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A temperature measurement method for magnetic nanoparticles based on electron paramagnetic resonance

An electron paramagnetic resonance and magnetic nanoparticle technology, which is applied in the directions of thermometers, thermometers, and heat measurement using electrical/magnetic components that are directly sensitive to heat, to achieve the effect of broadening application scenarios and improving temperature measurement accuracy.

Active Publication Date: 2022-03-29
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

However, limited by the strength of the proton resonance signal, although the internal temperature measurement of the living body can be realized, the temperature measurement accuracy can only reach 1°C

Method used

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  • A temperature measurement method for magnetic nanoparticles based on electron paramagnetic resonance
  • A temperature measurement method for magnetic nanoparticles based on electron paramagnetic resonance
  • A temperature measurement method for magnetic nanoparticles based on electron paramagnetic resonance

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[0051] 1. Simulation model and test description:

[0052] In order to study the feasibility of the temperature measurement method of magnetic nanoparticles based on electron paramagnetic resonance, this example simulates the electron paramagnetic resonance signal of magnetic nanoparticles. The simulation parameters are: particle size D=10nm, spin quantum number S=5 / 2, nuclear spin quantum number I=1 / 2, main magnetic field scanning range is 145-445mT, microwave frequency v=9.141GHz, simulation temperature 10 ℃.

[0053] 2. Simulation test results:

[0054] figure 2 Reflects the electron paramagnetic resonance spectrum of magnetic nanoparticles with a particle size of 10 nm. It can be seen from the figure that the spectrum has only one large envelope peak with a g factor of 2.2316.

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Abstract

The invention discloses a method for measuring the temperature of magnetic nanoparticles based on electron paramagnetic resonance, and belongs to the technical field of nanometer material testing. The present invention uses electron paramagnetic resonance equipment to measure the temperature by measuring the change of the g factor of the magnetic nanoparticle resonance spectrum; specifically, the magnetic nanoparticle has superparamagnetism, and its electron paramagnetic resonance spectrum shape is related to particle size, temperature and concentration related. When the particle size is known, the central resonant magnetic field of electron paramagnetic resonance spectrum, that is, the change of g factor is only related to temperature, but has no obvious relationship with concentration. Using this feature can quickly and accurately detect the temperature inside living organs, tissues and even cells, which greatly broadens the application scenarios of magnetic nanothermometry, and compared with magnetic resonance thermometry, the temperature measurement accuracy has been effectively improved.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial testing, and more specifically relates to a method for measuring the temperature of magnetic nanoparticles based on electron paramagnetic resonance. Background technique [0002] Temperature is an important indicator of life activities. In the field of life sciences, imaging the temperature distribution of living cells is an important challenge for scientists. Sensing "thermal events" at the cellular level helps to grasp the energy changes in the process of cell metabolism, which is of great significance for drug targeting and tumor hyperthermia. However, due to the "closed nature" of living organisms, how to sense and measure these "thermal events" non-invasively and accurately has become a frontier topic and a key challenge in life medicine. [0003] In recent years, the magnetic temperature measurement method has been considered as one of the most promising methods in the field of in viv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01K7/36
CPCG01K7/36
Inventor 刘文中王帅杜中州
Owner HUAZHONG UNIV OF SCI & TECH
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