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Mometasone furoate cream and preparation method thereof

A technology of mometasone furoate cream and mometasone furoate, applied in ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of high impurity content and low yield, and achieve high yield and high yield The effect of increasing the efficiency and reducing the impurity content

Inactive Publication Date: 2021-02-26
GUANGZHOU BAIYUNSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of mometasone furoate emulsifiable paste and preparation method thereof, to at least solve the problems of high impurity content and low yield in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The mometasone furoate cream of Example 1 of the present invention is made from the following weight ratio raw materials: 1 part of mometasone furoate, 100 parts of cetostearyl alcohol, 40 parts of light liquid paraffin, 80 parts of glycerin, single and double 100 parts of glyceryl stearate, 70 parts of 95% ethanol, 2 parts of titanium dioxide, 40 parts of polysorbate 80, 0.5 parts of ethylparaben, and 566.5 parts of purified water.

[0034] Specific preparation steps: Step 1, preparation of the oil phase: weigh cetostearyl alcohol, light liquid paraffin, glyceryl mono- and distearate by weight, place them in the oil phase heating tank, turn on the interlayer steam and heat to 85°C, Stir to dissolve and keep warm at 85°C for later use.

[0035] Step 2, preparation of the water phase: Weigh purified water, glycerin, and polysorbate 80 at least half of the prescription amount by weight, put them in the water phase heating tank, turn on the interlayer steam and heat to 85°...

Embodiment 2

[0042] The mometasone furoate cream of Example 2 of the present invention is made of the following raw materials by weight: 1 part of mometasone furoate, 100 parts of cetostearyl alcohol, 40 parts of light liquid paraffin, 80 parts of glycerin, 100 parts of glyceryl stearate, 70 parts of 95% ethanol, 2 parts of titanium dioxide, 40 parts of polysorbate 80, 0.5 part of ethylparaben, 0.27 part of phosphoric acid, 566.23 parts of purified water.

[0043] Step 1, the preparation of the oil phase: weigh cetostearyl alcohol, light liquid paraffin, glyceryl mono- and distearate by weight and place them in the oil phase heating tank, open the interlayer steam and heat to 85°C, stir and dissolve, 85 ℃ heat preservation standby;

[0044] Step 2, preparation of the water phase: Weigh purified water, glycerin, polysorbate 80 at least half of the prescription amount by weight, place in the water phase heating tank, turn on the interlayer steam and heat to 85°C, stir evenly, and keep warm a...

Embodiment 3

[0053] The mometasone furoate cream of Example 3 of the present invention is made from the following weight ratio raw materials: 1 part of mometasone furoate, 100 parts of stearyl alcohol, 40 parts of light liquid paraffin, 80 parts of glycerin, single and double stearic acid 100 parts of glyceryl acid, 70 parts of 95% ethanol, 2 parts of titanium dioxide, 40 parts of polysorbate 80, 0.5 parts of ethylparaben, and 566.5 parts of purified water.

[0054] Specific preparation steps: Step 1, preparation of the oil phase: weigh cetostearyl alcohol, light liquid paraffin, glyceryl mono- and distearate by weight, place them in the oil phase heating tank, turn on the interlayer steam and heat to 85°C, Stir to dissolve and keep warm at 85°C for later use.

[0055] Step 2, preparation of the water phase: Weigh purified water, glycerin, and polysorbate 80 at least half of the prescription amount by weight, put them in the water phase heating tank, turn on the interlayer steam and heat to ...

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Abstract

The invention relates to an external medicinal preparation, and particularly relates to an external medicine containing mometasone furoate and a preparation method thereof. In order to achieve the purpose, the invention provides mometasone furoate cream. The mometasone furoate cream is prepared from the following raw materials in parts by weight: 0.5 to 2 parts of mometasone furoate, 75 to 150 parts of an oil phase regulator, 30 to 50 parts of a consistency regulator, 60 to 100 parts of a humectant, 80 to 120 parts of a co-emulsifier, 60 to 90 parts of a co-solvent, 1 to 3 parts of a brightening agent, 30 to 50 parts of an emulsifier, 0.3 to 1 part of a preservative and 500 to 600 parts of water. The mometasone furoate cream prepared by the preparation method disclosed by the invention hasthe advantages of reduced impurity content, increased yield, advanced process, simple method and high yield.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for external use, in particular to a pharmaceutical preparation for external use containing mometasone furoate and a preparation method thereof. Background technique [0002] Mometasone furoate is a synthetic glucocorticoid drug. Mometasone furoate cream has the effect of relieving inflammation and itching. It is suitable for skin diseases that are effective for glucocorticoids. It has the characteristics of strong curative effect and low inhibition of adrenal cortex function. . However, the mometasone furoate emulsifiable paste prepared by the existing prescription and process has high impurity content, and the yield is low in the production process, resulting in great waste. Contents of the invention [0003] The purpose of the present invention is to provide a mometasone furoate cream and a preparation method thereof, so as to at least solve the problems of high impurity content and low yield ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/26A61K47/04A61K47/14A61K31/58A61P17/00A61P17/04A61P29/00
CPCA61K9/06A61K9/0014A61K47/10A61K47/26A61K47/02A61K47/14A61K31/58A61P17/00A61P17/04A61P29/00Y02A50/30
Inventor 朱岁华陈溪谢华金黄芷茵周洁高燕陈贤安唐九歌王智森
Owner GUANGZHOU BAIYUNSHAN PHARM CO LTD
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