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A hyaluronic acid-based wound hemostatic repair product and preparation method thereof

A technology of hyaluronic acid and products, which can be used in pharmaceutical formulations, bandages, drug delivery, etc. It can solve the problems of low bonding fastness, easy falling off and displacement, etc., and achieve excellent adhesion performance, difficult displacement, and improved strength.

Active Publication Date: 2022-05-27
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of low bonding fastness between the gel material and the base, easy falling off and displacement, etc., the present invention provides a hyaluronic acid-based wound hemostatic repair product, which improves the structure of the base and improves the coagulation rate. Bonding fastness between glue and substrate

Method used

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  • A hyaluronic acid-based wound hemostatic repair product and preparation method thereof
  • A hyaluronic acid-based wound hemostatic repair product and preparation method thereof
  • A hyaluronic acid-based wound hemostatic repair product and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Step 1: Prepare materials;

[0044] Step 2: take the substrate, soak it in ethanol for 20 minutes, ultrasonically clean it, then clean it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the middle, the reaction was carried out in a constant temperature water bath at 25°C for 24 hours, washed with deionized water, and dried to obtain a pretreated substrate with a polydopamine layer on the upper surface; the thickness of the polydopamine layer was 40 nm, and the substrate was non-woven fabric;

[0045] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and perform magnetron sputtering coating under the protection of argon gas, first coat a titanium layer on the surface of the polydopamine layer of the pretreated substrate, and then Coating a layer of silver on the surface of the titanium layer to obtain a modif...

Embodiment 2

[0051] Step 1: Prepare materials;

[0052] Step 2: take the substrate, soak it in ethanol for 25 minutes, ultrasonically clean it, then clean it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the middle, the reaction was performed in a constant temperature water bath at 27°C for 26 hours, washed with deionized water, and dried to obtain a pretreated substrate with a polydopamine layer on the upper surface; the substrate was a non-woven fabric, and the thickness of the polydopamine layer was 43 nm;

[0053] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and perform magnetron sputtering coating under the protection of argon gas, first coat a titanium layer on the surface of the polydopamine layer of the pretreated substrate, and then Coating a layer of silver on the surface of the titanium layer to obtain a modif...

Embodiment 3

[0059] Step 1: Prepare materials;

[0060] Step 2: take the substrate, soak it in ethanol for 30 minutes, ultrasonically clean it, then clean it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the middle, the reaction was performed in a constant temperature water bath at 28°C for 28 hours, washed with deionized water, and dried to obtain a pretreated substrate with a polydopamine layer on the upper surface; the substrate was a non-woven fabric, and the thickness of the polydopamine layer was 45 nm;

[0061] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and perform magnetron sputtering coating under the protection of argon gas, first coat a titanium layer on the surface of the polydopamine layer of the pretreated substrate, and then Coating a layer of silver on the surface of the titanium layer to obtain a modif...

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Abstract

The invention discloses a hyaluronic acid-based wound hemostatic repair product and a preparation method thereof, comprising a substrate and an active gel on the substrate, the substrate is a composite substrate, and the composite substrate from bottom to top is substrate, A polydopamine layer, a titanium layer and a silver layer, the composite substrate is provided with several grooves, the grooves are opened in the silver layer, and the depth reaches the polydopamine layer; the active gel is an active gel based on hyaluronic acid , the hyaluronic acid-based active gel is filled in the grooves and loaded on the entire upper surface of the composite substrate. The product of the present invention has excellent antibacterial properties, can promote wound repair, and inhibit wound bleeding. By improving the structure of the composite base layer, it can effectively fit the wound skin when used, and the wound dressing is not easy to deform, gel slipping, etc. High practicality.

Description

technical field [0001] The invention relates to a hyaluronic acid-based wound hemostasis repair product and a preparation method thereof, in particular to a hyaluronic acid-based wound hemostasis repair product with multiple functions such as hemostasis, repair, antibacterial and the like and a preparation method thereof, belonging to medical The technical field of gel products. Background technique [0002] Wound healing refers to a series of pathophysiological processes in which local tissue is repaired through regeneration, repair, and reconstruction after tissue loss due to the action of injury factors. In essence, it is an inherent defensive adaptive response of the body to tissue cell damage caused by various harmful factors; this regenerative repair is manifested in the recovery of lost tissue structure, and can also restore its function to varying degrees. [0003] Traditional wound repair materials such as gauze, animal fur, cotton, etc. are still used today becaus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/18A61L15/28A61L15/40A61L15/42
CPCA61L15/26A61L15/18A61L15/28A61L15/40A61L15/42A61L2300/104A61L2300/102A61L2300/30A61L2300/404A61L2300/412A61L2300/45A61L2400/04C08L79/02C08L5/08
Inventor 钱林艺郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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