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A kind of nanofiber mask containing liposome and preparation method thereof

A nanofiber and nanofiber layer technology, applied in the field of cosmetic formulations, can solve problems such as failure to improve skin condition, loss of efficacy of active ingredients, blockage of sprayed fiber size, etc., to achieve good broad-spectrum antibacterial properties, maintain active efficacy, and good The effect of biocompatibility

Active Publication Date: 2021-12-10
JIANGSU JICUI ADVANCED POLYMER MATERIAL RES INST CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Sheet masks are usually made of non-woven fabrics. Although most non-woven fabrics can absorb essence and stick to the skin, there are still the following problems: (1) The diameter of non-woven fabric fibers is large, which is easy to rub against the skin, making it comfortable to use (2) There are few contact points with the skin per unit area, which is not conducive to the penetration of the essence into the skin
(3) Traditional facial mask essences need to add high doses of preservatives because they contain anti-oxidant active ingredients and a lot of water
However, there are still problems that the active ingredients need to be dispersed in the spinning stock solution, which is prone to aggregation, resulting in clogged spraying and uneven fiber size, and the active ingredients are easily oxidized and lose their efficacy during the preparation process, which cannot improve the skin condition. the role of

Method used

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  • A kind of nanofiber mask containing liposome and preparation method thereof
  • A kind of nanofiber mask containing liposome and preparation method thereof
  • A kind of nanofiber mask containing liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Add 0.2g chitosan to 100ml 1%wt aqueous acetic acid solution, stir and dissolve at 40°C. Adjust the pH value of the solution to 6.0 with 0.1M sodium hydroxide solution to obtain solution A.

[0039] 2) Mix solution A with 105mM potassium phosphate buffer solution at a ratio of 1:9 to obtain solution B.

[0040] 3) Add 2g of ferulic acid to 200ml of solution B, stir well to obtain solution C.

[0041] 4) Add 5 mg of horseradish peroxidase to solution C, add 0.5 ml of 10% volume fraction hydrogen peroxide solution every 3 minutes, stop the reaction after 90 minutes, and obtain solution D. The grafting reaction at room temperature was as figure 1 shown.

[0042] 5) Separate the solution D with a centrifuge at a speed of 5000r / min for 15 minutes, and the solution is separated into layers. The precipitated reaction product was collected, dissolved in 1% acetic acid solution with a certain mass fraction, and stored at room temperature until use.

[0043] 6) Dissolve s...

Embodiment 2

[0047] Except that in step 8, the concentration of the acetic acid solution of ferulic acid-grafted chitosan was adjusted to 0.2 mg / ml, the others were the same as in Example 1.

Embodiment 3

[0049] Except that in step 8, the concentration of the acetic acid solution of ferulic acid-grafted chitosan was adjusted to 0.3 mg / ml, the others were the same as in Example 1.

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Abstract

The invention relates to a liposome-containing nanofiber facial mask and a preparation method thereof, belonging to the field of cosmetic formulations. The invention adopts the nanofiber as the material of the facial mask, which improves the use comfort and the skin's absorption of the essence. The present invention uses ferulic acid-grafted chitosan to modify liposomes, combines with negatively charged liposomes through electrostatic interaction, forms a protective film on the liposome surface, and improves the stability and stability of the liposome system. Dimensional uniformity. The introduction of chitosan makes the liposome antibacterial. Ferulic acid can scavenge free radicals and has strong antioxidant activity, which plays a role in protecting the skin.

Description

technical field [0001] The invention relates to a liposome-containing nanofiber facial mask and a preparation method thereof, belonging to the field of cosmetic formulations. The invention adopts the nanofiber as the material of the facial mask, which improves the use comfort and the skin's absorption of the essence. In addition, liposomes encapsulating the active ingredients are added to the essence to slowly release the active ingredients to the skin. Background technique [0002] Along with the raising of my country's economic development and people's living standards, people pay more and more attention to skin care, especially the skin of the face. As one of the important cosmetics for facial skin care, facial mask has the characteristics of easy to carry, simple and effective operation, and is favored by consumers in general. Wet tissue sheet masks, which account for more than 80% of the mask market sales, are based on non-woven fabrics and absorb a certain amount of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/86A61K8/73A61K8/34A61K8/63A61K8/365A61K8/81A61K8/02A61K8/14A61Q19/00A61Q17/00
CPCA61K8/86A61K8/736A61K8/34A61K8/63A61K8/365A61K8/8129A61K8/0212A61K8/14A61Q19/00A61Q17/005
Inventor 刘颖王冀
Owner JIANGSU JICUI ADVANCED POLYMER MATERIAL RES INST CO LTD
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