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Lincomycin hydrochloride gel and preparation method thereof

A technology of lidocaine gel and lidocaine, which is applied in the field of lincomycin lidocaine gel and its preparation, can solve the problems of lincomycin content decrease, paste color deepening, poor stability, etc., and achieve Avoid product instability, low production cost, and good stability

Pending Publication Date: 2021-03-16
SHANGHAI NEW ASIATIC PHARMA MINHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to overcome the relatively poor stability of the lincomycin-lidocaine gel in the prior art, which tends to cause the content of lincomycin to decrease during storage, the color of the related substance lincomycin B and the paste to deepen, Blackening and other defects, and provide a kind of lincomycin lidocaine gel and preparation method thereof

Method used

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  • Lincomycin hydrochloride gel and preparation method thereof
  • Lincomycin hydrochloride gel and preparation method thereof
  • Lincomycin hydrochloride gel and preparation method thereof

Examples

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Effect test

Embodiment 1

[0050] Embodiment 1 lincomycin lidocaine gel

[0051] The raw material composition of the lincomycin-lidocaine gel of this embodiment is: in every 10g of lincomycin-lidocaine gel: the weight of lincomycin is 5 mg, lidocaine hydrochloride 4 mg, ethacridine lactate Pyridine is 0.2mg, carbomer 940 is 12mg, glycerin is 50mg, BHT is 0.5mg, triethanolamine is 12mg, brilliant blue is 0.02mg, 32218 water-soluble essence is 0.8mg, ethanol is 73mg, and the rest is purified water.

[0052]The preparation method of the lincomycin-lidocaine gel of this embodiment is as follows: Carbomer 940 and about 70% of purified water are stirred to swell completely to obtain a matrix; lincomycin hydrochloride solution is added to the matrix Then pump it into the stirring pot, pump glycerin, lidocaine hydrochloride solution, ethacridine lactic acid solution, BHT solution, 32218 water-soluble essence solution, ethanol, brilliant blue and the remaining water into the stirring pot respectively, and stir f...

Embodiment 2

[0053] Embodiment 2 lincomycin lidocaine gel

[0054] The raw material composition of the lincomycin lidocaine gel of this embodiment is: in every 10g of lincomycin lidocaine gel, the weight of lincomycin is 5 mg, lidocaine hydrochloride 4 mg, ethacridine lactate Pyridine is 0.2mg, carbomer 940 is 8mg, glycerin is 30mg, BHT is 1mg, triethanolamine is 8mg, brilliant blue is 0.01mg, 32218 water-soluble essence is 0.5mg, ethanol is 93mg, and the rest is purified water.

[0055] The preparation method of the lincomycin-lidocaine gel of this embodiment is as follows: Carbomer 940 and about 70% of purified water are stirred to swell completely to obtain a matrix; lincomycin hydrochloride solution is added to the matrix Then pump it into the stirring pot, pump glycerin, lidocaine hydrochloride solution, ethacridine lactic acid solution, BHT solution, 32218 water-soluble essence solution, ethanol, remaining water and brilliant blue into the stirring pot respectively, and stir for 10 ...

Embodiment 3

[0056] Embodiment 3 lincomycin lidocaine gel

[0057] The raw material composition of the lincomycin lidocaine gel of this embodiment is: in every 10g of lincomycin lidocaine gel, the weight of lincomycin is 5 mg, lidocaine hydrochloride 4 mg, ethacridine lactate Pyridine is 0.2mg, carbomer 940 is 20mg, glycerin is 80mg, potassium sorbate is 1mg, triethanolamine is 20mg, brilliant blue is 0.03mg, ethanol is 93mg, 32218 water-soluble essence is 2mg, and the rest is purified water.

[0058] The preparation method of the lincomycin-lidocaine gel of this embodiment is as follows: Carbomer 940 and about 70% of purified water are stirred to swell completely to obtain a matrix; lincomycin hydrochloride solution is added to the matrix Then pump it into the stirring pot, pump glycerin, lidocaine hydrochloride solution, ethacridine lactic acid solution, BHT solution, 32218 water-soluble essence solution, ethanol, remaining water and brilliant blue into the stirring pot respectively, and...

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Abstract

The invention discloses lincomycin hydrochloride gel. The lincomycin hydrochloride gel is characterized by being prepared from the following raw materials: lincomycin, a gel matrix, glycerol, lidocaine hydrochloride, ethacridine lactate, an antioxidant, essence, a coloring agent, a pH regulator, ethanol and water. The lincomycin hydrochloride gel is relatively good in stability, and meets the legal standards in the aspects of character, identification, loading, marking dosage, related substances, microbial limit and the like; under the normal storage condition, the validity period can reach 36months or above; and in the storage process, the content of the lincomycin is not obviously changed, the lincomycin B is not obviously increased, and the color of the paste is not changed.

Description

technical field [0001] The invention relates to a lincomycin lidocaine gel and a preparation method thereof. Background technique [0002] Lincomycin lidocaine gel is a green transparent water-based gel, which contains the antibiotic lincomycin (namely lincomycin) and the local anesthetic lidocaine, which is a commonly used external drug in dermatology. Lincomycin hydrochloride (lincomycin) contained in lincomycin lidocaine gel is an antibiotic, and its antibacterial spectrum is similar to that of erythromycin. It mainly has high antibacterial activity against Gram-positive bacteria, and its mechanism of action is to inhibit Bacterial protein synthesis. Lidocaine, as a local anesthetic, has analgesic and antipruritic effects for external use; lidocaine hydrochloride is a commonly used amide local anesthetic in clinical practice. Lincomycin lidocaine gel has the effect of relieving pain and itching. It is used for skin purulent inflammation, allergic inflammation, skin and ...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/167A61K9/06A61K47/18A61K47/14A61K47/12A61P29/00A61P17/00A61P37/08A61P17/04A61P17/02
CPCA61K9/06A61K31/167A61K31/7056A61K47/12A61K47/14A61K47/18A61P17/00A61P17/02A61P17/04A61P29/00A61P37/08A61K2300/00
Inventor 商鼎龚玉秀冯建新潘宏伟
Owner SHANGHAI NEW ASIATIC PHARMA MINHANG
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