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Application of sialic acid salt oil suspension in preparation of capsules

A sialic acid salt and sialic acid technology, applied in the application, capsule delivery, food forming and other directions, can solve the problems of affecting the appearance and shape of the capsule, the disintegration time limit of the dissolution rate, the product quality not meeting the requirements, and the small stimulation effect on the human body. , to avoid whitening appearance, easy storage, high sialic acid content

Active Publication Date: 2021-03-16
CABIO BIOTECH WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN111602821A discloses a microcapsule containing sialic acid and DHA and a preparation method thereof. The microcapsule containing sialic acid and DHA contains 15-25% of sialic acid, 15-25% of DHA, and 0.3-25% of Phytondo essential oil by mass percentage. 0.5%, calcium lactate 0.5-0.8%, emulsifier 1-2%, and composite wall material 46.7-68.2%, which have little stimulating effect on the human body, can be absorbed quickly, and have no residue, but it needs additional stabilizers to maintain the system Stablize
[0006] Previously, the applicant obtained a PUFA soft capsule containing sialic acid and its preparation method. The contents in the soft capsule include: PUFA oil suspension evenly dispersed sialic acid, with high content uniformity, high stability, portability and It can supplement a variety of nutrients at the same time, with little or no addition of antioxidants, high safety, and is suitable for pregnant and infant groups. However, the applicant found that in the longer-term stability evaluation, the sialic acid in the content will be mixed with the capsule capsule. The reaction of the gel components in the material will cause the capsule material to become hard, white, and spots appear on the inner layer, and the hardening of the capsule material will affect the appearance, shape, dissolution rate, and disintegration time limit of the capsule, thereby making the product quality up to less than required

Method used

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  • Application of sialic acid salt oil suspension in preparation of capsules
  • Application of sialic acid salt oil suspension in preparation of capsules
  • Application of sialic acid salt oil suspension in preparation of capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The present embodiment prepares sialate oil suspension, and described sialate oil suspension is sodium sialate 20% and docosahexaenoic acid grease (DHA grease) 80% by mass percentage, and its preparation method comprises the following steps :

[0088] (1) dissolving sialic acid in water, under high shear, adding sodium bicarbonate in molar mass ratio, reacting, forming sodium sialate solution, and adjusting the pH of sodium sialate solution to be 7;

[0089] (2) The sodium sialate solution is spray-dried under the conditions of an inlet air temperature of 210°C, a material temperature of 70°C, an outlet air temperature of 40°C, and a feed rate of 100L / h, followed by crushing to obtain the particle size Sodium sialate ≤100μm;

[0090] (3) Under 10000rpm shearing, sodium sialate is added to the DHA oil in proportion, sheared for 30min, and homogenized 3 times using a homogenizer (secondary pressure 8bar, primary pressure 1000bar) to obtain sialic acid Sodium Oil Suspens...

Embodiment 2

[0092] The present embodiment prepares sialate oil suspension, and described sialate oil suspension is sodium sialate 20%, phospholipid 0.5% and DHA grease 79.5% by mass percentage, and its preparation method comprises the steps:

[0093] (1) dissolving sialic acid in water, under high shear, adding sodium bicarbonate in molar mass ratio, reacting, forming sodium sialate solution, and adjusting the pH of sodium sialate solution to be 7;

[0094] (2) The sodium sialate solution is spray-dried under the conditions of an inlet air temperature of 210°C, a material temperature of 70°C, an outlet air temperature of 40°C, and a feed rate of 100L / h, followed by crushing to obtain the particle size Sodium sialate ≤100μm;

[0095] (3) Under 10000rpm shearing, sodium sialate and phospholipids are added in proportion to DHA oil, sheared for 30min, and homogenized 3 times using a homogenizer (secondary pressure 8bar, primary pressure 1000bar), to obtain Sodium sialate oil suspension.

Embodiment 3

[0097] The present embodiment prepares sialate oil suspension, and described sialate oil suspension is sodium sialate 40% and dihigh-γ-linolenic acid oil 60% by mass percentage, and its preparation method comprises the steps:

[0098] (1) dissolving sialic acid in water, under high shear, adding sodium bicarbonate in molar mass ratio, reacting, forming sodium sialate solution, and adjusting the pH of sodium sialate solution to be 7;

[0099] (2) The sodium sialate solution is spray-dried under the conditions of an inlet air temperature of 210°C, a material temperature of 70°C, an outlet air temperature of 40°C, and a feed rate of 100L / h, followed by crushing to obtain the particle size Sodium sialate ≤100μm;

[0100] (3) Under 8000rpm shearing, sodium sialate is added in proportion to two high-γ-linolenic acid oils, sheared for 35min, and homogenized 4 times using a homogenizer (secondary pressure 8bar, primary pressure 700bar), obtaining sodium sialate oil suspension.

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Abstract

The invention relates to an application of sialic acid salt oil suspension in preparation of capsules, the sialic acid salt oil suspension comprises sialic acid salt and grease, the sialic acid salt oil suspension has no negative influence on gel components in capsule wall materials, the problems that the appearance of the capsules becomes white, spots appear on the inner layer, and the capsules become hard are avoided, and the prepared capsules are easy to store and stable in quality; the sialic acid salt is good in dispersity in grease, a sialic acid salt oil suspension system bearing high-content sialic acid salt can still maintain good stability without additionally adding a stabilizer, and the content of the sialic acid salt oil suspension system can be kept uniform after the sialic acid salt oil suspension system is prepared into capsules. Capsules containing the sialic acid salt oil suspension are good in stability, high in sialic acid content and high in nutritional value, andhave wide application prospects in the field of nutritional supplements.

Description

technical field [0001] The invention belongs to the technical field of nutrition capsules, and relates to the application of sialate oil suspension in the preparation of capsules. Background technique [0002] Sialic acid, also known as N-acetylneuraminic acid, widely exists in animal tissues and microorganisms, and is usually located in the key position of the sugar part of the outermost layer of the cell membrane and the secreted sugar complex (glycolipid, glycoprotein and lipopolysaccharide) , is an important material basis for the diversification of the structure and function of carbohydrate complexes, and has physiological effects such as improving infant intelligence and memory, anti-senile dementia, anti-virus, and improving intestinal absorption of vitamins and minerals. With the further research and understanding of the biological activity of sialic acid, products produced from sialic acid have emerged, and the demand for sialic acid has also increased. [0003] Po...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23L29/00A23P10/30A23G3/36A23G3/40A61K31/7012A61K9/48A61K47/12A61P25/28A61P31/12A61P3/02
CPCA23L33/00A23L29/04A23P10/30A23G3/364A23G3/40A61K31/7012A61K9/4808A61K9/4858A61P25/28A61P31/12A61P3/02A23V2002/00A23V2200/30A23V2250/1868A23V2300/26A23V2250/1874A23V2250/18A23V2250/1862A23V2250/1882A23V2250/1876A23V2250/187
Inventor 汪志明李翔宇余道政肖敏陆姝欢
Owner CABIO BIOTECH WUHAN CO LTD
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