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Magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance

An electron paramagnetic resonance and magnetic nanoparticle technology, which is applied in the directions of thermometers, thermometers, and heat measurement using electrical/magnetic components that are directly sensitive to heat, so as to achieve the effect of improving temperature measurement accuracy and broadening application scenarios.

Active Publication Date: 2021-03-23
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

However, limited by the strength of the proton resonance signal, although the internal temperature measurement of the living body can be realized, the temperature measurement accuracy can only reach 1°C

Method used

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  • Magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance
  • Magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance
  • Magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance

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[0051] 1. Simulation model and test instructions:

[0052] In order to study the feasibility of the magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance, the electronic paramagnetic resonance signal of magnetic nanoparticles is simulated. The simulation parameter is: the particle size D = 10 nm, the spin quantum number S = 5 / 2, the nuclear self-rotator number I = 1 / 2, the main magnetic field scan range is 145-445MT, the microwave frequency V = 9.141GHz, the simulation temperature 10 ° C.

[0053] 2. Simulation test results:

[0054] figure 2 Electronic paramagnetic resonance wave spectrum of magnetic nanoparticles having a particle diameter of 10 nm is reflected. It can be seen in the figure that the spectrum has only one large envelope peak, and the G factor is 2.2316.

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Abstract

The invention discloses a magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance, which belongs to the technical field of nano material testing. Electron paramagnetic resonance equipment is used for measuring the temperature by measuring the change of the g factor of the resonance spectrum of the magnetic nanoparticles; specifically, the magnetic nanoparticles have superparamagnetism, and the electron paramagnetic resonance spectrum shape of the magnetic nanoparticles is related to the particle size, temperature and concentration of the particles. Under the condition that the particle size of the particles is known, the central resonance magnetic field of the electron paramagnetic resonance spectrum, namely the change of the g factor is only related to the temperature and is not obviously related to the concentration. By means of the characteristic, the temperature in living organs, tissues and even cells can be rapidly and accurately detected, the magnetic nano temperature measurement application scene is greatly broadened, and compared with magnetic resonance temperature measurement, the temperature measurement precision is effectively improved.

Description

Technical field [0001] The present invention belongs to the field of nanomaterial testing, and more particularly to a magnetic nanoparticle temperature measurement method based on electronic paramagnetic resonance. Background technique [0002] Temperature is an important representation of life activities. In the field of life sciences, the temperature distribution of living cells is an important challenge for scientists. Perceived the "heat event" in the cell level helps to master the energy changes during the cell metabolism, which is of great significance for drug targeting, tumor thermal. However, due to the "closure" of the living, how non-invasive, accurate perceived measurement these "heat events" becomes the frontier topic and key challenges of life medicine. [0003] In recent years, the magnetic temperature measurement method has been considered to be one of the most prospects of the living temperature imaging in the field due to its good penetration. Magnetic nanoparti...

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Application Information

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IPC IPC(8): G01K7/36
CPCG01K7/36
Inventor 刘文中王帅杜中州
Owner HUAZHONG UNIV OF SCI & TECH
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