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EDTMP-modified ferroferric oxide nanoparticles and preparation method and application thereof

A technology of ferroferric oxide and nanoparticles, applied in nanotechnology, nanomedicine, nanotechnology, etc., can solve the problems of T1 signal decline, interference with relaxation process, high reaction temperature, etc., and achieve easy modification, good chemical stability, The effect of uniform particle size distribution

Active Publication Date: 2021-03-19
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Problems solved by technology

However, these systems still have certain limitations. For example, for developers with a core-shell structure, due to the strong magnetic coupling and high magnetic susceptibility effects of T2 materials, the magnetic field generated by superparamagnetic nanoparticles interferes with the external alignment of iron oxide nanoparticles. The relaxation process of magnetic substances, resulting in a decrease in T1 signal
GdIO is mostly synthesized by thermal decomposition method, the reaction temperature is high, and ligand exchange is required to improve its hydrophilicity, and the process is cumbersome.

Method used

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  • EDTMP-modified ferroferric oxide nanoparticles and preparation method and application thereof
  • EDTMP-modified ferroferric oxide nanoparticles and preparation method and application thereof
  • EDTMP-modified ferroferric oxide nanoparticles and preparation method and application thereof

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preparation example Construction

[0037] The invention provides a method for preparing ferric oxide nanoparticles modified by EDTMP, comprising:

[0038] FeCl 3 ·6H 2 O and FeCl 2 4H 2 O is mixed and dissolved in hydrochloric acid solution to obtain a mixed solution;

[0039] Mixing the mixed solution and the aqueous solution to react to obtain a reaction solution;

[0040] The reaction solution is reacted with the EDTMP solution to obtain ferric oxide nanoparticles modified by EDTMP.

[0041] In the present invention, the FeCl 3 ·6H 2 O and FeCl 2 4H 2 The ratio of the amount of O is preferably such that Fe 3+ with Fe 2+ The molar ratio is 1:(0.4-0.8), more preferably 1:(0.5-0.7), most preferably 1:0.6.

[0042]In the present invention, the hydrochloric acid solution is preferably an aqueous hydrochloric acid solution, and the concentration of the hydrochloric acid solution is preferably 0.5-1.5 mol / L, more preferably 1 mol / L. The present invention has no special limitation on the dosage of the hy...

Embodiment 1

[0064] Firstly, 50 mL of water was added to the three-necked flask, filled with nitrogen for 30 min to remove oxygen in the water, and the aqueous solution was heated to 80°C.

[0065] FeCl 3 ·6H 2 O and FeCl 2 4H 2 O Mole ratio (Fe 3+ : Fe 2+ =1:0.52) was dissolved in an appropriate amount of hydrochloric acid (1mol / L, 2mL); then, under nitrogen protection and mechanical stirring, the resulting mixed solution was quickly injected into the above aqueous solution, and then concentrated ammonia solution (mass concentration 25 %, 15mL) to adjust the pH to 9-10, react for 40min to obtain a reaction solution.

[0066] Adjust the pH of the reaction solution with hydrochloric acid to be 7, and an appropriate amount of EDTMP (Fe 3+ :EDTMP molar ratio of 1:0.3) was dissolved in dilute ammonia water (mass concentration 4%, 2.5mL), and the above reaction solution was added to continue the reaction for 30min.

[0067] After the reaction, it was naturally cooled to room temperature,...

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Abstract

The invention provides a preparation method of EDTMP-modified ferroferric oxide nanoparticles, and the preparation method comprises the following steps: mixing and dissolving FeCl3(subscript).6H2(subscript)O and FeCl2(subscript).4H2(subscript)O in a hydrochloric acid solution to obtain a mixed solution; mixing the mixed solution with an aqueous solution for reaction to obtain a reaction solution;and subjecting the reaction solution and an EDTMP solution to reaction to obtain the EDTMP-modified ferroferric oxide nanoparticles. The IO-EDTMP nanoparticles are synthesized by a modified coprecipitation method, so that the IO-EDTMP nanoparticles not only have good colloid stability and biocompatibility, but also have good T1 and T2 relaxation effects, and have potential application value in thefield of clinical MRI imaging diagnosis as a contrast agent. The invention also provides EDTMP-modified ferroferric oxide nanoparticles and application thereof.

Description

technical field [0001] The invention belongs to the technical field of imaging materials, and in particular relates to an EDTMP-modified iron ferric oxide nanoparticle and a preparation method and application thereof. Background technique [0002] In biomedical imaging technology, Magnetic Resonance Imaging (MRI) is often used to examine biological internal organs due to its advantages of no radiation damage, non-invasiveness, good deep tissue imaging and high spatial resolution. Rapid detection of soft tissue and soft tissue has become one of the most effective clinical diagnostic methods for diagnosing soft tissue lesions, especially tumor detection. MRI is the use of hydrogen nuclei in human tissue to be stimulated by radio frequency pulses in a magnetic field to generate nuclear magnetic resonance, generate magnetic resonance signals, and reconstruct tissue images of the human body in different physiological states. Moreover, MRI can also effectively change the spin rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10A61K49/18B82Y5/00
CPCA61K49/103A61K49/1842B82Y5/00
Inventor 章培标郝莉莉郭敏王宗良王宇
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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