042] Step 3. Add the mixed material A into the fluidized bed granulator, turn on the granulator, spray the mixture B into the fluidized bed for granulation and drying, and obtain the granule I;

[0043] Step 4. The granule I is granulated, and then mixed evenly with the prescribed amount of carboxymethyl starch sodium and magnesium stearate to obtain the granule II;

[0044] Step 5. The granule II is compressed into tablets to obtain 1000 famciclovir tablets.

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PUM

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Abstract

The invention relates to a famciclovir tablet composition, and belongs to the technical field of pharmaceutical preparations. According to the technical scheme, the famciclovir composition contains the following components in parts by mass of 75.8 parts of famciclovir, 6.7-8.4 parts of lactose monohydrate, 2.4 parts of hydroxypropyl cellulose L, 9.7-11.4 parts of D-glucosamine hydrochloride, 3 parts of carboxymethyl starch sodium and 0.7 part of magnesium stearate. The famciclovir tablet composition with stable performance provided by the invention solves the moisture absorption problem of thefamciclovir.

Description

technical field [0001] The invention relates to a composition of famciclovir tablets, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Famciclovir is a drug with high solubility and high permeability, which is mainly used clinically to treat herpes zoster and genital herpes. In the original prescription of famciclovir tablets, the amount of main drug of famciclovir accounted for more than 50% of the prescription, and the raw material of famciclovir was irregular crystals. During the process of wet granulation, it was found that the weight gain of famciclovir tablets exceeded the limit under high humidity environment, and the in vitro dissolution results of famciclovir tablets were not similar. [0003] At present, the anti-hygroscopic methods of hygroscopic drugs are: (1) Use suitable outer packaging, such as using aluminum-plastic coated bags, double aluminum coated bags or PVDC (polyvinylidene chloride) outer packaging, to blo...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K31/52A61P31/22
CPCA61K9/2054A61K9/2059A61K9/2018A61K31/52A61P31/22Y02A50/30
Inventor 王成张友凯王江涛杨德斌
Owner DISHA PHARMA GRP
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